Assistant Scientist I/II in Preclinical Development

Join Alumis Inc., a pioneering precision medicines company dedicated to transforming the lives of patients suffering from autoimmune diseases. Despite significant advancements in treatment over the past two decades, many individuals with immunologic conditions still struggle; our mission is to fundamentally improve their outcomes.The CMC team at Alumis is on…

Lead the analytical development and product characterization activities for our diverse drug development portfolios independently. Oversee, provide technical guidance, and direct analytical method development, transfer, validation, release, and stability testing activities at contract development and manufacturing organizations (CDMOs). Serve as a subject matter expert for comprehensive physical and chemical characterization of new chemical entities (NCEs) at contract research organizations (CROs).Independently design, conceptualize, and execute experiments while interpreting and presenting data and conclusions to a variety of audiences, including senior leadership. Tackle complex problems utilizing traditional and innovative analytical techniques. Ensure accurate and timely lab records in compliance with good documentation practices and all applicable laboratory, safety, quality, and regulatory standards.Develop and implement strategic project plans for internal and external projects, ensuring that product requirements are accurately designed and delivered on schedule for all stakeholders throughout the drug development continuum—from discovery through preclinical, clinical, and commercial stages. Provide technical support during investigations at CDMOs and CROs in collaboration with quality teams.Author and review technical reports, data packages, and relevant sections for health authority submissions including INDs, NDAs, and annual reports, while supporting due diligence and partnership efforts.Exhibit excellent communication skills in project management, including budget planning, overseeing progress and periodic accruals, and coordinating contracts, purchase orders, and invoices with finance; ensure follow-ups and maintain project timelines to meet high-quality deliverables.

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup dedicated to harnessing the power of artificial intelligence to revolutionize drug discovery and development. Our company is at the forefront of creating generative AI models that design innovative protein and antibody therapeutics, aiming to produce medicines that target historically challenging molecular entities. We are also advancing foundational models for biology and disease, which facilitate better target identification and patient stratification. Our technologies collectively strive to continually unveil novel therapies and enhance success rates in drug development. Headquartered in the vibrant San Francisco Bay Area, with additional offices in Seattle and London, Xaira is shaping the future of medicine.About the RoleWe are on the lookout for a passionate Scientist with robust hands-on molecular biology expertise and a creative, analytical, and innovative approach. This position emphasizes aiding in the design, construction, and refinement of cutting-edge screening platforms and experimental workflows that drive biological discoveries at scale.The ideal candidate is a proactive individual who thrives in uncertain problem spaces, meticulously considers experimental design, and takes initiative in transforming initial concepts into dependable, reproducible systems. You will engage collaboratively with various teams, including automation, engineering, and computation, to invent new methodologies for generating high-quality biological data.

Join Veracyte, where we are dedicated to revolutionizing cancer care for patients globally. Our team offers a dynamic workplace where you can make a significant difference in patients' lives while growing your skills in a mission-driven environment. This embodies the Veracyte way—collaborating with shared values to provide clinicians with critical insights that lead to impactful patient decisions.Our Core Values:We Seek A Better Way: We innovate courageously, learn from challenges, and remain resilient in transforming cancer care.We Make It Happen: We act swiftly, uphold quality, and incorporate enjoyment into our hard work.We Are Stronger Together: We foster open collaboration, strive for understanding, and celebrate our successes.We Care Deeply: We appreciate our differences, uphold integrity, and support one another.The Position:We are seeking a driven individual to join our Assay Development group as a Scientist I. This laboratory-based role will focus on assay development for high-throughput operations, significantly contributing to Veracyte’s innovative diagnostic products. You will play a key role in study design and documentation, executing bench studies while adhering to rigorous design control requirements.

Join AbbVie as a Senior Scientist I in our Quality Control team focused on Biologics Analytical Research & Development. In this pivotal role, you will leverage your expertise in analytical methods to ensure the quality and compliance of our biologic products. Collaborate with cross-functional teams to drive innovative solutions and contribute to the advancement of our research initiatives.

