Senior Scientist in Medicinal Chemistry

At Olema Oncology, we are unwavering in our commitment to advancing innovative treatments for breast cancer and beyond. Our flagship candidate, palazestrant (OP-1250), is a groundbreaking complete estrogen receptor antagonist (CERAN) currently being developed for metastatic breast cancer. With the potential to be a market leader, it is designed for use both …

Charter:Join us as a pioneering member of our team dedicated to revolutionizing the field of toxicity testing through the development of precise AI systems that replace traditional lab and animal experiments.What We Seek:We are on the lookout for extraordinary individuals who not only inspire us but also challenge us to elevate our performance. Ideal candidates will infuse the team with energy and a sense of purpose, demonstrating a keen understanding of what truly matters. A sense of urgency, proactive problem-solving skills, and an insatiable curiosity about all aspects of Axiom are essential. We value technical excellence and a deep commitment to one's craft. Those who are driven by the thrill of tackling complex scientific challenges will find a rewarding environment here, as we strive to build a transformative company together.Your Responsibilities:Lead the creation of AI models to predict human clinical outcomes, analyzing performance to identify both successful and less effective applications.Work alongside machine learning researchers to develop advanced models for human clinical predictions.Oversee model usage, ensuring clarity, refinement, and continual enhancement.Clean, curate, and process extensive chemistry datasets encompassing a variety of unique compounds for model evaluation and training.Collaborate with leading drug hunters at Pfizer, Takeda, Gilead, Merck, and others to interpret model predictions and streamline decision-making processes.Devise innovative strategies to intelligently expand our experimental and molecular datasets, guided by data insights, ML performance, and real-world applications.Influence ongoing drug programs and contribute to reshaping the methodologies of top pharmaceutical teams in developing safe and effective medications.Help refine Axiom’s product offerings based on customer feedback and insights gained through engagement with leading drug hunters.Desired Expertise:Possession of an advanced degree in chemistry, cheminformatics, or computational chemistry, or relevant industry experience in drug discovery.

At Olema Oncology, we are committed to pioneering innovative treatments for breast cancer and beyond. Our leading program, palazestrant (OP-1250), acts as a complete estrogen receptor antagonist (CERAN) and is currently being developed for the treatment of metastatic breast cancer, showing substantial promise both as a standalone therapy and in combination with other treatments for ER+/HER2- metastatic breast cancer. Additionally, our upcoming candidate, OP-3136, is a KAT6 inhibitor with the potential to lead the market.Our scientific innovations are propelled by a culture of fearless support, motivation, and constructive challenge among our team members. At Olema, we believe that prioritizing our people results in unparalleled achievements. If you are eager to be part of a transformative journey that makes a significant impact on our patients, your career, and beyond, we invite you to join us.You can view our latest corporate presentations here.As a Synthetic Medicinal Chemistry Intern, reporting to the Principal Research Associate, you will engage in hands-on organic chemistry laboratory work within a dynamic biotechnology setting, collaborating closely with our Medicinal Chemistry team. This internship offers a valuable chance to conduct organic chemistry experiments aimed at synthesizing compounds for biological assays, directly contributing to our ongoing research initiatives.This is a 10-week paid summer internship, offering a rate of $22/hour for a 40-hour work week at our San Francisco facility. The internship will commence on June 8 and conclude on August 14.Please note that applicants must have authorization to work for any employer in the U.S., as we are currently unable to sponsor or take over sponsorship of an employment visa.Your scope of work will primarily include:

