Principal Scientist in Medicinal Chemistry

Role Overview iambic therapeutics is seeking a Principal Scientist in Medicinal Chemistry to join the team onsite at our San Diego headquarters. This role calls for an accomplished medicinal chemist who brings a strong track record in drug discovery and thrives in a collaborative, multidisciplinary setting. The position involves close interaction with teams …

Join AbbVie, a global biopharmaceutical company, as a Principal Research Scientist II specializing in Lipid Chemistry. In this critical role, you will drive innovative research initiatives that advance our understanding of lipid biology and contribute to the development of cutting-edge therapeutics. You will collaborate with cross-functional teams to translate scientific discoveries into actionable insights.

Job SummaryIambic Therapeutics is looking for an exceptional and driven Senior Associate Scientist to enhance our Chemistry team at our San Diego headquarters. This exciting position allows you to thrive in a vibrant, cross-disciplinary environment, where you will collaborate closely with medicinal chemists, biologists, DMPK scientists, computational chemists, machine learning experts, and software engineers. You will engage in every phase of the discovery process, from hit identification and lead optimization to candidate selection. This role is laboratory-focused and demands robust technical skills in organic synthesis, catalysis, and medicinal chemistry, alongside hands-on experience in the drug discovery process and a proven “drug hunter” mentality.Key ResponsibilitiesDesign, synthesize, purify, and characterize chemical compounds (10 mg–5 g scale) utilizing cutting-edge analytical techniques including LCMS, HPLC, and NMR, implementing both manual and automated parallel synthesis techniques.Identify and optimize reaction conditions through the use of screening kits and other efficient methodologies.Collaborate with the high-throughput experimentation team to guarantee successful execution of parallel chemistry experiments.Analyze biological and ADME-PK data using cheminformatics tools and contribute to data-driven discussions and strategic planning.Work alongside computational chemists to harness machine learning insights for the effective execution of the design–make–test cycle and platform development.Present findings to project teams and senior leadership, effectively communicating data, implications, and recommendations.QualificationsBS in Chemistry with 5+ years of experience in the pharmaceutical or biotechnology sector, or MS in Chemistry with 3+ years of relevant experience.Demonstrated expertise in multi-step organic synthesis, reaction optimization, Structure-Activity Relationship (SAR) analysis, and effective scientific presentation skills.Adeptness in a fast-paced, highly collaborative research atmosphere.Willingness to work onsite in San Diego.Preferred QualificationsExperience in high-throughput experimentation is advantageous.Familiarity with ADME-PK principles is a plus.5+ years of experience contributing to drug discovery projects is preferred.

JOB SUMMARYIambic Therapeutics is on the lookout for a talented and highly motivated Senior/Principal Scientist specializing in Computational Chemistry to join our innovative Computational Sciences team at our San Diego headquarters. As a vital contributor, you will leverage advanced ligand and structure-based methodologies to propel our drug discovery initiatives. You will actively engage with research teams focused on developing groundbreaking therapeutics across various indications. Collaborating closely with experts in machine learning, medicinal chemistry, and biology, you will implement state-of-the-art Structure-Based Drug Design (SBDD) techniques throughout hit identification, lead optimization, and candidate selection phases. This hands-on position demands robust expertise in computational chemistry, a keen interest in co-folding applications, and a proactive drug-hunter mindset.KEY RESPONSIBILITIESUtilize diverse ligand and structure-based strategies during the hit identification, lead optimization, and candidate selection phases (including cheminformatics, pharmacophore modeling, docking, shape-based virtual screening, de novo molecular design, and molecular dynamics simulations).Lead design cycles by identifying structure-activity relationships and integrating computational predictions with bioactivity data.Collaborate with medicinal chemists to design, assess, and prioritize virtual libraries, proposing concrete molecular designs.Work alongside machine learning scientists to meld SBDD methodologies with our proprietary transformer-based property prediction technology (Enchant).Enhance and utilize our proprietary protein-ligand co-folding technology (NeuralPLexer) to generate novel and actionable structural hypotheses.Translate scientific inquiries into computational workflows, delivering actionable insights.Present findings to project teams, elucidating methods, implications, and recommendations.Develop, validate, and maintain computational workflows and tools.QUALIFICATIONSRequired:PhD or equivalent in Computational Chemistry (or a related field) with a minimum of 5 years of experience in an industrial drug discovery setting.Proven experience in supporting active small molecule drug discovery programs.Experience with ligand and structure-based drug design methodologies.

Role Overview iambic therapeutics seeks a Director or Senior Director of Medicinal Chemistry to guide drug discovery efforts from our San Diego headquarters. This leadership role calls for deep experience in medicinal chemistry and a strong record of moving drug discovery programs forward. The position sits at the center of scientific strategy and team leadership within a multidisciplinary setting. What You Will Do Oversee drug discovery projects from early-stage concepts through key milestones Lead, mentor, and develop a team of medicinal chemists Coordinate resources across internal teams and external partners Work closely with groups specializing in automated experimentation, machine learning-based molecular design, property prediction, and bioassay data analysis Location This role is based onsite at our San Diego headquarters.

