Bench Scientist - Entry Level Position

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup that harnesses the power of artificial intelligence to revolutionize drug discovery and development. Our mission is to develop cutting-edge generative AI models that design innovative protein and antibody therapeutics, paving the way for the creation of medicines targeting previously …

Join Xaira Therapeutics as a Senior Research Associate Scientist specializing in Display Technologies. In this pivotal role, you will be at the forefront of groundbreaking research and development initiatives that are shaping the future of therapeutic solutions. Your expertise will directly contribute to the innovation of our display technology, enhancing our product offerings and impacting the lives of patients worldwide.

About Xaira TherapeuticsXaira Therapeutics is a cutting-edge biotechnology startup that harnesses the power of artificial intelligence to revolutionize drug discovery and development. Our mission is to pioneer generative AI models that design innovative protein and antibody therapeutics, targeting previously challenging molecular entities. We are also creating foundational models to enhance biological and disease understanding, facilitating improved target identification and patient stratification. Our technologies aim to consistently identify breakthrough therapies and elevate success rates in drug development. Xaira is proudly headquartered in the San Francisco Bay Area, with additional locations in Seattle and London.About the RoleWe are seeking a passionate and detail-oriented protein biochemist who excels in hands-on laboratory execution. Your enthusiasm for display technology and drug discovery will drive you as you work towards developing transformative treatments for patients. You thrive in collaborative and fast-paced settings, continuously seeking to push the frontiers of scientific innovation.

Who We Are: Calico Life Sciences LLC is a pioneering research and development organization founded by Alphabet, dedicated to advancing the understanding of human aging through cutting-edge technologies and model systems. Our mission is to leverage this knowledge to develop interventions that promote longer, healthier lives. With a vibrant pipeline of drug development, innovative laboratory technologies, and a commitment to curiosity-driven discovery, Calico is a dynamic environment for driving impactful medical breakthroughs. Position Overview: We are on the lookout for a highly skilled and driven Principal Associate Scientist to lead our Biomarker Group in discovering and validating pharmacodynamic, prognostic, and predictive biomarker assays. This role supports a diverse array of clinical programs, including those focused on Neuroscience, Oncology, and aging-related diseases. The ideal candidate will possess over 15 years of experience in translational biology, molecular and cellular biology, and hands-on assay development, bridging the gap between early discovery and clinical development to ensure that our therapeutic candidates are underpinned by solid biomarker strategies. Key Responsibilities: Discovery & Validation: Lead the discovery and validation of pharmacodynamic biomarkers to support the clinical development of drugs with innovative mechanisms of action using preclinical models (both in vivo and in vitro) and human specimens. Assay Development: Spearhead the development, optimization, and qualification of biomarker assays across various platforms. Data Analysis & Interpretation: Conduct thorough analyses to establish pharmacokinetic/pharmacodynamic relationships and benchmark program compounds, utilizing statistical and specialized tools to interpret results from ex-vivo and in-vitro studies, delivering actionable insights for clinical dose selection, and synthesizing complex biological data into concise reports for senior management. Clinical Translation: Manage the technical transfer of validated assays to CROs or internal bioanalysis teams for Phase I/II studies. Strategic Intelligence: Gather and analyze competitive intelligence to guide discovery strategy and provide scenario assessments for high-priority clinical assets. Mentorship: Mentor and manage junior scientists, fostering a culture of technical excellence and scientific inquiry.

About Us:Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development entity dedicated to advancing our understanding of human aging through cutting-edge technologies and model systems. Our mission is to leverage this knowledge to develop interventions that promote longer, healthier lives. At Calico, we foster a culture of curiosity-driven science, supported by a robust drug-development pipeline in collaboration with leading academic and industry partners, making us a dynamic environment for medical innovation.Position Overview:We are on the lookout for a seasoned Scientist to join our mass spectrometry proteomics team. The ideal candidate will exhibit enthusiasm, attention to detail, and exceptional organizational skills while tackling complex scientific challenges. This role focuses on employing chemoproteomics techniques via mass spectrometry to facilitate drug discovery, involving extensive sample handling and optimization of proteomics methodologies to propel our drug discovery initiatives forward.

Join our dynamic team at Mindlance as an Associate Scientist. In this pivotal role, you will contribute to groundbreaking research initiatives and assist in the development of innovative solutions within the scientific community. Your expertise and analytical skills will help drive forward our mission to advance scientific knowledge and technology.