Inductive Bio is a pioneering AI medicinal chemistry partner dedicated to revolutionizing drug discovery. We create innovative virtual labs that empower drug discovery teams to make informed decisions more efficiently throughout the entire DMTA cycle. Our advanced platform features Beacon-1 ADMET prediction models, human dose projection tools, and Indy, an AI-driven medicinal chemistry assistant. In collaboration with Enamine, we provide library synthesis and direct-to-dose testing, seamlessly bridging the gap between computational design and experimental validation. Together, we fuel numerous small molecule and beyond-rule-of-five initiatives for our biotech and pharmaceutical partners.Beacon-1 has consistently excelled, securing 1st place in both the 2025 Polaris and 2026 OpenADMET-ExpansionRx blind competitions, surpassing industry giants like Merck & Co and NVIDIA, as well as EMD Serono. Our efforts have garnered $30M in funding from notable investors such as Obvious Ventures, a16z Bio + Health, and Lux Capital, in addition to being awarded $21M from the ARPA-H CATALYST program to advance next-generation toxicity models.The RoleWe are in search of an experienced computational or medicinal chemist to join our dynamic Product Science team as a Product Scientist. In this pivotal role, you will be the primary scientific liaison for partner projects, leveraging your expertise in medicinal chemistry, computational chemistry, and DMPK to tackle complex molecular optimization challenges with an emphasis on dose-centric solutions. You will engage with a diverse array of small molecule modalities, therapeutic areas, and modeling obstacles.As a thought leader in the evolution of Inductive's platform, you will contribute to the enhancement of our predictive models and dose projection tools, as well as Indy, our AI medicinal chemistry assistant, drawing from your own experiences and insights gained from real-world partner programs. We seek an individual whose instincts regarding small molecule optimization are honed through extensive hands-on experience, and who is eager to utilize these instincts to shape products that empower drug discovery teams.Your Responsibilities:Partner-Facing ScienceCultivate and manage the scientific relationships with partner project teams across various modalities, including reversible and covalent small molecules, macrocycles, molecular glues, and heterobifunctionals.Organize and clarify complex program data. Analyze structure-activity relationships (SAR), discern the insights provided by the data, and proactively address inconsistencies before they lead to detrimental decisions.Steer medicinal chemistry strategies: determine what to synthesize, what to test, how to prioritize compounds for further development, and where to allocate synthetic resources. Identify potential liabilities early in the process and assist partners in constructing risk mitigation plans.

Our MissionAt Altos Labs, we are dedicated to revitalizing cell health and resilience through innovative cell rejuvenation techniques to reverse disease, injury, and the disabilities that arise throughout life.Discover more about our vision at altoslabs.com.Our ValuesOur core value is simple yet powerful: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe understand that diverse perspectives are crucial for scientific breakthroughs and exploration. At Altos, exceptional scientists and industry leaders collaborate from around the globe to drive our shared mission forward. We prioritize a culture of belonging, ensuring that every employee feels valued for their unique contributions. We are all responsible for maintaining a diverse and inclusive workplace.Your Contributions to AltosJoin Altos Labs in creating a premier AI ecosystem aimed at addressing the most intricate challenges in human biology. You will be instrumental in designing and developing high-performance, scalable solutions that integrate high-dimensional biomedical imaging with molecular and linguistic data.Your role will involve implementing large-scale multimodal data fusion, advancing beyond basic image analysis to develop predictive models that span various biological domains. You will engage directly with data and coding, partnering with our engineering team to ensure these models are scalable, efficiently trainable in distributed cloud environments, and accessible to our global research network.Key ResponsibilitiesModel Development: Create, implement, and train large-scale foundational models (e.g., Vision Transformers, Multimodal LLMs) capable of embedding spatial data and integrating diverse modalities.Innovative Data Fusion: Apply cutting-edge cross-domain mapping and fusion techniques to align heterogeneous biological datasets.Scaling & Training: Develop and oversee high-performance ML pipelines designed to handle petabyte-scale image collections and multi-omics data streams in a cloud infrastructure.Technical Collaboration: Work closely with experimental scientists and software engineers to convert biological complexity into high-performance code and reliable distributed systems.Who You AreWe seek a technical expert who excels at unraveling "unsolvable" challenges through programming and meticulous experimentation. We welcome candidates at the Scientist I, Scientist II, or Senior Scientist levels.

