Principal Scientist - Biotransformation

Join our dynamic team at Amgen as a Principal Scientist - Biotransformation in San Francisco. In this pivotal role, you will lead innovative research focusing on biotransformation processes, contributing to the development of cutting-edge therapeutics. Your expertise will drive scientific advancements and support our mission to improve the lives of patients …

Join Databricks as a Principal Data Scientist and contribute to shaping the future of data analytics and machine learning. In this pivotal role, you will leverage your expertise to drive impactful projects, collaborate with cross-functional teams, and lead innovative research initiatives that enhance our product offerings. As a thought leader, you will utilize your extensive knowledge in data science to influence our strategic direction, ensuring our solutions remain at the forefront of technology.

Axon Enterprise develops devices and cloud software aimed at improving safety and justice. Teams value honesty, compassion, and diverse perspectives, working together to make a meaningful impact. The company encourages initiative and personal growth, recognizing the importance of each person’s contribution. Role overview The Principal Data Scientist will join the Office of the Chief Accounting Officer in San Francisco. This position blends technical data science work with strategic collaboration across finance and technology groups. A strong background in finance and accounting is required for success in this role. Main focus Half of the role involves building data analytics tools and pipelines, using AI to speed up large-scale projects such as mergers and acquisitions integration, ERP deployments, data remediation, and SOX compliance. The other half centers on partnering with Controllership, Finance Operations, FP&A, Internal Audit, and Technology to lay the groundwork for AI, automation, and audit readiness. Daily tasks will include using AI-assisted development tools, such as code generation and large language models. Key responsibilities Design and implement data analytics tools, automated validation frameworks, and dashboards to provide Finance Operations and Controllership with real-time insights into data quality across enterprise systems. Use AI to quickly prototype, test, and deploy these solutions. Collaborate with source-system owners in Revenue Operations, Procurement, Human Resources, and Engineering to address data issues at their source and improve upstream data integrity. Maintain data dictionaries, lineage documentation, and quality scorecards for core controllership data assets. Set and enforce standards for master data management (MDM). Work with the Chief Information Officer and IT to develop integration strategies that enable seamless data flow.

About GustoAt Gusto, we are dedicated to empowering small businesses to flourish. Our comprehensive solutions encompass payroll, health insurance, 401(k)s, and HR, allowing business owners to concentrate on what they do best: serving their customers and mastering their craft. With teams located in Denver, San Francisco, and New York, we proudly support over 400,000 small businesses nationwide, while striving to cultivate a workplace that reflects and honors our diverse clientele. Discover more about our Total Rewards philosophy.About the Role:We are seeking an experienced and driven Principal Data Scientist with over 10 years of expertise to join our Product team. In this pivotal role, you will utilize your skills in experimentation, statistical inference, and causal analysis to influence strategic decision-making that propels our organizational success. The ideal candidate is a compelling data storyteller with robust statistical and programming capabilities, passionate about leveraging data to support small business growth.In this position, you will collaborate closely with our Product, Engineering, Design, Finance, and other Data teams to become an authority on your domain's data, establish and monitor key metrics to assess business performance, and analyze our Payroll, Benefits, and HR data to extract actionable insights. Additionally, you will adopt AI-assisted methodologies to enhance analysis efficiency, improve rigor, and broaden the dissemination of insights across Gusto.We have multiple senior Data Scientist roles available at this senior level, each concentrating on various critical business areas.Here’s what you’ll do day-to-day:Strategic Leadership: Develop the analytical strategy for a significant product or business segment. Pinpoint high-impact opportunities, set long-term objectives for measurement and experimentation, and synchronize executive stakeholders on data-driven initiatives.Execution Excellence: Drive the implementation of comprehensive analytical roadmaps that influence company strategy. Ensure alignment and uphold consistent analytical rigor and metric integrity across product domains.Scaled Impact: Beyond being an expert in statistical methods and fostering impact...

About Marathon FusionAt Marathon Fusion, we are pioneering the engineering technologies essential for transitioning fusion from experimental stages to operational power plants. While many in the industry concentrate on developing new fusion devices, we are dedicated to creating practical systems that facilitate the deployment of fusion energy at a scale relevant to combat climate change.Our focus includes the development of critical fuel cycle technologies and plant-level systems that support stable isotope production, fuel cycle closure, and advanced blanket systems aimed at enabling both energy generation and the production of valuable co-products.Established in 2023, Marathon Fusion is committed to constructing the components and systems that will render fusion a practical, abundant, and reliable energy source for the 21st century.Culture at Marathon FusionWe cultivate a startup environment that demands focus, adaptability, and prioritization in a rapidly evolving landscape. Success in this setting requires exemplary proactive communication across various roles and backgrounds, the ability to foster and maintain trust among team members, and a commitment to continuous learning and skill development. We emphasize the importance of self-direction in each team member.