About Us: Calico Life Sciences LLC, a pioneering research and development company founded by Alphabet, is dedicated to exploring advanced technologies and biological systems that enhance our understanding of human aging. Our mission is to utilize this knowledge to develop interventions that promote longer, healthier lives. With cutting-edge technology labs and a vibrant pipeline of drug development in collaboration with esteemed academic and industry partners, Calico stands as an inspiring environment for catalyzing medical breakthroughs. Position Overview: We are on the lookout for a seasoned Process Chemist to become a vital member of our laboratory-based chemical development team. The ideal candidate will possess extensive hands-on experience in process research, route scouting, and the scale-up of organic molecules. In this role, you will be responsible for designing, optimizing, and executing synthetic processes that facilitate the efficient, safe, and scalable manufacturing of small-molecule intermediates and active pharmaceutical ingredients (APIs). This position is laboratory-focused and requires strong experimental skills, a profound understanding of organic chemistry, and the ability to convert laboratory discoveries into reliable processes. Key Responsibilities: Develop, optimize, and troubleshoot synthetic routes for intermediates and drug substance candidates. Conduct laboratory experiments aimed at enhancing yields, selectivity, throughput, and impurity management. Perform detailed reaction analysis utilizing HPLC, GC, LC-MS, and other analytical methodologies. Execute impurity identification and synthesis. Identify and mitigate process risks concerning safety, scalability, and robustness. Collaborate with cross-functional teams, including analytical chemistry, formulations, and quality assurance. Prepare concise, data-driven reports and present experimental findings to project teams. Facilitate technology transfer to contract manufacturing organizations, including review of master batch records and process descriptions. Maintain precise laboratory documentation and comply with all safety and regulatory standards.

About Us: Calico Life Sciences LLC, a pioneering research and development organization established by Alphabet, is dedicated to leveraging cutting-edge technologies and modeling systems to deepen our understanding of the biology underlying human aging. Our goal is to translate this knowledge into interventions that empower individuals to live longer, healthier lives. With a foundation in curiosity-driven scientific discovery and a robust drug-development pipeline in collaboration with academic and industry partners, Calico offers a dynamic environment for fostering innovative medical breakthroughs. Position Overview: We are on the lookout for a visionary Principal Scientist to connect computational design with experimental validation in our antibody discovery process. In this pivotal role, you will act as the key scientific liaison between our wet-lab antibody team and machine learning group, propelling the advancement of our "Design-Build-Test-Learn" framework. As both a project leader and technical authority, you will convert intricate in silico designs into practical experimental workflows. You will oversee the rigorous validation of computational predictions and ensure that the resulting biological data is organized to enhance and refine our internal models. We are seeking a seasoned expert in therapeutic antibody development who is eager to transcend traditional random screening methodologies and promote a rational, data-driven paradigm in biologic drug discovery.

insitro blends AI, large-scale biology, and drug discovery into a unified process. Predictive models guide laboratory experiments, while experimental results feed back to improve those models. This feedback loop aims to create a more efficient path from data to discovery. Role overview The Scientist I/II in Integrated Technology and Exploration designs and executes cell-based experiments, using both manual and automated workflows. The work focuses on generating key datasets that support and improve insitro’s predictive models. AI-generated predictions serve as hypotheses, which are tested at the bench. When results diverge from predictions, the scientist investigates whether the issue lies in the model, the experimental design, or the broader framework. Each experiment helps the system learn and become more accurate over time. What success looks like Consistent, high-quality execution of experiments that inform and refine predictive models Evidence-based contributions that improve the accuracy, calibration, and usefulness of the overall system Requirements Strong background in cell biology Comfort working at the intersection of experimental biology and computational modeling Curiosity and motivation to develop systems that improve through real-world data Work location and reporting This position is based onsite at insitro’s South San Francisco headquarters. Presence is required five days a week to maintain rapid feedback between experiments, automation, and AI analysis. The Scientist I/II reports to the Director of Integrated Technology Exploration.

Xaira Therapeutics is a biotech startup based in the San Francisco Bay Area, with additional offices in Seattle and London. The company applies artificial intelligence to drug discovery and development, building generative AI models to design protein and antibody therapeutics for challenging molecular targets. Xaira also develops foundational models in biology and disease to support target identification and patient stratification, aiming to improve outcomes in drug development. Role overview The High-Throughput team at Xaira is hiring an Associate Scientist to support the discovery and development of new protein therapeutics. This position focuses on designing and executing high-throughput expression, purification, and characterization campaigns. Collaboration is a key part of the role, with frequent interaction with robotics and data teams to combine biochemistry and automation. The goal is to turn computational protein designs into validated candidates for further study. What you will do Design and run high-throughput workflows for protein expression, purification, and characterization Work closely with robotics and data teams to integrate automation and data analysis Translate computational protein designs into physical candidates Help drive the discovery and development of next-generation protein therapeutics Who succeeds in this role Works well independently and as part of cross-functional teams Experience collaborating with discovery, process development, or analytical groups is helpful Communicates data clearly to different audiences Manages multiple tasks and adapts to shifting priorities Brings a hands-on approach and a drive to advance drug discovery through scientific innovation

Join Artech Information Systems LLC as an Associate Scientist II in Product Assurance, where you will play a pivotal role in ensuring the quality and reliability of our innovative products. You will collaborate with a dynamic team to perform testing and validation, contributing to the development of cutting-edge technologies.