Join the dynamic Analytics team at DoorDash as a Data Scientist or Senior Data Scientist, where your expertise will directly influence strategic decisions and operational improvements. You will uncover valuable insights from vast datasets, transforming them into actionable recommendations that drive company-wide initiatives. Collaborate with diverse teams in areas like Consumer & Growth, Business Operations, and Customer Experience to elevate our analytics capabilities and impact our business in meaningful ways.

Join General Medicine as a Mobile Engineer!At General Medicine, we are on a mission to revolutionize healthcare access. As a Mobile Engineer, you will play a pivotal role in developing and scaling our innovative healthcare store, simplifying the process of obtaining care. Our platform provides upfront pricing for virtual and in-person visits, prescriptions, labs, imaging, and more, making healthcare more transparent and accessible.Your Role:We are seeking a skilled Mobile Engineer to spearhead the creation of our inaugural native mobile application using React Native. This is a foundational position where you will take the lead in building the app from the ground up, making essential architectural decisions, and establishing frameworks that the rest of our team will utilize.Ideal Candidate:Our ideal candidate has a proven track record of shipping and maintaining React Native applications in a production environment. You should have a strong grasp of the distinctions between React Native and native iOS/Android development. Proficiency in Swift or Kotlin is essential for tasks such as HealthKit integrations, push notifications, or video calling SDKs. While your primary focus will be on TypeScript and React, you should also be open to contributing to our Next.js web frontend, as we view mobile and web as a unified experience.We value technical excellence and are looking for someone who can navigate the balance between speed and quality. Our engineers are proactive, versatile, and often engage in writing product requirements, analyzing SQL data for feature performance, and taking ownership of quality assurance. No task is too small if it contributes to delivering an exceptional product. If you thrive in ambiguous environments and are eager to collaborate closely with design, operations, and clinical teams, we want to hear from you!You don't need a healthcare background, but enthusiasm for tackling the complexities of the American healthcare system, including EHR integration and revenue cycle management, is a plus.

We are seeking a highly motivated and talented Senior Associate Scientist to join our dynamic team in San Francisco. In this role, you will collaborate with cross-functional teams to advance our scientific initiatives and contribute to groundbreaking research. You will have the opportunity to work with cutting-edge technologies and methodologies, driving innovation within our organization.

About Genesis Molecular AIGenesis Molecular AI integrates advanced molecular machine learning with fundamental physics to uncover innovative small molecule therapies for critical diseases. Our state-of-the-art molecular AI platform, GEMS, employs generative models alongside high-throughput molecular simulations to efficiently explore chemical space and prioritize compounds with unmatched precision and speed.About Our TeamWe have assembled a premier computational team that collaborates with machine learning researchers, medicinal chemists, and biologists to transform our computational models into viable drug candidates for both our internal pipeline and pharmaceutical partners.You will be a part of a team guided by seasoned drug discovery experts and method developers specializing in statistical mechanics, free energy methods, and computer-aided drug design.About the RoleWe are seeking a binding free energy expert who possesses a robust understanding of the theoretical aspects necessary for proposing new methodologies, as well as the coding skills required to implement them. This role involves advancing free energy methods within our platform and overseeing their application.You will serve as a critical resource for our teams in need of physics-based evaluations of tightly binding compounds, particularly in potency ranges where existing models may falter. Your contributions will directly influence our compound selections, the progression of potential candidates, and the speed at which we identify optimal molecules for patient care.This position requires active engagement—an individual who enjoys the intricacies of coding and tool development to empower project teams.Responsibilities:Oversee the binding free energy function:Manage small molecule binding free energy calculations that inform project decision-making.Establish and refine best practice protocols across various programs, adapting them as the platform evolves.Optimize and advance existing methodologies:Build upon current methods and code bases, including Free Energy Perturbation (FEP), Thermodynamic Integration (TI), and related alchemical/free energy workflows.