Role overview The Principal Research Scientist – Scaling at Databricks leads research projects that advance how the company’s data analytics platform handles large workloads. This San Francisco-based role focuses on designing and improving algorithms that enable efficient large-scale data processing and machine learning. Collaboration is central, with regular work alongside engineering, product, and research teams. What you will do Lead research to develop algorithms that scale for data analytics applications. Work with colleagues across engineering, product, and research to strengthen machine learning capabilities. Use deep expertise to shape the direction and architecture of the Databricks platform. Drive new ideas and solutions that influence the future of data science and analytics at Databricks. Location This role is based in San Francisco, California.

Join AbbVie as a Principal Research Scientist I in our Biologics Screening team within Discovery Biotherapeutics. In this pivotal role, you will lead cutting-edge research initiatives focused on biologics screening methodologies that drive our biotherapeutic development pipeline. You will collaborate with a multidisciplinary team of scientists to innovate and optimize screening strategies, ensuring the identification of high-potential therapeutic candidates.

About GustoAt Gusto, we are dedicated to empowering the small business economy. We take care of complex tasks such as payroll, health insurance, 401(k)s, and HR, allowing business owners to focus on their passions and their customers. With vibrant teams across Denver, San Francisco, and New York, we proudly support over 400,000 small businesses nationwide. We are committed to creating a workplace that reflects and celebrates the diversity of our customer base. Discover more about our Total Rewards philosophy.As a Principal Data Scientist on the Payments team, you will play a crucial role at the intersection of financial systems and data science. You will transform the complexities of a large-scale payments ecosystem into actionable insights and models that drive the development, operation, and enhancement of our payment solutions.Your responsibilities will include collaborating closely with Product, Engineering, Design, Finance, and other Data teams. You will gain expertise in your domain's data, define metrics to assess our business performance, and analyze payments data to provide valuable insights. Additionally, you will integrate AI-assisted methodologies to expedite analysis, improve analytical rigor, and broaden the dissemination of insights across Gusto.This position is ideal for individuals who are equally adept at analyzing ledger-level transaction data and engaging with payments engineering teams to impact architectural decisions. If you are passionate about enhancing the financial well-being of countless small businesses, this opportunity is for you.

Okta secures digital identity for both AI and human users, building infrastructure that helps organizations adapt to new challenges. The company focuses on solving complex problems that have a real impact for its customers. The Pricing Strategy team partners with Product, Finance, Sales, and Operations to define how Okta packages, prices, and monetizes its products worldwide. This group blends strategy with analytics, using market trends and customer data to develop recommendations that influence executive decisions and field execution. Role overview The Principal Data Scientist, Pricing Strategy, reports to the Head of Pricing Strategy. This position leads analytics projects that shape pricing and packaging strategies across Okta’s product portfolio. The role combines quantitative analysis with strategic thinking, developing measurement methods, building and deploying models, and running test-and-learn programs to guide monetization. Collaboration with senior leaders in Product and Go-to-Market teams is essential, turning open-ended questions into actionable insights and scalable plans. What you will do Strategic Pricing Influence: Work with Product, Go-to-Market, and Finance leaders to shape pricing, packaging, and discount strategies using data-driven insights. Advanced Analytics and Modeling: Build and apply models and analytical frameworks to forecast pricing effects, predict customer behavior, and estimate revenue outcomes across regions and segments. Experimentation and Pilots: Design and evaluate pilots and test-and-learn initiatives for new pricing strategies, including defining success metrics and evaluation methods. Deep-Dive Insight Generation: Analyze large, complex datasets to uncover drivers of purchasing, discounting, retention, and monetization performance. Metrics and Dashboards: Develop dashboards and reports that clearly communicate findings to stakeholders. Location This position is based in Bellevue, Washington or San Francisco, California.

Our MissionAt Altos Labs, we are dedicated to restoring cell health and resilience through advanced cell rejuvenation techniques aimed at reversing diseases, injuries, and age-related disabilities.For more information, please visit our website at altoslabs.com.Our ValueWe embrace a singular value at Altos: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe recognize that diverse perspectives are vital to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders collaborate from around the globe, united by a common mission. Our commitment to fostering a sense of belonging ensures that every employee feels valued for their unique insights. We all share the responsibility of maintaining a diverse and inclusive workplace.What You Will Contribute To AltosAs a Senior or Principal Machine Learning Scientist, you will be pivotal in developing groundbreaking generative AI/ML models that address multi-modal, multiscale biological challenges—from virtual cell simulations to agentic target assessments. We seek an innovative, hands-on individual who thrives in a collaborative and fast-paced environment, emphasizing teamwork, transparency, scientific excellence, originality, rigor, and integrity.