Join our dynamic team as an Analytical Scientist where you will play a pivotal role in driving scientific innovations. In this contract position, you will leverage your analytical expertise to conduct experiments, analyze data, and contribute to cutting-edge projects that impact our future.

Join our dynamic team as a Scientist I and contribute to groundbreaking research that drives innovation in the field. You will be an integral part of our scientific community, focusing on developing solutions that enhance our understanding of complex biological systems.

Position SummaryCellares is on the lookout for a dynamic and driven Senior Scientist with a strong background in cell therapy manufacturing to become a vital member of our Process Development team. This role offers a unique opportunity to collaborate with various departments and make substantial contributions to the advancement of our innovative cell therapy manufacturing platform.In this pivotal position, you will be responsible for designing, coordinating, executing, and analyzing experiments related to cell therapy process development. Your efforts will be instrumental in enhancing and optimizing the Cellares platform. The ideal candidate will exhibit exceptional organizational skills, demonstrate technical leadership, and possess a proven track record in developing robust autologous and allogeneic cell therapy processes.We seek individuals who thrive in a fast-paced, mission-driven environment and are eager to embrace a diverse range of challenges as Cellares continues to expand.

Join AbbVie as a Senior Scientist I in our Machine Learning team dedicated to advancing Biologics Drug Substance Development and Cell Culture Development. In this key role, you will leverage your expertise in machine learning to drive innovations that enhance our drug development processes.

Join Veracyte, a pioneering company in genomic diagnostics, as a Scientist I for a 9-month contract. In this role, you will contribute to groundbreaking research and development initiatives aimed at enhancing diagnostic accuracy and patient care. Collaborate with a dynamic team of scientists and professionals while leveraging cutting-edge technologies in a fast-paced environment.

At Veracyte, we are thrilled to invite talented individuals to join our innovative team dedicated to revolutionizing cancer care for patients worldwide. Being part of Veracyte empowers our employees to make a profound impact on patient lives while fostering personal and professional growth in a mission-driven environment. This embodies the Veracyte way: a collaborative approach guided by our core values, enabling clinicians with insights to help patients make transformative decisions.Our Values:We Seek A Better Way: We boldly innovate, learn from setbacks, and remain resilient in our mission to transform cancer care.We Make It Happen: We act swiftly, uphold quality, and infuse enjoyment into our hard work.We Are Stronger Together: We foster open collaboration, strive for understanding, and celebrate our achievements.We Care Deeply: We embrace diversity, act ethically, and support one another. The Position:We are seeking an enthusiastic and driven individual to become a vital member of our Product Development team as a Senior Scientist. This role is focused on the development of assays for high-throughput operations, contributing to Veracyte's groundbreaking diagnostic products. You will play a key role in study design and documentation, executing bench studies while adhering to rigorous design control standards.

About Us: Calico Life Sciences LLC, a cutting-edge research and development firm founded by Alphabet, is dedicated to unraveling the complexities of human aging through advanced technologies and innovative model systems. Our mission is to leverage this understanding to create interventions that promote longer, healthier lives. With state-of-the-art technology labs, a culture of curiosity-driven discovery, and a robust pipeline of drug development in collaboration with both academic and industry partners, Calico is an inspiring environment for catalyzing medical breakthroughs. Job Overview: We are on the lookout for a dynamic and passionate Scientist/Senior Scientist in Aging Biology to become a pivotal member of our Translational Medicine team. In this vital role, you will investigate the mechanisms of action (MOA) of therapeutic targets within our aging biology pipeline. The successful candidate will define the molecular and cellular pathways integral to our research programs, translating novel in vivo findings into a profound mechanistic understanding that will guide clinical development. The ideal candidate will possess substantial expertise in cell biology, MOA studies, and complex signaling pathways. Key Responsibilities: Design and implement experimental strategies to elucidate the molecular and cellular mechanisms of action for aging-related targets and biomarkers, providing insights that steer program direction. Execute in vitro and ex vivo studies to explore target biology in significant aging-related processes, such as stem cell function, tissue repair, and signaling or transcriptional regulation. Analyze acute and chronic pathway modulation in tissue injury and aging models to comprehend the evolution of stress responses and repair mechanisms in aging. Investigate the molecular drivers of in vivo phenotypes in preclinical aging models to identify biomarkers and translatable mechanisms for clinical development. Collaborate with in vivo pharmacology and biomarker teams to select optimal preclinical models that effectively probe target biology. Engage with cross-functional teams (e.g., Biomarkers, Genomics, Protein Sciences) to integrate multi-omic datasets and construct a comprehensive mechanistic framework. Analyze, interpret, and present complex data along with strategic recommendations to internal project teams and senior leadership. Maintain rigorous experimental documentation and contribute to internal reports, publications, and regulatory submissions.