Insitro, Inc. seeks an Associate Scientist III to join its team in South San Francisco. This position focuses on developing and refining methods to differentiate induced pluripotent stem cells (iPSCs) into mature cell types, particularly microglia and astrocytes, using samples from a range of patient donor lines. The work plays a key role in disease modeling and deepens the company’s insight into human biology. What you will do Adapt and optimize transcription factor-driven and directed differentiation protocols for iPSCs, with special attention to large-scale production. Develop and standardize quality control assays and cryopreservation strategies for progenitor cell banks. Execute co-culture and tri-culture in vitro models to study cellular interactions. Engineer iPSC lines by introducing transcription factor-expression cassettes using piggy-back transposon, viral transduction, and lipofectamine methods. Characterize in vitro models with flow cytometry, immunocytochemistry, and transcriptomics. Validate model functionality using live-cell assays. Scale and perform quality control assays for various mammalian cell types, using automated high-content microscopy. Work with cross-functional teams to bring automation solutions into cell biology workflows. Deliver high-quality iPSC-derived cellular data to support predictive machine learning model development. Share data and project updates in team and company-wide meetings. Location This role is based in South San Francisco, CA.

About Us: Calico Life Sciences LLC, a cutting-edge research and development firm founded by Alphabet, is dedicated to unraveling the complexities of human aging through advanced technologies and innovative model systems. Our mission is to leverage this understanding to create interventions that promote longer, healthier lives. With state-of-the-art technology labs, a culture of curiosity-driven discovery, and a robust pipeline of drug development in collaboration with both academic and industry partners, Calico is an inspiring environment for catalyzing medical breakthroughs. Job Overview: We are on the lookout for a dynamic and passionate Scientist/Senior Scientist in Aging Biology to become a pivotal member of our Translational Medicine team. In this vital role, you will investigate the mechanisms of action (MOA) of therapeutic targets within our aging biology pipeline. The successful candidate will define the molecular and cellular pathways integral to our research programs, translating novel in vivo findings into a profound mechanistic understanding that will guide clinical development. The ideal candidate will possess substantial expertise in cell biology, MOA studies, and complex signaling pathways. Key Responsibilities: Design and implement experimental strategies to elucidate the molecular and cellular mechanisms of action for aging-related targets and biomarkers, providing insights that steer program direction. Execute in vitro and ex vivo studies to explore target biology in significant aging-related processes, such as stem cell function, tissue repair, and signaling or transcriptional regulation. Analyze acute and chronic pathway modulation in tissue injury and aging models to comprehend the evolution of stress responses and repair mechanisms in aging. Investigate the molecular drivers of in vivo phenotypes in preclinical aging models to identify biomarkers and translatable mechanisms for clinical development. Collaborate with in vivo pharmacology and biomarker teams to select optimal preclinical models that effectively probe target biology. Engage with cross-functional teams (e.g., Biomarkers, Genomics, Protein Sciences) to integrate multi-omic datasets and construct a comprehensive mechanistic framework. Analyze, interpret, and present complex data along with strategic recommendations to internal project teams and senior leadership. Maintain rigorous experimental documentation and contribute to internal reports, publications, and regulatory submissions.

About Us: Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development entity dedicated to advancing our understanding of the biological mechanisms of human aging. Our mission is to leverage cutting-edge technologies and innovative model systems to create interventions that promote longer, healthier lives. With our state-of-the-art laboratories, commitment to curiosity-driven discovery, collaborative partnerships across academia and industry, and a dynamic drug development pipeline, Calico is an inspiring environment for driving impactful medical breakthroughs. Position Overview: The Cellular Models and Assay Technologies (CMAT) laboratory and the Microscopy group at Calico are in search of a highly skilled and driven bench Scientist to join our innovative teams. This position is at the forefront of spatial biology, concentrating on the intricate mapping of molecular environments involving proteins and protein complexes within both live and fixed cells and tissues. The ideal candidate will spearhead the creation and application of Laser Capture Microdissection (LCM) workflows integrated with various proximity biotinylation techniques to achieve exceptional resolution in multiomics experiments specific to cells and tissues. As a crucial member of our drug discovery and fundamental research initiatives, the successful applicant will play a significant role in identifying and validating novel therapeutic targets and biomarkers. This hands-on position necessitates a profound understanding of cell and tissue biology, biochemistry, microscopy, and image analysis, along with the capability to develop or adapt novel methodologies as required. We seek an independent, adaptable, and proactive scientist with outstanding communication skills who can effectively manage complex studies in a fast-paced environment.

