Commissary Director

Join AbbVie as the Director of AI Transformation, where you will lead the charge in harnessing artificial intelligence to drive innovation and improve patient outcomes. You will be responsible for developing and implementing cutting-edge AI strategies that align with our mission to enhance the quality of life for patients around the globe. Collaborate with c…

Join AbbVie as an Associate Director of AI Transformation, where you will play a pivotal role in driving our AI initiatives to enhance patient outcomes and operational efficiency. This leadership position requires a blend of strategic vision and technical expertise, ensuring our AI solutions align with our organizational goals.In this role, you will lead a cross-functional team, collaborate with stakeholders, and leverage cutting-edge AI technologies. Your contributions will directly impact our commitment to innovation and excellence in healthcare.

As the Director of Discovery AI Partnerships at AbbVie, you will be at the forefront of innovative collaborations that leverage artificial intelligence to enhance our drug discovery processes. You will lead strategic initiatives, build and maintain relationships with key partners, and drive the integration of AI technologies into our research frameworks. This leadership role requires a visionary mindset, strong project management skills, and the ability to navigate complex scientific challenges.

We are seeking a dynamic and experienced Director of Global Alliances - AI to lead our strategic partnerships and collaborations in the artificial intelligence domain. This pivotal role will involve driving the development and execution of joint initiatives with industry leaders and technology partners. You will be responsible for identifying new partnership opportunities, negotiating agreements, and ensuring alignment with AbbVie’s strategic goals.As a key member of our leadership team, you will work closely with cross-functional teams to enhance our AI capabilities and deliver innovative solutions that can transform patient care. Your expertise in AI technologies and market trends will be essential in shaping our partnerships and ensuring their success.

About Us Kardigan is a pioneering heart health company dedicated to transforming cardiovascular disease into conditions that are preventable and curable, ultimately eliminating it as the leading cause of death globally.Our mission at Kardigan is to create multiple targeted treatments simultaneously, ensuring that individuals with cardiovascular diseases receive the cures they rightfully deserve. Under the leadership of accomplished co-founders Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan has developed a cutting-edge discovery and translational research platform, supported by a pipeline of late-stage candidates and an industry-leading team devoted to enhancing patient outcomes. At Kardigan, our core values shape how we operate, collaborate, and achieve our objectives. We are driven by patients and their families, passionately prioritizing their needs. We value authenticity, leading with honesty to nurture a culture of acceptance and support. Our team embodies an eagerness to learn, fostering curiosity and adaptability. We are committed to winning as a team with a focus on urgency, excellence, and intention, supporting one another regardless of roles. Finally, we aim to enable the impossible, unafraid to take risks to foster innovation and propel scientific advancements. These guiding principles empower us to effect meaningful change every day.  

Join AbbVie as the Director of Discovery AI Partnerships, where you will spearhead innovative collaborations aimed at harnessing artificial intelligence to transform the landscape of healthcare. In this pivotal role, you will be at the forefront of developing strategic partnerships with external research organizations and technology firms. Your expertise in AI integration will be crucial in advancing our mission to improve patient outcomes.

About Xaira TherapeuticsXaira Therapeutics is a cutting-edge biotechnology startup dedicated to harnessing the power of artificial intelligence to revolutionize the fields of drug discovery and development. Our mission is to innovate generative AI models that facilitate the design of protein and antibody therapeutics, paving the way for effective treatments against traditionally challenging molecular targets. In addition, we are advancing foundational biological models to enhance target identification and patient stratification. These pioneering technologies are designed to continuously uncover novel therapies and boost the success rates in drug development. Our headquarters are strategically located in the San Francisco Bay Area, Seattle, and London.About the RoleWe are seeking an AI Scientist to become an integral part of our team at the convergence of machine learning and single-cell biology. In this pivotal role, you will focus on the development and application of foundational models to large-scale perturb-seq and single-cell datasets, revealing new biological mechanisms and therapeutic potentials. You will be responsible for designing scalable machine learning architectures that can extract insights from high-dimensional perturbation data and integrate across multi-omic modalities.