Genesis Therapeutics is seeking an innovative and experienced Associate Director/Director of Medicinal Chemistry to join our dynamic team in San Diego, CA. In this leadership role, you will spearhead the design and optimization of novel therapeutic compounds, driving the discovery process from initial concept through to clinical candidates.The ideal candidate will have a robust background in medicinal chemistry and a proven track record of leading successful drug discovery projects. You will collaborate closely with cross-functional teams, fostering an environment of creativity and scientific excellence.

Genesis Therapeutics is seeking a highly experienced Senior Director of Medicinal Chemistry to lead our innovative research team in San Diego, California. In this pivotal role, you will drive the advancement of our drug discovery initiatives, leveraging your extensive expertise in medicinal chemistry to develop novel therapeutic compounds that address unmet medical needs.As a key member of our leadership team, you will collaborate closely with cross-functional teams to guide the design and optimization of small molecules. Your strategic vision and scientific acumen will be crucial in shaping our research agenda and ensuring the successful progression of projects from concept to clinical development.

Join Genesis Molecular AI as an Associate Director/Director of Medicinal Chemistry, where you will play a pivotal role in utilizing our cutting-edge AI platform to spearhead drug discovery initiatives, guiding projects from Hit Identification through to candidate nomination. Collaborate with multidisciplinary teams to shape the medicinal chemistry vision and drive innovative solutions in drug development.Key Responsibilities:Develop and implement medicinal chemistry strategies using the Genesis platform for drug discovery from Hit ID through to candidate nomination.Apply Structure-Based Drug Design (SBDD) methodologies, optimize physicochemical properties, and analyze in vitro and in vivo ADME/PK/Toxicology data to advance programs.Leverage data visualization tools and metrics to formulate medicinal chemistry hypotheses and prioritize approaches effectively.Foster communication and collaboration with industry partners on drug discovery initiatives.Engage with diverse drug discovery teams (biology, DMPK, software engineers, computational chemists) to drive data-driven decisions, enhance platform capabilities, and uphold scientific excellence.Maintain regular communication with project team members and management to ensure alignment and progress.

We are seeking a highly skilled Senior Director of Medicinal Chemistry to join our innovative team at Genesis Molecular AI. In this pivotal role, you will leverage our cutting-edge platform to spearhead medicinal chemistry initiatives that drive drug discovery from Hit Identification to candidate nomination. You will be a key collaborator and leader in multidisciplinary drug discovery projects, shaping the medicinal chemistry strategy for each project. As a recognized leader in medicinal chemistry, you will possess exceptional communication skills, facilitating collaboration with both internal teams and external partners.Key ResponsibilitiesDevelop and implement medicinal chemistry strategies utilizing the Genesis platform to effectively manage drug discovery programs from Hit ID through to candidate nomination.Apply Structure-Based Drug Design (SBDD) principles, optimize physicochemical properties, and interpret in vitro and in vivo ADME/PK/Toxicology data to advance projects.Employ data visualization software and metrics-driven analysis to formulate medicinal chemistry hypotheses and prioritize project strategies.Engage and collaborate with industry partners on various drug discovery projects.Work closely with other drug discovery disciplines, including biology, DMPK, software engineering, and computational chemistry, to foster hypothesis-driven decisions and enhance platform capabilities.Maintain regular communication and engagement with project teams and management to ensure alignment and progress.Mentor and guide internal chemists and other scientific professionals on medicinal chemistry best practices.

As a Staff Scientist at Scripps Research, you will have the opportunity to contribute to cutting-edge research in organic chemistry. Your responsibilities will be tailored to the specific laboratory and the Principal Investigator's needs. You will engage in laboratory management, assist in grant editing and reporting, maintain LC-MS systems, support collaborations with the Principal Investigator and graduate students, and organize chemical libraries while developing click chemistry methodologies.

At Bee Genius, we are pioneering the future of work, today.This post was generated on behalf of our client:Job Description: We are seeking a highly accomplished and motivated Principal Scientist to become an integral part of our innovative team. In this role, you will spearhead groundbreaking scientific research and development initiatives, offer expert technical guidance, and catalyze innovation within our organization.Responsibilities:Lead and oversee scientific research projects from conception through to execution.Design and refine scientific methodologies and protocols for optimal outcomes.Conduct thorough analysis and interpretation of intricate data, effectively presenting insights to stakeholders.Mentor and provide technical support to junior scientists, fostering their professional growth.Collaborate with cross-functional teams to convert scientific discoveries into actionable applications.Remain abreast of the latest advancements and industry trends in your field.

