Senior Research Associate in Protein Science Developability

Your Role at Lila Sciences Lila Sciences is searching for a skilled Senior Research Associate with expertise in Protein Purification, Analytics, and Developability. You will play a crucial role in the establishment and daily functioning of a cutting-edge high-throughput protein characterization platform. This position involves optimizing biophysical characte…

Join Lila Sciences as a Senior Research Associate or Associate Scientist in the Protein Science department, focusing on our cutting-edge Antibody Platform. You will play a crucial role in advancing our research initiatives, contributing to the development of innovative antibody-based therapeutics. This position offers the opportunity to collaborate with a talented team dedicated to scientific excellence and the pursuit of transformative solutions in healthcare.

Join Lila Sciences as a Research Associate specializing in Protein Science and Cell Free Expression. In this dynamic role, you will contribute to groundbreaking research, collaborating with a talented team to develop innovative solutions in protein production and expression technologies.

Nuclera develops technology to make proteins more accessible for researchers. Based in Cambridge, UK, with a presence in Boston, the company’s eProtein Discovery™ platform brings together a benchtop instrument, cloud-based software, and proprietary cartridges. This system supports rapid protein expression, characterization, and purification for life science teams around the world. Role overview The Research Associate in Service Fulfillment supports custom scientific projects and DNA construct amplification using the eProtein Discovery Platform. The role requires careful adherence to Standard Operating Procedures (SOPs) and detailed work instructions to maintain quality and consistency. Success in this position calls for strong organizational skills, attention to detail, and the ability to work independently within set timelines. What you will do Prepare DNA constructs for cell-free protein expression using PCR techniques. Perform protein purification, quantification, SDS PAGE analysis, and either gel filtration chromatography or Surface Plasmon Resonance (SPR) analysis. Run experiments with the eProtein Discovery Platform. Follow established SOPs and work instructions to ensure quality standards are met. Organize and manage large collections of biological samples in a systematic way. Document experimental methods, observations, and results with precision.

Flagship Pioneering brings together scientists and entrepreneurs to launch companies that address major challenges in health, sustainability, and technology. The organization supports innovators with capital and resources, helping them advance projects in disease detection, treatment, agriculture, and artificial intelligence. Flagship’s portfolio companies have contributed to global vaccination efforts, developed new therapies, and improved agricultural sustainability. The company has received recognition from FORTUNE and Fast Company for its impact and innovation. Role overview The Senior Research Associate in Formulation Development will join a team focused on designing and optimizing dried powder formulations. This position centers on hands-on work with techniques such as lyophilization and spray drying, supporting early-stage platform development. The role calls for experimental precision, strong data analysis, and a collaborative approach to problem-solving. What you will do Design, execute, and refine dried powder formulations using lyophilization and spray drying methods. Prioritize stability, reproducibility, and performance across different formulation types. Collaborate with process development teams to ensure powder formulations are stable and scalable. Develop experimental plans, interpret data, and help establish best practices for formulation screening, characterization, and documentation. Requirements Experience with formulation development, especially dried powders. Hands-on skills in lyophilization and spray drying. Ability to design experiments, analyze results, and document findings. Comfort working in an early-stage, collaborative environment.

Join our innovative team at Flagship Pioneering Inc., where we are at the forefront of therapeutic discovery. As a Senior Research Associate, you will play a critical role in advancing our understanding of novel therapeutic pathways and contribute to groundbreaking research in the life sciences.

We are seeking a highly motivated Senior Research Associate to join our dynamic team at Integrated Resources, Inc. In this pivotal role, you will conduct advanced research, analyze data, and contribute to innovative projects that drive our mission forward. If you are passionate about scientific research and eager to make an impact, we want to hear from you!

We are seeking a talented and dedicated Senior Research Associate to join our dynamic team in Cambridge. In this role, you will contribute to innovative research projects and collaborate with interdisciplinary teams to drive impactful findings.