Join Tendo as a Principal Data Scientist and contribute to our analytics projects aimed at enhancing quality management and risk adjustment in healthcare. In this pivotal role, you will harness data from diverse public and private sources, transforming it into actionable insights for health systems. Your expertise will drive the development, maintenance, and enhancement of predictive models that elevate our products across various domains, including quality, risk, and operational efficiency. We seek an individual with an AI-native mindset, possessing hands-on experience in applying AI or machine learning to tackle real-world challenges. If you are passionate about leveraging emerging AI technologies to improve healthcare delivery and outcomes, this is the opportunity for you. Additionally, you will have the chance to pose innovative, data-driven questions and spearhead new analyses.

Join Merge Labs, a pioneering research facility dedicated to merging biological and artificial intelligence to enhance human capabilities, agency, and experience. We aim to achieve this by crafting innovative brain-computer interfaces that communicate with the brain at high bandwidth, seamlessly integrate with cutting-edge AI, and prioritize safety and accessibility for all users.About the Team:At Merge Labs, we are on a mission to revolutionize brain-computer interfaces by leveraging advancements in synthetic biology, neuroscience, AI, and non-invasive imaging technologies. Our cross-functional data science team is situated at the convergence of computational modeling, neuroscience, and biomolecular engineering. This collaborative unit works closely with wet-lab scientists, automation specialists, and data engineers to develop machine learning frameworks that facilitate rapid molecule discovery and device enhancement.About the Role:We are seeking a talented Senior / Principal ML Scientist to architect and scale Bayesian optimization and reinforcement learning frameworks that guide molecular engineering initiatives through iterative design-build-test-learn (DBTL) cycles. You will start with a fresh approach to construct the company's closed-loop optimization infrastructure, establishing the data and modeling foundations that link experiments with these ML frameworks. Over time, you will transition prototypes into operational pipelines, significantly enhancing experimental throughput and discovery success across various biomolecular and neuroengineering sectors.Key Responsibilities:Develop the scientific and engineering framework for active learning and closed-loop optimization, encompassing data ingestion, ML modeling, and library design.Collaborate with wet-lab scientists to establish feasible optimization objectives while incorporating domain-specific priors and constraints.Create prototypes for representation learning and acquisition strategies utilizing both internal and public datasets; benchmark and validate the performance of models.Integrate machine learning models with experimental data streams, making them accessible to non-domain experts for broader utilization.Extend machine learning frameworks to accommodate multi-objective or constrained optimization challenges.Stay abreast of the latest advancements in Bayesian optimization, active learning, and reinforcement learning, and prototype innovative algorithms to enhance the company's capabilities.

Role overview This Senior or Principal Scientist position at Lila Sciences centers on developing foundation models for life sciences. The role is based in San Francisco, CA. What you will do Lead the design and creation of advanced machine learning models for applications in life sciences. Direct research projects that drive new product development in healthcare and biotechnology. Use expertise in foundation models to address complex challenges within the life sciences field. Impact This role operates at the intersection of machine learning and life sciences, supporting research and products aimed at improving healthcare solutions.

Our MissionAt Altos Labs, we are dedicated to revitalizing cell health and resilience through innovative cell rejuvenation techniques to reverse disease, injury, and the disabilities that arise throughout life.Discover more about our vision at altoslabs.com.Our ValuesOur core value is simple yet powerful: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe understand that diverse perspectives are crucial for scientific breakthroughs and exploration. At Altos, exceptional scientists and industry leaders collaborate from around the globe to drive our shared mission forward. We prioritize a culture of belonging, ensuring that every employee feels valued for their unique contributions. We are all responsible for maintaining a diverse and inclusive workplace.Your Contributions to AltosJoin Altos Labs in creating a premier AI ecosystem aimed at addressing the most intricate challenges in human biology. You will be instrumental in designing and developing high-performance, scalable solutions that integrate high-dimensional biomedical imaging with molecular and linguistic data.Your role will involve implementing large-scale multimodal data fusion, advancing beyond basic image analysis to develop predictive models that span various biological domains. You will engage directly with data and coding, partnering with our engineering team to ensure these models are scalable, efficiently trainable in distributed cloud environments, and accessible to our global research network.Key ResponsibilitiesModel Development: Create, implement, and train large-scale foundational models (e.g., Vision Transformers, Multimodal LLMs) capable of embedding spatial data and integrating diverse modalities.Innovative Data Fusion: Apply cutting-edge cross-domain mapping and fusion techniques to align heterogeneous biological datasets.Scaling & Training: Develop and oversee high-performance ML pipelines designed to handle petabyte-scale image collections and multi-omics data streams in a cloud infrastructure.Technical Collaboration: Work closely with experimental scientists and software engineers to convert biological complexity into high-performance code and reliable distributed systems.Who You AreWe seek a technical expert who excels at unraveling "unsolvable" challenges through programming and meticulous experimentation. We welcome candidates at the Scientist I, Scientist II, or Senior Scientist levels.