At Genesis Molecular AI, we are on a mission to transform the landscape of drug discovery by forming a premier computational chemistry team that leverages advanced machine learning techniques and biophysical simulations. We are actively looking for a Principal CADD Scientist to collaborate with our scientists in our cutting-edge wet lab and coordinate with our remote computational chemistry and CADD science teams throughout the United States.Key ResponsibilitiesEmploy both established and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse range of targets, including innovative targets with minimal chemical precedents.Implement strategies such as virtual screening, molecular simulations, and predictive analytics for potency and ADMET to inform critical decision-making in drug development.Work collaboratively with medicinal chemists on molecular design and the formulation of project-specific computational methodologies.Serve as a liaison among teams, ensuring effective communication between computational chemistry and medicinal chemistry groups to facilitate seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that fosters innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. This role is also suitable for PhD-level professionals in organic or medicinal chemistry with substantial lab experience who have transitioned into CADD roles.In-depth knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.A minimum of 5 years of relevant industry experience as a CADD scientist in pharmaceuticals or biotechnology, with direct involvement in active drug discovery projects.While onsite presence in our San Diego lab is preferred for collaboration, we welcome applicants interested in remote opportunities.What We OfferCompetitive salary and benefits packageComprehensive health care plans (including medical, dental, and vision, fully covered for employees)Eligibility for stock options

We are seeking a dedicated and innovative Principal Research Scientist II to join our Analytical Development team at AbbVie in San Diego. In this pivotal role, you will lead analytical strategies for drug development, collaborating with cross-functional teams to ensure the successful progression of our therapeutic candidates. You will leverage your expertise in analytical methods to contribute to regulatory submissions and provide scientific guidance throughout the product lifecycle.

Genesis Molecular AI is on a mission to transform drug discovery through innovative computational chemistry solutions. We are building a premier team of experts in computational chemistry, and we invite you to join us as a Senior CADD Scientist. In this pivotal role, you will collaborate closely with our cutting-edge wet lab scientists and work alongside our distributed computational chemistry and CADD science teams throughout the United States.Key Responsibilities:Employ a blend of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a varied target landscape, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and potency and ADMET prediction to facilitate critical decision-making processes in drug discovery.Work collaboratively with medicinal chemists to design molecules and develop tailored computational strategies for specific projects.Serve as a bridge among teams, effectively communicating between our computational chemistry and medicinal chemistry groups to promote seamless information exchange and collaborative decision-making.Thrive in a dynamic environment that encourages innovation and rapid iteration.

At Genesis Molecular AI, we are assembling a premier computational chemistry team dedicated to transforming drug discovery through state-of-the-art machine learning and biophysical simulations. We invite applications for the role of Principal CADD Scientist, who will collaborate closely with our scientists in the advanced wet lab and our distributed computational chemistry and CADD teams located across the United States.Key ResponsibilitiesEmploy a mix of industry-leading and proprietary AI-driven CADD tools to steer small molecule drug discovery projects across a wide array of targets, including innovative targets with limited chemical precedents.Implement methodologies such as virtual screening, molecular simulation, and ADMET prediction to facilitate critical decision-making during the drug discovery process.Work in tandem with medicinal chemists in molecular design and the formulation of project-specific computational strategies.Serve as an effective liaison among the computational and medicinal chemistry teams, ensuring smooth communication and collaborative decision-making.Thrive in a fast-paced environment that champions innovation and rapid iteration.QualificationsPh.D. in Computational Chemistry, Structural Biology, or a closely related discipline. Candidates with a Ph.D. in organic or medicinal chemistry and substantial laboratory experience transitioning to industry roles in CADD may also be considered.Comprehensive understanding of structure-based drug design and protein-ligand interactions.Expertise in industry-standard CADD software such as MOE, PyMOL, and Schrödinger Suite.A minimum of 5 years of experience as a CADD scientist in the pharmaceutical or biotechnology sector, with direct involvement in active drug discovery projects.While onsite collaboration in our San Diego lab is preferred, we are open to accommodating remote team members.What We OfferCompetitive salary and benefitsComprehensive health care plans, including medical, dental, and vision insurance fully covered for employeesEligibility for stock options