The OpportunityThe remarkable integration of multi-modal data, advanced disease modeling, and cutting-edge computational capabilities is transforming the landscape of drug discovery. At insitro, we are seizing this pivotal moment to revolutionize the development of treatments for complex diseases. Our AI and machine learning-driven platforms are designed to integrate and scale data swiftly, enabling the discovery of novel biological insights that redefine complex diseases and pinpoint new therapeutic targets and drugs.To realize this ambitious vision, we are in search of a Senior Director of Project & Portfolio Management (PPM) who will spearhead the creation of an AI-centric PPM organization. This role will collaborate closely with Therapeutic Area, Operations, Clinical, and Business Development teams to advance a high-impact portfolio of innovative drug candidates targeting neurological, ophthalmological, and metabolic conditions.Reporting to the Chief Scientific Officer, you will work alongside project team leaders to formulate tailored project strategies and cultivate a high-performance team environment that promotes rapid advancement. You will be responsible for developing and executing comprehensive integrated project plans with clearly defined timelines across research, discovery, clinical development, software engineering, and data science/machine learning. As the head of PPM, you will also collaborate with colleagues in Compute, Operations, and Finance to establish sophisticated AI-driven project management, decision-making, and resource allocation methodologies to support critical initiatives.This position is hybrid, requiring three days per week on-site at our South San Francisco headquarters.

Role overview Calico Labs is hiring a Director or Associate Director of Toxicology to lead research into the safety profiles of compounds under development. This leadership role shapes the approach to evaluating toxicological effects and plays a key part in decisions that guide the direction of health research at Calico Labs. Key responsibilities Direct research initiatives to assess the toxicological impacts of compounds in the development pipeline Guide safety and efficacy evaluations at each stage of the development process Work closely with scientific teams to inform study design and interpret results Apply toxicology expertise to advance Calico Labs' mission in health innovation Location This position is based in South San Francisco, CA.

Xaira Therapeutics develops protein and antibody therapeutics using generative AI models, with the goal of targeting difficult molecular challenges in drug discovery. The company’s foundation models support better identification of drug targets and patient groups, aiming to improve the success rate of new therapies. Xaira is headquartered in the San Francisco Bay Area, with offices in Seattle and London. Role overview The Senior Director of Supply Chain and Strategic Sourcing leads supply chain, procurement, and contract governance across Xaira. This position is responsible for ensuring reliable access to external partners, platforms, and services that support teams in Research, Biomedical AI, Platform Engineering, and Corporate operations. What you will do Build and implement a sourcing strategy that supports Xaira’s mission and growth plans Strengthen vendor management and relationships with key suppliers and service providers Develop and oversee a contract governance framework Maintain operational continuity with external partners Transform procurement and contracts into a unified, scalable supply chain function Focus areas This leadership role sits at the intersection of research, technology infrastructure, and external partnerships. The Senior Director will align sourcing, vendor, and contract decisions with Xaira’s long-term goals.

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup dedicated to harnessing the power of artificial intelligence to revolutionize drug discovery and development. Our mission is to advance the frontier of generative AI models which design innovative protein and antibody therapeutics, making strides against previously difficult molecular targets. Additionally, we are committed to creating foundational models for biology and disease, enhancing target identification and patient stratification. Through these cutting-edge technologies, we aim to consistently unveil novel therapies and elevate the success rates in drug development. Headquartered in the dynamic San Francisco Bay Area, with additional offices in Seattle and London, we are at the forefront of biotech innovation.AI in ResidenceThe AI in Residence program is a highly selective opportunity designed for those at the forefront of machine learning and drug discovery. This role serves as an industry alternative to a traditional postdoctoral position, tailored for exceptional researchers and engineers eager to apply advanced AI methodologies to real-world biomedical challenges, encompassing the entire process from data handling to system deployment.As a resident, you will join a small, focused cohort engaged in high-impact AI projects throughout Xaira. You will closely collaborate with AI scientists, research engineers, and drug discovery teams to conceptualize, develop, and deliver machine learning capabilities that directly impact therapeutic programs. This role demands hands-on, system-level work with tangible scientific implications.We seek candidates who possess technical expertise, intellectual independence, robust research judgment, and a proven track record of high-quality deliverables, whether through publications, contributions to open-source projects, or production systems.

