Scientist II, Structural Biology

Revolution Medicines is a pioneering clinical oncology enterprise focused on developing innovative targeted therapies for patients battling RAS-addicted cancers. Our research and development pipeline includes advanced RAS(ON) inhibitors aimed at inhibiting various oncogenic RAS protein variants. Our lead candidates currently in clinical trials include daraxo…

Join Revolution Medicines, a pioneering biopharmaceutical company dedicated to developing innovative therapies for cancer patients. As a Structural Biology Intern, you will have the opportunity to work alongside a talented team of scientists and contribute to groundbreaking research. This internship will provide hands-on experience in structural biology techniques, including protein crystallization and X-ray crystallography.

Join Revolution Medicines as a Scientist II, specializing in drug product development. In this critical role, you will leverage your scientific expertise to contribute to innovative drug formulation and delivery systems. Collaborate with a talented team dedicated to advancing groundbreaking therapies that improve patients' lives.

Join Revolution Medicines as a Scientist II specializing in Drug Metabolism and Pharmacokinetics (DMPK), where you will play a crucial role in advancing our innovative therapeutic programs. In this position, you will collaborate with a dynamic team of scientists to design and execute experiments that contribute to the development of cutting-edge treatments. Your expertise in DMPK will help us understand how our drug candidates behave in biological systems, ensuring their efficacy and safety.

Join Revolution Medicines, Inc. as a Scientist II specializing in Cancer Pharmacology within our Translational Research team. In this pivotal role, you will contribute to groundbreaking research aimed at developing innovative cancer therapies. Your expertise will drive the advancement of our clinical pipeline, helping to bridge the gap between preclinical studies and clinical application.

Join Revolution Medicines as a Computational Biology Intern and immerse yourself in groundbreaking research that is transforming cancer treatment. This internship offers a unique opportunity to collaborate with a dynamic team focused on innovative drug discovery methods.As an intern, you will assist in analyzing biological data, developing computational models, and contributing to projects that push the boundaries of our understanding of cancer biology. Your contributions will play a vital role in advancing our mission to improve patient outcomes through precision medicine.

Revolution Medicines develops targeted therapies for patients with RAS-addicted cancers. The company’s clinical pipeline features several RAS(ON) inhibitors, including daraxonrasib (RMC-6236), elironrasib (RMC-6291), zoldonrasib (RMC-9805), and RMC-5127. The team focuses on advancing treatments for cancers driven by mutations in the RAS signaling pathway. Role overview The Director of Target Biology leads the Target Biology team within the Targets and Mechanisms group in Discovery Biology. This group combines expertise in cancer biology and mechanistic understanding of cancer pathways to identify and analyze oncology targets for the tri-complex inhibitor (TCI) platform. Key responsibilities Lead the Target Biology team, providing both scientific direction and personnel management. Work with cross-functional teams to identify and evaluate high-priority oncology targets for the TCI platform. Develop and execute strategies for hit identification. Oversee the progression of screening hits through early hit-to-lead discovery stages. Requirements Extensive experience in oncology drug discovery, with a focus on target identification for oncology programs. Demonstrated strategic thinking and leadership in scientific settings. Knowledge of various targeting modalities, including molecular glues. Direct experience advancing projects from hit identification through hit-to-lead development. Location This position is based in Redwood City, California, United States.

Revolution Medicines, Inc. is seeking a dynamic and experienced Executive Director of Computational Systems Biology to lead our innovative efforts in drug discovery and development. In this pivotal role, you will direct a team of computational biologists and bioinformaticians, guiding the integration of cutting-edge computational techniques with experimental biology to advance our understanding of disease mechanisms and therapeutic strategies.The ideal candidate will possess deep expertise in computational biology, a proven track record in leading research teams, and a passion for transforming scientific discoveries into therapeutic solutions. You will collaborate with cross-functional teams to drive strategic initiatives and spearhead projects that will shape the future of our pipeline.

Join Poshmark, a leading social commerce platform, as a Staff Data Scientist. In this pivotal role, you will leverage your expertise in data analysis and machine learning to drive insights and innovations that enhance our platform and user experience. You'll work collaboratively with cross-functional teams to develop robust models, implement data-driven strategies, and contribute to the evolution of our analytics capabilities.

At Retro, we are pioneering innovative therapies that target age-related diseases. Our focus is on cellular reprogramming and autophagy to restore cell and tissue vitality, aiming to add a decade to the healthy human lifespan.We are assembling a passionate, mission-driven team of talented individuals who thrive in our dynamic startup environment characterized by rapid innovation, transparency, and adaptability.We are on the lookout for an ambitious Scientist specializing in Genomics to develop and optimize platforms that facilitate the discovery of therapies aimed at rejuvenating cellular and tissue functions. You will manage sequencing workflows from start to finish, collaborating closely with automation and computational scientists to scale your innovations and generate crucial data for our advanced models.

Revolution Medicines, Inc. seeks a Safety Scientist based in Redwood City, California. This role centers on supporting the safety and effectiveness of therapies under development. The Safety Scientist works with colleagues from various disciplines to review safety data, conduct evaluations, and assist with regulatory filings. What you will do Work with internal teams to assess and monitor safety profiles of therapies in development. Analyze safety data from both clinical and preclinical studies. Help prepare documents needed for regulatory submissions. Role impact This position plays a part in shaping new therapies and influencing the future of medicine by ensuring careful safety evaluation and strong collaboration across teams.