Your Contribution at Lila Sciences Lila Sciences is actively seeking a dedicated (Senior) Research Associate to become an integral part of our dynamic Life Sciences team. This pivotal role will be centered around the formulation of lipid nanoparticles (LNPs), their functionalization with targeting ligands, and the characterization of the resulting targeted LNPs (tLNPs). The ideal candidate will possess substantial hands-on experience in LNP formulation and characterization, bioconjugation, protein characterization, and automation technologies. Your expertise will significantly enhance our understanding of the delivery space, enabling a high-throughput closed-loop screening cascade for tLNPs. You will work collaboratively with professionals across protein, cell biology, automation, chemistry, machine learning, and data science teams to establish advanced tools for targeted nucleic acid delivery. Your Key Responsibilities Design, execute, and characterize LNP formulations utilizing various scales and mixing modalities (e.g., DLS, ribogreen, TNS). Develop and optimize high-throughput ligand conjugation and purification methodologies, leveraging automation and robotics to maximize throughput. Collaborate with cell assay and antibody experts to screen candidates across diverse tissue targets in in vivo models. Engage with chemists, biologists, engineers, and data scientists to document processes, share insights, and refine best practices in autonomous flow chemistry. Create, implement, and uphold Standard Operating Procedures (SOPs) for both existing and emerging lab processes. Your Qualifications for Success MSc in Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences, or a closely related field with 3+ years of hands-on experience in targeted LNP production or a BSc with 5+ years of relevant experience. Industry experience is highly desirable. Strong proficiency in bioanalytical techniques (e.g., DLS, fluorescence spectroscopy, electrophoresis, in vitro assays). Experience in protein and antibody design and characterization. Familiarity with automation and high-throughput workflows is preferred. Exceptional troubleshooting, communication, and collaboration skills, with a proven ability to work effectively across interdisciplinary teams. About Lila Sciences Lila Sciences is at the forefront of innovation as the world's first scientific superintelligence platform and autonomous laboratory focused on life sciences, chemistry, and materials science. We are pioneering a new era of limitless discovery by harnessing AI capabilities to enhance every facet of the scientific method. Our mission is to leverage scientific superintelligence to address humanity's most pressing challenges.

Your Impact at Lila Sciences Join our innovative high-throughput autonomous chemistry team as a Senior Research Associate / Associate Scientist. This hands-on position bridges the fields of organic and inorganic synthesis, advanced characterization, and laboratory automation. You will design and implement high-throughput experiments, synthesize small molecules, and conduct thorough downstream analysis alongside senior scientists. Your efforts will contribute to translating ambitious product objectives into scalable experimental workflows that significantly influence our company's growth. This role provides a unique opportunity to engage with automated chemistry platforms, giving you real ownership of experiments that shape our scientific strategy and direction. Ideal candidates are execution-oriented, excel in dynamic laboratory settings, and are passionate about developing deep technical skills while making impactful contributions to the future of chemical discovery at Lila Sciences. What You’ll Be Building Independently conduct experiments for the synthesis, purification, and characterization of organic and inorganic small molecules. Optimize reactions, develop methodologies, and analyze analytical data to inform project decisions. Convert initial concepts into reliable, functional experiments. Utilize retrosynthetic analysis to assist in the synthesis of target molecules. Operate Schlenk lines, gloveboxes, and various inert-atmosphere systems for sensitive materials. Employ PAT tools (UPLC, LCMS, NMR, IR, Fluorescence, DLS) to monitor reactions, ensure quality control, and produce high-quality data for machine learning workflows. Leverage automation and AI-driven technologies to streamline workflows and reduce experimental turnaround times. Collaborate with engineers, ML scientists, and stakeholders to validate model-recommended conditions, analyze trends, troubleshoot challenges, and clearly communicate results through reports, discussions, and presentations. Maintain meticulous documentation of results, ensuring accurate digital records while adhering to EHS and laboratory best practices. What You’ll Need to Succeed M.S. in Chemistry or a related field (such as organic, organometallics, or catalysis) with a minimum of 2 years of relevant laboratory experience, or a B.S. with 5 years of experience. Hands-on experience in organic and inorganic synthesis, purification processes, chromatographic techniques, and product analysis. Strong grasp of retrosynthesis, reaction mechanisms, and method optimization workflows. Proficiency in utilizing laboratory automation tools and systems. Excellent problem-solving skills and the ability to work collaboratively in a team-oriented environment.

Join Integrated Resources, Inc. as a Pharmaceutical Research Associate, where you will play a vital role in advancing medical research and drug development. You will collaborate with a team of scientists and researchers to assist in the design and execution of clinical trials, ensuring the integrity and accuracy of data collection.Your contributions will help pave the way for innovative therapies that make a difference in patients' lives. Ideal candidates are detail-oriented, possess strong analytical skills, and have a passion for the pharmaceutical industry.