Join the dynamic Analytics team at DoorDash as a Data Scientist or Senior Data Scientist, where your expertise will directly influence strategic decisions and operational improvements. You will uncover valuable insights from vast datasets, transforming them into actionable recommendations that drive company-wide initiatives. Collaborate with diverse teams in areas like Consumer & Growth, Business Operations, and Customer Experience to elevate our analytics capabilities and impact our business in meaningful ways.

Merge Labs is an innovative research facility dedicated to merging biological sciences and artificial intelligence to enhance human capability, autonomy, and experience. Our mission is to pioneer revolutionary methodologies in brain-computer interfaces that facilitate high-bandwidth interactions with the brain, seamlessly integrate advanced AI, and maintain safety and accessibility for all users.About the TeamAt Merge, we are addressing some of the most ambitious challenges in molecular engineering, synthetic biology, and neuroscience. Our Research Platform Team is responsible for creating the experimental frameworks necessary to tackle these challenges with exceptional speed and precision. The tools and methodologies developed by our team significantly enhance molecular assembly, protein expression, mammalian cell culture, advanced microscopy, sequencing, and unique custom techniques. We collaborate with program teams to establish and optimize these capabilities, implement automation where beneficial, and integrate with our data science and machine learning pipelines, continuously pushing the boundaries of throughput and innovation.About the RoleAs a Platform Scientist, you will be instrumental in developing high-efficiency and high-throughput experimental pipelines that accelerate research initiatives. You will work closely with program leads, project scientists, data scientists, and engineers, leading your work and potentially recruiting additional team members as necessary.Key Responsibilities:Collaborate with program leads and scientists to identify critical experimental requirements and workflows.Develop processes to facilitate high-throughput and/or high-efficiency experiments, including reagent production and analysis.Scope, procure, construct, program, and validate instruments to support experimental workflows.Ensure the quality, reliability, and integrity of data generated from automated pipelines, including defining and implementing suitable quality control checkpoints.Work alongside data science and machine learning engineers to incorporate metadata tracking, computational design, and analysis into experimental pipelines.Partner with electrical, mechanical, and software engineers to create custom setups.Innovate and validate concepts to enhance experimental throughput.

Join HeartFlow, Inc. as a Staff Data Scientist and play a crucial role in revolutionizing cardiovascular care through advanced data analytics. You will leverage your expertise in data science to develop innovative algorithms and models that will enhance our medical imaging solutions, ultimately improving patient outcomes. Collaborate with a dynamic team of professionals who are dedicated to delivering exceptional healthcare solutions.

As a Bench Scientist I at Integrated Resources, Inc., you will engage in pivotal laboratory activities that drive innovative solutions in the scientific field. This role is an excellent opportunity for emerging scientists eager to apply their academic knowledge in a practical setting, contributing to research and development projects.

Join ASM – Where Innovation Meets Collaboration!With over 55 years of pioneering technology, ASM stands at the forefront of innovation, shaping the future of advanced semiconductor devices. Our diverse team of more than 4,500 professionals from 70 nationalities drives advancements in key trends such as 5G, cloud computing, AI, and autonomous driving. We pride ourselves on our commitment to diversity, inclusion, and sustainability, striving to make a positive impact on the world. Our comprehensive development programs are designed to foster your growth, enabling you to push the boundaries of innovation. Position: Senior Principal Engineer, Systems (Plasma & Multi-Scale Simulation Scientist)The Simulation and Modeling Hub is looking for a Senior Plasma & Multi-Scale Simulation Scientist to enhance our plasma modeling capabilities. This pivotal role involves integrating plasma physics, surface chemistry, and feature-scale behavior to develop predictive, physics-based simulation workflows that support advanced semiconductor processes including PEALD, PECVD, ALE, and RIE.

We are seeking a highly motivated and talented Senior Associate Scientist to join our dynamic team in San Francisco. In this role, you will collaborate with cross-functional teams to advance our scientific initiatives and contribute to groundbreaking research. You will have the opportunity to work with cutting-edge technologies and methodologies, driving innovation within our organization.