Principal Scientist in Process Chemistry

About Us: Calico Life Sciences LLC, a pioneering research and development company founded by Alphabet, is dedicated to exploring advanced technologies and biological systems that enhance our understanding of human aging. Our mission is to utilize this knowledge to develop interventions that promote longer, healthier lives. With cutting-edge technology labs a…

Role Overview Oric Pharmaceuticals is seeking an Associate Director of Process Chemistry based in South San Francisco. This position shapes the direction of drug development by designing and refining synthetic routes for new therapeutic candidates. The work emphasizes both operational efficiency and scalability. What You Will Do Lead a team of chemists focused on process chemistry projects Guide the design and optimization of synthetic methods for new drug candidates Develop processes that meet standards for safety, compliance, and scientific rigor Promote collaboration and support a culture of innovation within the team Growth and Development Oric Pharmaceuticals offers opportunities for ongoing learning and professional advancement as part of a growing biotechnology company.

About Us:Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development entity dedicated to advancing our understanding of human aging through cutting-edge technologies and model systems. Our mission is to leverage this knowledge to develop interventions that promote longer, healthier lives. At Calico, we foster a culture of curiosity-driven science, supported by a robust drug-development pipeline in collaboration with leading academic and industry partners, making us a dynamic environment for medical innovation.Position Overview:We are on the lookout for a seasoned Scientist to join our mass spectrometry proteomics team. The ideal candidate will exhibit enthusiasm, attention to detail, and exceptional organizational skills while tackling complex scientific challenges. This role focuses on employing chemoproteomics techniques via mass spectrometry to facilitate drug discovery, involving extensive sample handling and optimization of proteomics methodologies to propel our drug discovery initiatives forward.

Who We Are: Calico Life Sciences LLC is a pioneering research and development organization founded by Alphabet, dedicated to advancing the understanding of human aging through cutting-edge technologies and model systems. Our mission is to leverage this knowledge to develop interventions that promote longer, healthier lives. With a vibrant pipeline of drug development, innovative laboratory technologies, and a commitment to curiosity-driven discovery, Calico is a dynamic environment for driving impactful medical breakthroughs. Position Overview: We are on the lookout for a highly skilled and driven Principal Associate Scientist to lead our Biomarker Group in discovering and validating pharmacodynamic, prognostic, and predictive biomarker assays. This role supports a diverse array of clinical programs, including those focused on Neuroscience, Oncology, and aging-related diseases. The ideal candidate will possess over 15 years of experience in translational biology, molecular and cellular biology, and hands-on assay development, bridging the gap between early discovery and clinical development to ensure that our therapeutic candidates are underpinned by solid biomarker strategies. Key Responsibilities: Discovery & Validation: Lead the discovery and validation of pharmacodynamic biomarkers to support the clinical development of drugs with innovative mechanisms of action using preclinical models (both in vivo and in vitro) and human specimens. Assay Development: Spearhead the development, optimization, and qualification of biomarker assays across various platforms. Data Analysis & Interpretation: Conduct thorough analyses to establish pharmacokinetic/pharmacodynamic relationships and benchmark program compounds, utilizing statistical and specialized tools to interpret results from ex-vivo and in-vitro studies, delivering actionable insights for clinical dose selection, and synthesizing complex biological data into concise reports for senior management. Clinical Translation: Manage the technical transfer of validated assays to CROs or internal bioanalysis teams for Phase I/II studies. Strategic Intelligence: Gather and analyze competitive intelligence to guide discovery strategy and provide scenario assessments for high-priority clinical assets. Mentorship: Mentor and manage junior scientists, fostering a culture of technical excellence and scientific inquiry.

About Us: Calico Life Sciences LLC, a pioneering research and development organization established by Alphabet, is dedicated to leveraging cutting-edge technologies and modeling systems to deepen our understanding of the biology underlying human aging. Our goal is to translate this knowledge into interventions that empower individuals to live longer, healthier lives. With a foundation in curiosity-driven scientific discovery and a robust drug-development pipeline in collaboration with academic and industry partners, Calico offers a dynamic environment for fostering innovative medical breakthroughs. Position Overview: We are on the lookout for a visionary Principal Scientist to connect computational design with experimental validation in our antibody discovery process. In this pivotal role, you will act as the key scientific liaison between our wet-lab antibody team and machine learning group, propelling the advancement of our "Design-Build-Test-Learn" framework. As both a project leader and technical authority, you will convert intricate in silico designs into practical experimental workflows. You will oversee the rigorous validation of computational predictions and ensure that the resulting biological data is organized to enhance and refine our internal models. We are seeking a seasoned expert in therapeutic antibody development who is eager to transcend traditional random screening methodologies and promote a rational, data-driven paradigm in biologic drug discovery.