At Descript, we are on a mission to revolutionize the way audio and video content is created. Our innovative platform has earned the trust of renowned podcasters, influencers, and prestigious organizations like BBC, ESPN, HubSpot, Shopify, and The Washington Post. With $100M in funding from top investors, including the OpenAI Startup Fund, Andreessen Horowitz, Redpoint Ventures, and Spark Capital, we are poised for tremendous growth. We are seeking a proactive and analytical Senior Marketing Data Scientist to join our dynamic Growth team. In this role, you will collaborate with the Performance Marketing team to design and implement a comprehensive measurement framework, optimize marketing performance across the entire funnel, and drive data-informed business strategies. This crucial position will enable Descript to enhance its marketing capabilities across both B2C and B2B sectors. You will leverage AI-driven analytics tools to streamline decision-making processes and deliver scalable predictive insights. This position can be performed remotely within the United States or onsite in the San Francisco Bay Area.

About the Role Grow Therapy is hiring a Senior or Staff Data Scientist in San Francisco. This role focuses on using data to inform key decisions and improve therapy services.

At Real Chemistry, our mission is to enhance global health through our unwavering commitment to innovation and excellence. Our unique blend of scientific expertise, creative intuition, and cutting-edge AI insights creates an environment where transformative healthcare solutions flourish. As a leading global agency, we deliver a comprehensive range of healthcare communications and marketing services to our esteemed clients, including prominent pharmaceutical and biotech firms.Our culture, encapsulated in #LifeatRealChem, is centered around collaboration and shared success. We believe in the power of teamwork and are dedicated to achieving excellence for both our clients and colleagues. Whether you're an experienced professional or just embarking on your career journey, if you share our passion for healthcare and connection, we encourage you to explore our exciting opportunities.Discover your purpose. Embrace innovation. Experience #LifeatRealChem.We are seeking a dynamic Senior Account Executive to become a vital part of our expanding team!21GRAMS, a division of Real Chemistry, embraces an innovative advertising approach, aiming to make healthcare more human-centric through our work, client relationships, and internal culture. We foster an environment where everyone is encouraged to support one another while holding high standards for our work. If you’re motivated by more than just a paycheck and want to impact the world, we want to hear from you!This is a hybrid position, with the option to work from any of our US offices—including New York City, Boston, Chicago, Carmel, Lambertville, or San Francisco—or remotely from anywhere in the US, depending on business needs.

Join our innovative team at Pinterest as a Senior Data Scientist in the Core division. We're looking for a data-driven professional who is passionate about leveraging data analytics and machine learning to enhance user experience and drive business outcomes. At Pinterest, you will collaborate with cross-functional teams to develop data models and insights that influence strategic decisions.

Join Our Team at AlembicAlembic is at the forefront of solving one of marketing's biggest challenges: demonstrating what truly works. If you are seeking a dynamic and fast-paced B2B platform where you can contribute to the success of leading enterprises such as NVIDIA and Delta, this is your opportunity.We are unraveling the complexities of modern marketing. At Alembic, you will help build trusted systems that Fortune 100 companies rely on to make multimillion-dollar decisions. Our team is supported by prominent technology leaders, including WndrCo (founded by DreamWorks founder Jeffrey Katzenberg), Jensen Huang, Joe Montana, and many others.The Position - Senior Field ScientistWe are looking for a Senior Field Scientist to spearhead research initiatives that validate the efficacy of our data, cloud, and AI solutions for marketers. In this role, you will design and implement field studies using customer data, apply rigorous analytical methods, and present research results that support transformative marketing insights. As a senior team member, you will also guide and mentor junior field scientists while advancing our research methodologies. This position is based in San Francisco (Onsite).Your ResponsibilitiesResearch & Analysis:Design and conduct complex field studies to test hypotheses regarding marketing effectiveness, substantiating Alembic's revolutionary value.Lead data collection efforts and requirements gathering with senior customer stakeholders, treating each engagement as a scientific inquiry.Utilize rigorous analytical methodologies to process customer data, ensuring scientific integrity for enterprise-scale research projects.Formulate and test hypotheses about marketing performance, employing experimental design principles during customer interactions.Research Communication & Collaboration:Deliver engaging presentations of research findings to C-level and senior customer stakeholders, translating complex analytical insights into actionable business implications.Collaborate with Enterprise Account Executives and Product teams to synchronize research methodologies with strategic objectives and ensure scientific rigor supports the sales cycle.Establish scalable research processes and best practices within the field science team.Mentor and develop junior field scientists in effective experimental design and analytical techniques.