At Alumis Inc., we are dedicated to revolutionizing the treatment landscape for patients suffering from autoimmune diseases. Our mission is to make a significant impact on the lives of those who have not benefited from recent medical advancements. We invite you to join us on this crucial journey.We are in search of a highly skilled and driven Senior Scientist to join our Drug Product Development team. This role will thrive in a collaborative and dynamic setting, focusing on critical activities in the development of our innovative molecules. Your key responsibilities will include creating pre-formulation packages, selecting formulations, and developing manufacturing processes. Initially, this role will prioritize solid oral dosage form development, with potential for involvement in other dosage forms as we expand.

Join Veracyte as a Senior Computational Development Scientist, where you will play a pivotal role in our mission to transform patient care through innovative genomics. In this remote position, you will leverage cutting-edge computational techniques to analyze complex genomic data, contributing to groundbreaking discoveries in cancer diagnostics.

About Us:Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development entity dedicated to advancing our understanding of human aging through cutting-edge technologies and model systems. Our mission is to leverage this knowledge to develop interventions that promote longer, healthier lives. At Calico, we foster a culture of curiosity-driven science, supported by a robust drug-development pipeline in collaboration with leading academic and industry partners, making us a dynamic environment for medical innovation.Position Overview:We are on the lookout for a seasoned Scientist to join our mass spectrometry proteomics team. The ideal candidate will exhibit enthusiasm, attention to detail, and exceptional organizational skills while tackling complex scientific challenges. This role focuses on employing chemoproteomics techniques via mass spectrometry to facilitate drug discovery, involving extensive sample handling and optimization of proteomics methodologies to propel our drug discovery initiatives forward.

Join Veracyte, a trailblazing organization dedicated to revolutionizing cancer care for patients worldwide. At Veracyte, our team members have the opportunity to make a significant difference in patients' lives while thriving in a mission-driven environment. We embrace the Veracyte way, which emphasizes collaboration, guided by our core values, to equip clinicians with the insights necessary for transformative patient care.Our Core Values:Innovative Mindset: We boldly pursue innovation, learn from challenges, and remain steadfast in our commitment to enhancing cancer care.Action-Oriented: We prioritize urgency, uphold quality standards, and infuse enjoyment into our dedicated efforts.Collaborative Spirit: We engage in open dialogue, strive for understanding, and celebrate our collective achievements.Deep Care: We honor our diversity, uphold ethical standards, and support each other.Position Overview:We are in search of an accomplished and passionate Bioinformatics Scientist to become a key member of our Bioinformatics and Data Science Team, focused on the creation of regulated diagnostic products. The ideal candidate will possess extensive knowledge of NGS technologies and a robust understanding of regulatory frameworks such as CAP/CLIA and IVD product development. This role is pivotal in the design, development, and optimization of our next generation of genomic assays. A unique combination of bioinformatics expertise, assay optimization experience, analytical validation skills, and a strong foundation in molecular biology is essential, along with a commitment to transforming complex biological data into actionable insights.