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup that harnesses the power of artificial intelligence to revolutionize drug discovery and development. Our mission is to develop cutting-edge generative AI models that design innovative protein and antibody therapeutics, paving the way for the creation of medicines targeting previously challenging molecular targets. In addition, we are developing foundational models for biology and disease that enhance target elucidation and patient stratification. These technologies collectively aim to facilitate the ongoing discovery of novel therapies and improve the likelihood of success in drug development. Xaira proudly operates from the vibrant San Francisco Bay Area, Seattle, and London.About the RoleAs a Principal Associate Scientist within our Protein Engineering group, you will play a vital role in our interdisciplinary team composed of highly creative and skilled professionals with exceptional expertise in protein characterization and engineering. This group is instrumental in driving our AI drug discovery initiatives and optimizing lead molecules. You will collaborate closely with protein designers, biologists, and other members of the drug discovery team.We are seeking an exceptional library builder who possesses the ability to design, generate, and scale complex DNA assemblies for our protein engineering and display teams. This role demands extensive experience in combinatorial, designed, and naive library building, along with the necessary microbiological and protein-level expertise to express and qualify these assemblies once constructed. This hands-on position is ideal for someone who can seamlessly integrate NGS, protein biochemistry, and DNA assembly needs while building complex libraries efficiently.About YouYou are a passionate protein biochemist who takes pride in your laboratory skills. Your enthusiasm lies in display technology, drug discovery, and the development of innovative treatments for patients. You are detail-oriented, organized, and thrive on collaboration. You flourish in a fast-paced environment where pushing the boundaries of what is possible is the norm.What You'll Do and LearnDesign and implement various innovative selection techniques using synthetic libraries, including phage, yeast, and mammalian display.Utilize FACS sorting, plate-based screening, and NGS to identify binders.Establish and employ automation to further rank leads based on affinity and function.Collaborate with cross-functional teams to troubleshoot protein reagents.Train and mentor junior team members.

Position SummaryCellares is on the lookout for a dynamic and driven Senior Scientist with a strong background in cell therapy manufacturing to become a vital member of our Process Development team. This role offers a unique opportunity to collaborate with various departments and make substantial contributions to the advancement of our innovative cell therapy manufacturing platform.In this pivotal position, you will be responsible for designing, coordinating, executing, and analyzing experiments related to cell therapy process development. Your efforts will be instrumental in enhancing and optimizing the Cellares platform. The ideal candidate will exhibit exceptional organizational skills, demonstrate technical leadership, and possess a proven track record in developing robust autologous and allogeneic cell therapy processes.We seek individuals who thrive in a fast-paced, mission-driven environment and are eager to embrace a diverse range of challenges as Cellares continues to expand.

About UsDeep Apple Therapeutics, a dynamic biotechnology firm within the Apple Tree Partners (ATP) portfolio, is located in the heart of the Bay Area. Our mission is to revolutionize drug discovery by leveraging advanced molecular docking and structural biology techniques. By utilizing cutting-edge computer-aided drug design technologies and a state-of-the-art research platform, we are committed to accelerating the development of innovative therapeutic solutions.Role OverviewWe are in search of a seasoned and innovative leader to take on the role of Head of Computational Chemistry. This pivotal position involves directing our computational initiatives for virtual hit discovery. Reporting directly to the Head of Drug Discovery, you will lead a talented team of computational chemists, data scientists, and machine learning engineers, enhancing our drug discovery pipeline through the integration of advanced deep learning models. Your leadership will be critical in refining our virtual screening capabilities, optimizing molecular design, and fostering cross-functional collaborations to transform computational insights into effective therapeutic leads. We seek a candidate with a minimum of 10 years of experience in computational modeling, particularly in applying deep learning techniques to drug discovery.Key ResponsibilitiesGuide and mentor a diverse team in creating and optimizing computational chemistry workflows for virtual hit discovery, including both ligand-based and structure-based modeling.Develop and implement deep learning models (including generative AI for molecule design) to accurately predict molecular properties, binding affinities, and ADMET profiles.Oversee the integration of high-throughput virtual screening platforms, utilizing extensive datasets and cloud computing resources (AWS and Google Cloud).Work collaboratively with biology, medicinal chemistry, and machine learning teams to validate computational predictions through iterative feedback loops.Lead strategic initiatives, forming partnerships with academic institutions, technology companies, and CROs to bolster our AI-driven discovery capabilities.Stay informed about emerging technologies in computational chemistry and deep learning, incorporating these advancements into our workflow to maintain a competitive advantage.Manage project timelines, budgets, and resources, ensuring compliance with data integrity and intellectual property standards.