At Genesis Molecular AI, we are creating an elite team of experts in computational chemistry to transform the landscape of drug discovery through advanced machine learning and biophysical simulations. We invite a Senior Computational Aided Drug Discovery (CADD) Scientist to join us in our mission, collaborating closely with scientists in our advanced wet lab and our distributed teams in computational chemistry across the United States.Key ResponsibilitiesEmploy a mix of industry-standard and proprietary AI-driven CADD tools to steer small molecule drug discovery initiatives across a diverse array of targets, including innovative targets with limited chemical history.Utilize techniques such as virtual screening, molecular simulations, and ADMET prediction to facilitate critical decision-making during drug discovery.Work closely with medicinal chemists on molecular design and the creation of tailored computational methodologies for specific projects.Serve as a liaison across teams, effectively bridging communication between our computational and medicinal chemistry departments to ensure smooth information exchange and collaborative strategies.Thrive in a fast-paced environment that encourages innovation and rapid iteration.QualificationsPhD in Computational Chemistry, Structural Biology, or a related discipline. Candidates with a PhD in organic or medicinal chemistry and substantial laboratory experience transitioning into industry roles in CADD are also encouraged to apply.Extensive knowledge of structure-based drug design and protein-ligand interactions.Expertise in using industry-standard CADD tools, including MOE, PyMOL, and Schrodinger Suite.A minimum of 2 years of experience in the pharmaceutical or biotech industry as a CADD scientist, with practical involvement in active drug discovery projects.While onsite presence at our San Diego lab is preferred for collaboration, we are open to considering remote team members as well.What We OfferAttractive SalaryComprehensive Health Care Plans (Medical, Dental, and Vision fully covered for employees)An opportunity to work in a pioneering environment with the latest technologies in drug discovery.

Chemistry InternJoin Genesis Molecular AI, where we are revolutionizing drug design through artificial intelligence to meet critical medical needs. Our cutting-edge laboratory in San Diego invites passionate and proactive individuals to become part of our chemistry team. As a Chemistry Intern, you will gain hands-on experience with laboratory techniques while tackling current chemistry challenges.Your ResponsibilitiesAcquire and apply essential laboratory skills in chemistry.Maintain thorough documentation of all laboratory findings.Participate in project meetings with mentors and effectively communicate your findings.Compile a comprehensive report of your findings at the conclusion of the internship.Perform additional tasks and responsibilities as assigned.Your QualificationsCurrently pursuing a Bachelor’s degree in Organic Chemistry, Biochemistry, Medicinal Chemistry, or a related field.Prior experience in an organic chemistry lab is preferred.Strong organizational, communication, and multitasking skills, with an ability to thrive in a collaborative environment.Demonstrated enthusiasm, integrity, self-motivation, and meticulous attention to detail.

Join Genesis Molecular AI as a Senior / Principal ADME Scientist in San Diego, CA!At Genesis Molecular AI, we are at the forefront of utilizing artificial intelligence to revolutionize rational drug design and tackle significant unmet medical needs. We are looking for an enthusiastic and adaptable ADME Scientist to become a vital part of our Non-Clinical Development team, facilitating the progression of our innovative compounds through both preclinical and clinical phases.This full-time role is set in a dynamic biotech environment where collaboration thrives among a talented team of professionals, all working towards clear scientific objectives. We offer an attractive benefits package, including comprehensive medical and dental insurance, flexible working hours, generous vacation time, and the chance to engage deeply with the inner workings of a biotechnology start-up.The ideal candidate will possess extensive expertise in various ADME-related assays such as metabolic stability, protein binding, drug-drug interactions, and more. They will be skilled in developing, executing, and troubleshooting assays both independently and in collaboration with external partners. As the subject matter expert in in-vitro ADME, you will provide critical strategic input to our project teams. Experience in bioanalytical assays and method development is a plus.

Job Overview: We are seeking a dedicated Bench Scientist II to join our dynamic team in San Diego. This role entails collaborating with fellow scientists to advance translational pharmacology research focusing on various clinical candidate compounds and late-stage assets. Key responsibilities include performing tissue culture, conducting cell-based assays, and executing western blot analysis. The ideal candidate will possess a solid background in cancer biology and relevant laboratory experience while demonstrating strong communication and teamwork skills.Key Responsibilities: Conduct tissue culture, cell-based assays, and western blot analysisWork with unscreened blood, human tissue, or human cell lines

Join Our Team as a Senior / Principal ADME ScientistAt Genesis Molecular AI, we are at the forefront of revolutionizing drug discovery through innovative artificial intelligence-driven approaches. Our San Diego lab is actively seeking a dynamic and skilled Senior / Principal ADME Scientist to enhance our Non-Clinical Development team and propel our compounds through the phases of preclinical and clinical development.This full-time position offers an exciting opportunity to work in a fast-paced biotech environment alongside a collaborative team of experts, all focused on achieving clear scientific and developmental objectives. We provide comprehensive medical and dental benefits, flexible working hours, generous vacation time, and the chance to gain extensive exposure to the inner workings of a biotechnology start-up.The ideal candidate will possess extensive expertise in a range of ADME-related assays, including metabolic stability, protein binding, and drug-drug interactions. You will be instrumental in developing, executing, and troubleshooting assays, as well as managing outsourced work. As a subject matter expert in in-vitro ADME, your strategic input will be crucial to project teams. Experience with bioanalytical assays and method development is highly desirable.