Join AbbVie as a Scientific Director / Medical Director in the field of Medical Affairs focusing on Oncology, specifically targeting Ovarian Solid Tumor. In this pivotal role, you will lead strategic initiatives and research efforts aimed at improving patient outcomes through innovative therapies. Collaborate with cross-functional teams to develop and implement comprehensive medical strategies that align with our commitment to advancing oncology care.

The PositionAs the Director of Biostatistics at Maze Therapeutics, you will be pivotal in guiding the clinical advancement of our innovative therapeutic programs. This role involves close collaboration with teams in Clinical Science, Regulatory Affairs, Clinical Pharmacology, Development Science, and Translational Science, ensuring our clinical studies are methodologically sound, data-driven, and impactful.You will be responsible for the biostatistical strategy and execution, overseeing the entire process from study design to regulatory submissions, seamlessly blending hands-on expertise with strategic oversight. Your role will include representing the Biostatistics function in clinical study teams, guiding the interpretation of intricate data, and managing CRO partnerships to guarantee the delivery of high-quality statistical outputs.This position reports directly to the Vice President of Biometrics.Your ImpactLead biostatistical efforts for clinical studies, offering expert insights on study design, endpoints, and statistical methodologies.Oversee the completion of all technical and operational statistical tasks for a portfolio of clinical trials, ensuring the development and review of complex and innovative statistical analysis plans (SAPs).Work collaboratively with cross-functional teams on protocol development, study design discussions, and data interpretation.Partner with Statistical Programming to develop and validate analyses for internal purposes, publications, and regulatory submissions.Supervise CRO execution of statistical tasks, ensuring adherence to timelines, quality standards, and analytical approaches.Represent the Biostatistics department in regulatory interactions (FDA, EMA, PMDA, etc.), contributing to briefing documents, meeting preparations, and responses to agency inquiries.Contribute to clinical study reports (CSRs), integrated summaries (ISS/ISE), and regulatory submissions (NDA/BLA/MAA).Utilize advanced statistical techniques to analyze and interpret clinical, safety, biomarker, and exploratory data.Advise internal and external stakeholders on statistical methodologies, data integrity, model selection, and result interpretation.Lead the integration and analysis of diverse data sources to facilitate the delivery of special projects and statistical analysis plans for assigned products.Review and assess safety reports, biomarker analyses, and other elements of clinical trial monitoring.Enhance statistical software as needed by programming new techniques; stay updated on current and emerging trends in statistical analysis methodologies and tools.Provide biostatistical input into clinical development documentation and scientific publications.

About the RoleAs the Director of Statistics at AbbVie, you will lead a talented team of statisticians in designing and analyzing clinical trials, ensuring the highest standards of statistical rigor. You will collaborate with cross-functional teams to drive innovative solutions that impact patient outcomes.Key ResponsibilitiesOversee statistical methodology development and implementation for clinical research.Guide statistical analysis plans and ensure compliance with regulatory standards.Mentor and develop junior statisticians and promote a collaborative environment.

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup dedicated to revolutionizing drug discovery and development through the power of artificial intelligence (AI). Our mission is to lead the advancement of generative AI models designed specifically for creating innovative protein and antibody therapeutics. This allows us to tackle previously challenging molecular targets and develop effective medicines. We are also at the forefront of developing foundational models for biology and disease, facilitating improved target identification and patient stratification. Through our cutting-edge technologies, we aim to consistently discover novel therapies and enhance the success rates of drug development. Xaira has its headquarters in the vibrant San Francisco Bay Area, Seattle, and London.Position OverviewWe are on the lookout for dynamic and passionate candidates to join our innovative team as an AI Scientist! In this role, you will leverage your experience in developing and implementing advanced deep learning methodologies, showcasing a proven record of AI innovation through publications in the fields of Artificial Intelligence or Machine Learning, or through significant interdisciplinary projects. As a vital member of our core AI team, composed of exceptionally talented and creative individuals, you will spearhead exciting projects aimed at advancing state-of-the-art AI models in biology that influence drug discovery and clinical development. This role also provides the opportunity to collaborate with interdisciplinary experts in world-class biology, drug discovery, and clinical domains. Xaira values diversity and encourages candidates from all backgrounds and experiences to apply, as we believe that teams thrive when varied perspectives are included.The position is available in the following locations: San Francisco Bay Area, Seattle, and London.