About tvScientifictvScientific is the premier CTV advertising platform specifically designed for performance marketers. By harnessing extensive data and innovative science, we automate and enhance TV advertising to achieve tangible business results. Our integrated solution encompasses media buying, optimization, measurement, and attribution, all within a single, efficient platform. Developed by industry veterans with deep experience in programmatic advertising, digital media, and ad verification, our platform provides advertisers with the trust they need to scale their business.As a vital member of our Data Science team, you will transform data into actionable insights, influence business strategies, and lead analytics projects from start to finish. Your daily responsibilities will include crafting tailored reporting and analytics tools to address the specific needs of our clients.

Altos Labs focuses on revitalizing cellular health and resilience to address disease, injury, and lifelong disabilities. The company emphasizes collaboration and inclusion, aiming to value every perspective within its team. Altos Labs has received recognition among leading biotech companies and is featured in Forbes 2026 Best Startups in America. Role overview The Senior Scientist, Discovery Pharmacology, will join the Drug Discovery and Development (3DS) division in the San Francisco Bay Area. This laboratory-based role centers on developing and executing cell-based and biochemical assays, along with complex in vitro models, to support drug discovery in rejuvenation biology and novel therapies. What you will do Investigate and validate drug targets, defining mechanisms of action through various pharmacological methods. Design, automate, and troubleshoot assays to advance discovery objectives. Analyze experimental data and present findings to guide project strategy. Maintain thorough records using an electronic lab notebook (ELN) for reproducibility and data integrity. Collaborate with cross-functional teams, including Product Development. Learn more about Altos Labs at altoslabs.com.

Our VisionSince its inception in 2012, Tinder® has transformed the way individuals connect, soaring from a mere 1 match to an astounding one billion matches within just two years. This remarkable growth underscores our dedication to nurturing authentic human connections. To date, the app has been downloaded over 630 million times, facilitating more than 97 billion matches and catering to approximately 50 million users monthly across 190 countries and in over 45 languages—an unparalleled reach in the industry. In 2024, Tinder proudly received four Effie Awards for its inaugural global brand campaign, “It Starts with a Swipe”™.Our Core ValuesUnified PurposeWe collaborate closely to enhance the Tinder experience for our users. Our success is a collective effort that thrives on cross-functional teamwork, creativity, and a shared vision.Take InitiativeWe embrace accountability and strive to drive positive change through ownership, innovation, and a relentless commitment to excellence.Continuous GrowthWe foster an environment where risk-taking is encouraged. We value open dialogue, constructive feedback, and learning from our experiences to foster ongoing improvement.Innovative Problem SolvingWe prioritize finding solutions when facing challenges, maintaining agility, and focusing on how to move forward rather than fixating on past obstacles.Celebrate DiversityWe are committed to creating a workplace that reflects the diverse backgrounds of our user base. By embracing varied perspectives, we enhance the experiences we create for both our users and our team.As the Product Team Lead (PTL) for Chemistry, Tinder's innovative AI matchmaking feature, you will spearhead the strategy, roadmap, and implementation of one of our key AI-driven initiatives. Your role will be pivotal in shaping the future of online dating by enhancing match quality and real-world results. Collaborating across product, design, machine learning, trust & safety, and growth teams, you will leverage cutting-edge recommendation systems and large language models (LLMs) to ensure users enjoy meaningful connections.