About Us: Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development firm with the mission to leverage cutting-edge technologies and experimental systems to deepen our understanding of the biology behind human aging. Our goal is to translate this knowledge into innovative interventions that enhance the quality and longevity of life. With a vibrant drug-development pipeline and a commitment to curiosity-driven scientific exploration, Calico offers a dynamic environment where medical breakthroughs are catalyzed and realized. Position Overview: We are on the lookout for a dedicated in vivo scientist to propel our neurodegenerative disease research forward, specifically targeting Parkinson's disease. This role is vital for designing, executing, and interpreting experiments utilizing rodent models to explore neurological and aging disorders while evaluating potential therapeutic interventions. The successful candidate will enhance our Translational Neuroscience team's capacity for in vivo research, establish sophisticated models for thorough investigation, and assess novel drug mechanisms of action. Additionally, the scientist will contribute to modeling innovative aspects of neurodegenerative diseases, integrate insights from human cohorts, and develop mechanistic models for hypothesis testing stemming from new target discoveries. Key Responsibilities: Develop and characterize novel in vivo models related to neurodegeneration and age-associated biology. Design and implement in vivo functional experiments for target validation and mechanistic biology studies. Conduct comprehensive animal behavioral assessments to delineate neurological phenotypes. Analyze, interpret, and effectively communicate data and results to the team. Maintain meticulous records of experiments, data, and findings in compliance with Calico guidelines. Participate in experimental design, data interpretation, and results presentation. Foster collaboration across multiple functional teams. Ensure adherence to all animal welfare regulations and institutional guidelines.

About Us: Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development entity dedicated to advancing our understanding of the biological mechanisms of human aging. Our mission is to leverage cutting-edge technologies and innovative model systems to create interventions that promote longer, healthier lives. With our state-of-the-art laboratories, commitment to curiosity-driven discovery, collaborative partnerships across academia and industry, and a dynamic drug development pipeline, Calico is an inspiring environment for driving impactful medical breakthroughs. Position Overview: The Cellular Models and Assay Technologies (CMAT) laboratory and the Microscopy group at Calico are in search of a highly skilled and driven bench Scientist to join our innovative teams. This position is at the forefront of spatial biology, concentrating on the intricate mapping of molecular environments involving proteins and protein complexes within both live and fixed cells and tissues. The ideal candidate will spearhead the creation and application of Laser Capture Microdissection (LCM) workflows integrated with various proximity biotinylation techniques to achieve exceptional resolution in multiomics experiments specific to cells and tissues. As a crucial member of our drug discovery and fundamental research initiatives, the successful applicant will play a significant role in identifying and validating novel therapeutic targets and biomarkers. This hands-on position necessitates a profound understanding of cell and tissue biology, biochemistry, microscopy, and image analysis, along with the capability to develop or adapt novel methodologies as required. We seek an independent, adaptable, and proactive scientist with outstanding communication skills who can effectively manage complex studies in a fast-paced environment.

Role overview insitro is hiring a Senior Machine Learning Scientist for its Computational Biology team in South San Francisco, CA. This group analyzes cellular aspects of in-vitro biology to support drug development. The work focuses on linking biological phenotypes to human diseases and translating those connections into insights for therapeutic discovery. What you will do Develop and improve machine learning methods for biological data analysis in areas such as network analysis, systems biology, graph-based modeling, causal structure learning, single cell omics, or imaging. Analyze high-throughput phenotypic screens and help create disease-relevant cell models. Work closely with experimental and computational biologists and other ML scientists to identify new phenotypes and design screening approaches. Integrate and interpret varied data types, including human cohort data, to uncover insights into disease mechanisms. Maintain high standards of scientific rigor and best practices in tool and analysis development. Report to the Head of Computational Biology and ML-Omics. Requirements Significant experience developing machine learning methods for biological data. Background in one or more of: network analysis, systems biology, graph-based modeling, causal structure learning, single cell omics, or imaging modalities. Strong analytical skills for complex, high-dimensional datasets. Ability to collaborate across scientific disciplines. Dedication to scientific rigor and high-quality research. Available to work on-site at least three days per week in South San Francisco. Why join insitro At insitro, team members work alongside talented colleagues in a biotech startup environment. The company values contributions that help shape both culture and strategic direction. This position offers the chance to expand skills and make a meaningful impact in drug discovery, with the potential to improve patient lives.