Join our dynamic team as an Analytical Scientist where you will play a pivotal role in driving scientific innovations. In this contract position, you will leverage your analytical expertise to conduct experiments, analyze data, and contribute to cutting-edge projects that impact our future.

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup dedicated to revolutionizing drug discovery and development through the power of artificial intelligence (AI). Our mission is to lead the advancement of generative AI models designed specifically for creating innovative protein and antibody therapeutics. This allows us to tackle previously challenging molecular targets and develop effective medicines. We are also at the forefront of developing foundational models for biology and disease, facilitating improved target identification and patient stratification. Through our cutting-edge technologies, we aim to consistently discover novel therapies and enhance the success rates of drug development. Xaira has its headquarters in the vibrant San Francisco Bay Area, Seattle, and London.Position OverviewWe are on the lookout for dynamic and passionate candidates to join our innovative team as an AI Scientist! In this role, you will leverage your experience in developing and implementing advanced deep learning methodologies, showcasing a proven record of AI innovation through publications in the fields of Artificial Intelligence or Machine Learning, or through significant interdisciplinary projects. As a vital member of our core AI team, composed of exceptionally talented and creative individuals, you will spearhead exciting projects aimed at advancing state-of-the-art AI models in biology that influence drug discovery and clinical development. This role also provides the opportunity to collaborate with interdisciplinary experts in world-class biology, drug discovery, and clinical domains. Xaira values diversity and encourages candidates from all backgrounds and experiences to apply, as we believe that teams thrive when varied perspectives are included.The position is available in the following locations: San Francisco Bay Area, Seattle, and London.

About Us: Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development firm with the mission to leverage cutting-edge technologies and experimental systems to deepen our understanding of the biology behind human aging. Our goal is to translate this knowledge into innovative interventions that enhance the quality and longevity of life. With a vibrant drug-development pipeline and a commitment to curiosity-driven scientific exploration, Calico offers a dynamic environment where medical breakthroughs are catalyzed and realized. Position Overview: We are on the lookout for a dedicated in vivo scientist to propel our neurodegenerative disease research forward, specifically targeting Parkinson's disease. This role is vital for designing, executing, and interpreting experiments utilizing rodent models to explore neurological and aging disorders while evaluating potential therapeutic interventions. The successful candidate will enhance our Translational Neuroscience team's capacity for in vivo research, establish sophisticated models for thorough investigation, and assess novel drug mechanisms of action. Additionally, the scientist will contribute to modeling innovative aspects of neurodegenerative diseases, integrate insights from human cohorts, and develop mechanistic models for hypothesis testing stemming from new target discoveries. Key Responsibilities: Develop and characterize novel in vivo models related to neurodegeneration and age-associated biology. Design and implement in vivo functional experiments for target validation and mechanistic biology studies. Conduct comprehensive animal behavioral assessments to delineate neurological phenotypes. Analyze, interpret, and effectively communicate data and results to the team. Maintain meticulous records of experiments, data, and findings in compliance with Calico guidelines. Participate in experimental design, data interpretation, and results presentation. Foster collaboration across multiple functional teams. Ensure adherence to all animal welfare regulations and institutional guidelines.

Join our dynamic team as a Scientist I and contribute to groundbreaking research that drives innovation in the field. You will be an integral part of our scientific community, focusing on developing solutions that enhance our understanding of complex biological systems.

Join Veracyte, a trailblazing organization dedicated to revolutionizing cancer care for patients worldwide. At Veracyte, our team members have the opportunity to make a significant difference in patients' lives while thriving in a mission-driven environment. We embrace the Veracyte way, which emphasizes collaboration, guided by our core values, to equip clinicians with the insights necessary for transformative patient care.Our Core Values:Innovative Mindset: We boldly pursue innovation, learn from challenges, and remain steadfast in our commitment to enhancing cancer care.Action-Oriented: We prioritize urgency, uphold quality standards, and infuse enjoyment into our dedicated efforts.Collaborative Spirit: We engage in open dialogue, strive for understanding, and celebrate our collective achievements.Deep Care: We honor our diversity, uphold ethical standards, and support each other.Position Overview:We are in search of an accomplished and passionate Bioinformatics Scientist to become a key member of our Bioinformatics and Data Science Team, focused on the creation of regulated diagnostic products. The ideal candidate will possess extensive knowledge of NGS technologies and a robust understanding of regulatory frameworks such as CAP/CLIA and IVD product development. This role is pivotal in the design, development, and optimization of our next generation of genomic assays. A unique combination of bioinformatics expertise, assay optimization experience, analytical validation skills, and a strong foundation in molecular biology is essential, along with a commitment to transforming complex biological data into actionable insights.