Join our dynamic team at Integrated Resources Inc. as a Senior Neurology Research Associate, where you will play a pivotal role in advancing groundbreaking research in neurology. You will collaborate with top-tier professionals, contributing to innovative projects that drive the future of neurological health.

Your Contribution at Lila At Lila, we are assembling a highly skilled and proactive AI safety team that will collaborate with all core departments, including science, model training, and lab integration, to effectively address risks associated with scientific superintelligence. The primary mission of this team is to develop and execute a tailored safety strategy that aligns with Lila's unique objectives and deployment methodologies. This will encompass formulating technical safety strategies, engaging with the broader ecosystem, and producing technical documentation such as risk and capability assessments and safety measures. Your Responsibilities Establish the research and development strategy for Lila’s safety framework concerning biological and physical risks. Design and implement capability evaluations to identify scientific risks (both recognized and novel) arising from state-of-the-art scientific models integrated with automated physical laboratories across biological and physical sciences. Lead and coordinate threat modeling sessions with both internal and external scientific experts, including monitoring advancements in technologies and their applications. Create and curate high-quality training and testing datasets for evaluations and safety systems. Assess risks linked to Lila’s capabilities, considering interactions with the broader ecosystem of capabilities (including general-purpose frontier models and specialized scientific tools). Contribute to extensive, high-quality research initiatives when needed for scientific capability evaluation and restriction. Engage in external communications regarding Lila’s safety initiatives. Qualifications for Success A PhD in a biological sciences field (e.g., molecular biology, virology, computational biology) or a physical sciences field (e.g., materials science, physics, chemistry, chemical or nuclear engineering) or equivalent experience. Proven track record in setting research directions for open issues surrounding dual-use risks in biological and physical sciences. Experience in scientific computing within the biological or physical sciences. Understanding of dual-use research and dissemination issues in relation to relevant safety, regulatory, and governance frameworks (e.g., export controls, biological and chemical-related conventions). Excellent communication skills, capable of articulating complex technical concepts to non-specialist audiences. Demonstrated leadership capabilities in guiding teams of internal and external collaborators in developing Lila's perspective on biological and physical risks.

Join Lila Sciences as a Senior Associate in Corporate Development, where you'll play a pivotal role in driving strategic growth initiatives. In this dynamic position, you will collaborate with cross-functional teams to identify, evaluate, and execute new business opportunities that align with our corporate objectives. Your analytical skills will be crucial in conducting market research, financial modeling, and competitive analysis to support decision-making processes.

Flagship Pioneering, Inc. is seeking a Senior Research Associate in Chemical Biology for its FL116 team in Cambridge, MA. FL116 is dedicated to advancing biomolecule synthesis and is building a platform to transform the manufacturing of research, diagnostic, and therapeutic molecules. Role overview This position joins a collaborative group focused on applying chemical strategies to biological questions. The work centers on enzyme-mediated biomolecular synthesis, with careful attention to both mechanistic and molecular aspects. Main responsibilities Design and execute high-throughput experiments to investigate enzyme-substrate interactions Characterize biomolecular products using a range of established and new analytical methods Contribute to the development of scalable assays that support the growth of the platform Requirements Strong hands-on experimental skills and a close attention to detail Curiosity about the chemical nature of biological systems Interest in manipulating and measuring biological activity at the molecular scale Comfort working in an execution-focused, pipeline-driven environment Motivation to develop with a rapidly evolving technology platform Work environment The role provides the opportunity to deepen expertise at the intersection of chemistry and biology in a collaborative startup setting, supported by Flagship Pioneering. The team values problem solvers who enjoy tackling complex scientific challenges and building new tools for biotechnology and therapeutics.

Lila Sciences seeks an Associate Engineer to join the Research Operations team in Cambridge, MA. This team develops high-throughput methods that support scientific discovery across multiple disciplines. The position centers on hands-on work with materials characterization, using advanced tools such as spectroscopy and microscopy. This role provides direct exposure to automation technologies while supporting projects that influence the company’s direction. It suits candidates interested in expanding their engineering skills and building a strong base in scientific operations. Key responsibilities Perform materials characterization using SEMXRF, XRD, Optical Microscopy, Nanoindentation, and Profilometry. Prepare reagents, solutions, electrolytes, samples, and consumables to support experiments across shifts. Follow standard operating procedures to maintain accuracy and consistency. Monitor workflow, troubleshoot routine issues, and escalate concerns to keep operations steady between shifts. Record and organize experimental data with care. Identify and suggest ways to improve efficiency and streamline shift operations. Report unusual results or observations to scientists for review. Collaborate with scientists and engineers on projects spanning life sciences and physical sciences. Location This position is based in Cambridge, MA, USA.