Join AbbVie as an Associate Director of Innovation, where you will play a crucial role in driving the future of our research and development initiatives. This dynamic position allows you to collaborate with cross-functional teams to identify and implement innovative solutions that enhance our product offerings.

Calico Labs seeks an Associate Director or Director of In Vivo Physiology to join its team in South San Francisco, CA. This leadership role centers on research aimed at understanding and addressing diseases linked to aging. Role overview The Associate Director or Director will shape the scientific direction for in vivo physiology studies. This position supports Calico’s mission to advance health through research focused on age-related conditions. Key responsibilities Guide research projects that investigate the biology of aging and related diseases Direct scientific strategy and help set priorities for the in vivo physiology group Support Calico’s broader goals by fostering collaboration and scientific excellence Location This position is based in South San Francisco, CA.

Cellares is on the lookout for a visionary and dynamic Director of Facilities Engineering to play a pivotal role in driving our mission to enhance access to transformative cell therapies.In this critical position, you will oversee the management, operations, and maintenance of our facilities and crucial support systems, ensuring adherence to GMP, quality, and Environmental Health and Safety (EHS) standards. Your responsibilities will include managing office spaces, cGMP cleanroom suites, QC laboratories, warehouses, utility systems (gases, HVAC, lab equipment), and all equipment integral to our cell therapy operations. Additionally, you will lead our maintenance and calibration programs, cleaning initiatives, and capital expansion projects (CAPEX), which involve facility buildouts.The ideal candidate will have a robust background in facilities leadership, particularly within cGMP operations in the biotech or pharmaceutical sectors. You will be instrumental in providing strategic vision and leadership to ensure the reliability of our facilities, compliance with state and federal regulations, and the continuous improvement of processes that propel our business growth.This position is multidisciplinary, requiring collaboration across various departments, including scientists, researchers, and engineers, to devise optimal solutions. We are looking for a proactive and self-sufficient individual who thrives in a fast-paced, mission-driven environment and is ready to embrace a diverse range of challenges as our company expands.

About Us Kardigan is a pioneering heart health company dedicated to transforming cardiovascular disease into a preventable, treatable condition, aiming to eliminate it as the leading cause of death globally.Our mission is to develop a diverse range of targeted treatments concurrently that will lead to the cures our patients with cardiovascular diseases deserve. Founded by industry leaders Tassos Giannakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s founders have reunited following their success at MyoKardia, where they facilitated the discovery and development of mavacamten, the first cardiac myosin inhibitor, culminating in the acquisition by Bristol Myers Squibb in 2020. We boast a cutting-edge discovery and translational research platform, a pipeline full of late-stage candidates, and an exceptional team devoted to enhancing patient lives. At Kardigan, our values drive our work, interactions, and achievements. We are patient-centered, fiercely committed to improving lives and prioritizing patient needs. We believe in authenticity, fostering an environment of acceptance through honest leadership. With a curiosity-driven mindset, we encourage innovative thinking and adaptability. We strive for team success, supporting one another in our collective mission with urgency and excellence. Finally, we aim to enable the impossible, taking calculated risks to inspire innovation and advance scientific breakthroughs. Our core values empower us daily to make a significant impact. Position Title: Associate Director (AD), BiostatisticsDepartment: Development - Data ScienceReports To: Director, BiostatisticsLocation: South San Francisco, CA or Princeton, NJ