Join our innovative team at Adverum Biotechnologies, Inc. as a Clinical Scientist/Senior on a contract basis. You will play a pivotal role in designing and implementing clinical trials, analyzing data, and collaborating with cross-functional teams to advance our gene therapy products. Your expertise will contribute to impactful research that aims to transform patient care and improve outcomes.

Revolution Medicines develops targeted therapies for patients with RAS-addicted cancers. The company’s pipeline includes several RAS(ON) inhibitors currently in clinical development, such as Daraxonrasib (RMC-6236), Elironrasib (RMC-6291), Zoldonrasib (RMC-9805), and RMC-5127. The team is dedicated to advancing treatments for cancers driven by mutations in the RAS signaling pathway. Role overview The Senior Safety Scientist will join the Global Patient Safety Science group, supporting pharmacovigilance and safety science activities across both early and late-stage clinical programs. This position covers the full portfolio of Revolution Medicines’ investigational therapies. Key responsibilities Oversee safety for clinical studies, including reviewing and authoring protocols, Investigator's Brochures (IBs), Informed Consent Forms (ICFs), and Development Safety Update Reports (DSURs). Conduct medical review of individual case safety reports (ICSRs) and monitor safety surveillance for assigned products. Proactively perform medical safety surveillance during clinical trials to identify and address safety issues. Prepare and present safety data summaries to internal and external stakeholders. Engage in risk management activities, including routine safety data analysis, medical review of ICSRs, and literature review. Share knowledge on drug class safety issues and competitor landscape. Identify potential clinical safety concerns and recommend risk mitigation strategies. Contribute to preparation and maintenance of clinical trial protocols, IBs (including reference safety information), ICFs, DSURs, Risk Management Plans (RMPs), Core Content Development Summaries (CCDS), and product labeling. Review clinical protocols, IBs, ICFs, and related documents to ensure alignment with safety strategies. Location This role is based in Redwood City, California, United States.

Join us at Retro, a pioneering leader in the field of regenerative medicine, as we seek a dedicated Scientist specializing in iPSC Differentiation with a focus on Hematopoiesis. In this role, you will harness your expertise to drive innovative research and contribute to our mission of advancing human health through cutting-edge science.

Join our innovative team at Integrated Resources, Inc. as a Data Scientist / Computational Biologist. In this role, you will leverage your scientific expertise and analytical skills to drive data-driven solutions in the field of biology. Collaborating with cross-functional teams, you will analyze complex biological data, develop predictive models, and contribute to groundbreaking research.

Join Our Innovative TeamAt GridCARE, we tackle the critical challenges faced by data center developers, primarily the urgent need for immediate access to power. Our groundbreaking physics-based generative AI platform enables us to unlock gigawatts of near-term capacity from the existing electrical grid. By collaborating with utilities and implementing our unique strategies, we enhance network capacity without the need for expensive upgrades or prolonged delays. Founded at Stanford’s Doerr School and supported by top investors in the fields of Energy and AI, we are partnering with leading technology and data center firms to expedite interconnection requests for substantial data center projects.As a rapidly expanding startup, we are in search of a talented Data Scientist who is passionate about crafting data-driven solutions with significant real-world impact. Role OverviewWe are looking for a Data Scientist who excels at bridging the gap between business and technology — a professional adept at translating complex datasets into clear, actionable insights for both internal teams and external clients.In this position, you will work closely with GridCARE’s business and engineering teams to create high-quality visualizations and analyses that enhance customer interactions and facilitate the delivery of impactful projects. Your responsibilities will include crafting interactive maps, dashboards, and analytical visuals that highlight project outcomes, grid capacity opportunities, and results from power system studies.This is a unique opportunity to integrate advanced data science and visualization skills with cutting-edge AI solutions to address the pressing need for power in the energy sector.

Adverum Biotechnologies, Inc. is seeking a passionate and detail-oriented Process Development Scientist to join our innovative team on a contract basis. In this role, you will be responsible for developing and optimizing processes for the production of gene therapies. You will collaborate with cross-functional teams to ensure the successful transition of processes from development to clinical manufacturing.

Adverum Biotechnologies, Inc. is seeking a talented and motivated Technical Development Scientist to join our dynamic team on a contract basis. In this role, you will contribute to the development and optimization of innovative gene therapies aimed at treating serious ocular diseases. Your expertise will play a critical role in advancing our cutting-edge projects and ensuring the success of our therapeutic candidates.

Join Revolution Medicines as a Senior Scientist I in Computational Chemistry, where you will play a pivotal role in advancing our drug discovery efforts. As part of our dynamic and innovative team, you will leverage your expertise in computational approaches to support the design and optimization of small molecules. Collaborate with cross-functional teams to drive projects from concept through to preclinical development, contributing to our mission of transforming the lives of patients with cancer.

DatologyAI develops tools that improve machine learning model performance by focusing on the quality of training data. Many organizations invest heavily in processing data that can be redundant or irrelevant, which often leads to costly models that do not perform well in real-world scenarios. To address this, DatologyAI offers a data curation suite that automatically selects and optimizes large datasets. With this approach, organizations can significantly reduce training times, sometimes by a factor of 7 to 40, while training smaller models that outperform much larger ones. Curated data can also lower deployment costs and, in some cases, allow models to achieve results similar to having access to ten times more raw data, using less than half the parameters. The company has raised $57.5 million across two funding rounds. Backers include Felicis Ventures, Radical Ventures, Amplify Partners, Microsoft, Amazon, and prominent AI researchers such as Geoff Hinton, Yann LeCun, and Jeff Dean. The team brings together expertise in data optimization research and practical engineering to make advanced data curation widely accessible. Role overview This Research Scientist position is based in Redwood City, CA. The team collaborates in the office four days a week.