We are seeking a detail-oriented and motivated Research Associate to join our dynamic team at Integrated Resources, Inc. As a Research Associate, you will play a pivotal role in conducting research, analyzing data, and supporting various projects that contribute to the advancement of our organization’s goals.Your responsibilities will include collaborating with cross-functional teams, preparing reports, and presenting findings to stakeholders. This position offers an excellent opportunity for professional growth and development in a fast-paced environment.

Join our team at Integrated Resources Inc. as an Associate Research Scientist, where you will contribute to cutting-edge research projects that impact real-world applications. We are looking for passionate individuals eager to innovate and collaborate in a dynamic environment. In this role, you will support senior scientists in the design and execution of experiments, analyze data, and contribute to publications. This is a fantastic opportunity to grow your career in scientific research.

Fathem develops tools that help scientists visualize and interpret biology at the molecular level. The company integrates cryo-electron microscopy (cryo-EM), artificial intelligence, advanced hardware, and automation to make molecular structures more accessible and speed up drug discovery. As part of Flagship Pioneering, Fathem draws on substantial resources to reshape how biology is explored and applied. Role overview The Senior Research Associate - Cryo-EM will play a key part in refining and executing cryo-EM workflows. This hands-on position focuses on preparing high-quality cryo-EM grids and datasets from a variety of biomolecular samples, including soluble proteins, membrane proteins, and nanoparticles. The role requires close collaboration with protein biochemistry, structural biology, and computational teams to ensure reliable grid preparation and imaging processes that feed into advanced computational modeling. Success in this position means solving complex biochemical challenges and seeing direct impact on scientific outcomes. What you will do Prepare cryo-EM grids and collect data from diverse biomolecular systems, maintaining efficiency and high standards for dataset quality. Carry out the full cryo-EM process, including grid vitrification, screening, and high-throughput data acquisition using Thermo Fisher microscopes. Operate and improve workflows to ensure reproducible, scalable data generation and increase throughput and reliability. Adjust and optimize protocols for challenging samples, refining grid preparation and imaging methods to boost success rates. Run experiments for external partners and clients, ensuring datasets align with project requirements. Work closely with protein science and computational teams to integrate cryo-EM data into broader research projects. Location This position is based in Cambridge, MA, USA.

Your Impact at Lila Join our dynamic and innovative AI safety team at Lila Sciences, where we prioritize talent and agency to mitigate risks associated with scientific superintelligence. Our mission is to craft and execute a tailored safety strategy that aligns with our unique objectives and deployment methods. This role involves creating technical safety strategies, engaging with the broader scientific community, and producing critical technical documentation, including evaluations focused on risk and capability assessments. What You’ll Be Creating Design and implement capability evaluations to assess scientific risks, particularly from cutting-edge scientific models integrated with automated physical laboratories across biological and physical sciences. Lead and coordinate threat modeling sessions with both internal and external scientific experts, keeping abreast of emerging technologies and use cases. Develop and manage high-quality training and testing datasets for evaluations and safety systems. Analyze risks associated with Lila’s capabilities and their interactions with the broader ecosystem of general-purpose frontier models and specialized scientific tools. Contribute to high-quality research initiatives focused on scientific capability evaluation and restriction as needed. Assist with external communications regarding Lila’s safety initiatives. What You’ll Need to Succeed A PhD in biological sciences (e.g., molecular biology, virology, computational biology) or physical sciences (e.g., materials science, physics, chemistry, or chemical engineering), or similar experience. Proficient in scientific computing related to biological or physical sciences. Familiarity with dual-use research and dissemination issues within relevant safety, regulatory, and governance frameworks (e.g., export control, biological and chemical conventions). Exceptional communication skills to convey complex technical concepts to non-expert audiences effectively. Proven ability to lead internal and external teams in developing Lila's perspective on biological and physical risks. Demonstrated capacity to collaborate with cross-functional stakeholders (science, AI, product, policy) in a complex environment.