About AirwallexAirwallex stands as the premier unified payments and financial platform tailored for global enterprises. Our unique blend of proprietary infrastructure and advanced software empowers over 200,000 businesses across the globe, including notable names such as Brex, Rippling, Navan, Qantas, and SHEIN. We offer fully integrated solutions for managing everything from business accounts and payments to spend management, treasury services, and embedded finance on a global scale.Founded in Melbourne with a dynamic workforce of over 2,000 innovative professionals across 26 global offices, Airwallex is valued at $8 billion. We are backed by leading investors such as T. Rowe Price, Visa, Mastercard, Robinhood Ventures, Sequoia, Salesforce Ventures, DST Global, and Lone Pine Capital, positioning us at the forefront of creating the future of global payments and financial services. If you are ready to embark on the most ambitious journey of your career, we invite you to join us.Attributes We ValueWe seek builders with an entrepreneurial spirit who aspire for real impact, accelerated growth, and genuine ownership. You bring deep expertise and analytical thinking, driven by our mission and operating principles. You thrive in a fast-paced environment, demonstrating curiosity and making decisions based on foundational principles while balancing speed with thoroughness.With a humble and collaborative approach, you transform innovative ideas into tangible products and ensure projects are completed from start to finish. Leveraging AI, you work efficiently and solve problems quickly. Here, you will tackle complex, high-impact challenges alongside exceptional teammates and advance your career as we redefine the future of global banking. If this resonates with you, let's innovate together.Growth Data Science TeamThe Growth Data Science team is at the heart of Airwallex’s growth strategy, leveraging data and AI to create a sustainable competitive edge. We design and implement advanced solutions encompassing predictive modeling, personalization, LLM-powered systems, incentive optimization, and causal inference to drive significant growth throughout the customer journey.Discover more about our data science team in this blog.The RoleWe are on the lookout for a Senior Data Scientist to collaborate closely with our Growth and Marketing teams. Your role will involve designing, deploying, and refining impactful data science initiatives that drive our growth objectives.

Join SoFi as a Senior Data Scientist in our Credit Strategy team, where you will leverage data-driven insights to enhance our lending strategies and improve customer experiences. You will be responsible for developing advanced analytical models, utilizing machine learning techniques, and collaborating with cross-functional teams to drive data-centric decisions.

Join Aircall, the leading integrated customer communications and intelligence platform that empowers growing businesses worldwide. With a trusted network of over 20,000 companies, Aircall seamlessly integrates voice and digital channels into one powerful platform, featuring one-click connections with top CRMs and over 100 essential business tools. Our AI-driven insights and automation capabilities enable sales and support teams to optimize their time, discover new opportunities, and deliver outstanding customer experiences. With a diverse global team of over 600 in cities such as Paris, New York, San Francisco, and more, Aircall is revolutionizing the way businesses engage with their customers, fostering deeper relationships and driving measurable success.Our Work Culture: At Aircall, we prioritize customer satisfaction, continuous learning, and extraordinary results. We encourage open collaboration, ownership, and swift, informed decision-making. If you thrive in a dynamic, team-oriented environment where curiosity, trust, and impact are key, you will fit right in.About Our TeamThe Data team at Aircall is integral to our decision-making process, driving innovation and growth through advanced data solutions, tools, and actionable insights.Role OverviewAs a Senior Data Scientist, you will play a crucial role in providing insights to our product and business teams, collaborating closely with product and engineering leaders. You will support key initiatives such as pricing strategies, packaging, multi-product approaches, and self-service solutions. Additionally, you will work cross-functionally with Engineering, Sales, Finance, Marketing, and Customer Relations to translate data requirements into impactful solutions. Your contributions will also include establishing best practices in analytics and mentoring team members to uphold high standards in data governance and insight generation.