About Us: Calico Life Sciences LLC, a cutting-edge research and development firm founded by Alphabet, is dedicated to unraveling the complexities of human aging through advanced technologies and innovative model systems. Our mission is to leverage this understanding to create interventions that promote longer, healthier lives. With state-of-the-art technology labs, a culture of curiosity-driven discovery, and a robust pipeline of drug development in collaboration with both academic and industry partners, Calico is an inspiring environment for catalyzing medical breakthroughs. Job Overview: We are on the lookout for a dynamic and passionate Scientist/Senior Scientist in Aging Biology to become a pivotal member of our Translational Medicine team. In this vital role, you will investigate the mechanisms of action (MOA) of therapeutic targets within our aging biology pipeline. The successful candidate will define the molecular and cellular pathways integral to our research programs, translating novel in vivo findings into a profound mechanistic understanding that will guide clinical development. The ideal candidate will possess substantial expertise in cell biology, MOA studies, and complex signaling pathways. Key Responsibilities: Design and implement experimental strategies to elucidate the molecular and cellular mechanisms of action for aging-related targets and biomarkers, providing insights that steer program direction. Execute in vitro and ex vivo studies to explore target biology in significant aging-related processes, such as stem cell function, tissue repair, and signaling or transcriptional regulation. Analyze acute and chronic pathway modulation in tissue injury and aging models to comprehend the evolution of stress responses and repair mechanisms in aging. Investigate the molecular drivers of in vivo phenotypes in preclinical aging models to identify biomarkers and translatable mechanisms for clinical development. Collaborate with in vivo pharmacology and biomarker teams to select optimal preclinical models that effectively probe target biology. Engage with cross-functional teams (e.g., Biomarkers, Genomics, Protein Sciences) to integrate multi-omic datasets and construct a comprehensive mechanistic framework. Analyze, interpret, and present complex data along with strategic recommendations to internal project teams and senior leadership. Maintain rigorous experimental documentation and contribute to internal reports, publications, and regulatory submissions.

Join our dynamic team at Mindlance as an Associate Scientist. In this pivotal role, you will contribute to groundbreaking research initiatives and assist in the development of innovative solutions within the scientific community. Your expertise and analytical skills will help drive forward our mission to advance scientific knowledge and technology.

About Us: Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development entity dedicated to advancing our understanding of the biological mechanisms of human aging. Our mission is to leverage cutting-edge technologies and innovative model systems to create interventions that promote longer, healthier lives. With our state-of-the-art laboratories, commitment to curiosity-driven discovery, collaborative partnerships across academia and industry, and a dynamic drug development pipeline, Calico is an inspiring environment for driving impactful medical breakthroughs. Position Overview: The Cellular Models and Assay Technologies (CMAT) laboratory and the Microscopy group at Calico are in search of a highly skilled and driven bench Scientist to join our innovative teams. This position is at the forefront of spatial biology, concentrating on the intricate mapping of molecular environments involving proteins and protein complexes within both live and fixed cells and tissues. The ideal candidate will spearhead the creation and application of Laser Capture Microdissection (LCM) workflows integrated with various proximity biotinylation techniques to achieve exceptional resolution in multiomics experiments specific to cells and tissues. As a crucial member of our drug discovery and fundamental research initiatives, the successful applicant will play a significant role in identifying and validating novel therapeutic targets and biomarkers. This hands-on position necessitates a profound understanding of cell and tissue biology, biochemistry, microscopy, and image analysis, along with the capability to develop or adapt novel methodologies as required. We seek an independent, adaptable, and proactive scientist with outstanding communication skills who can effectively manage complex studies in a fast-paced environment.

Join our dynamic team at Artech Information Systems LLC as a Bench Scientist. This entry-level role offers an exciting opportunity to work in a laboratory environment, contributing to innovative scientific research and experiments.

Join our dynamic team as an Analytical Scientist where you will play a pivotal role in driving scientific innovations. In this contract position, you will leverage your analytical expertise to conduct experiments, analyze data, and contribute to cutting-edge projects that impact our future.

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup dedicated to revolutionizing drug discovery and development through the power of artificial intelligence (AI). Our mission is to lead the advancement of generative AI models designed specifically for creating innovative protein and antibody therapeutics. This allows us to tackle previously challenging molecular targets and develop effective medicines. We are also at the forefront of developing foundational models for biology and disease, facilitating improved target identification and patient stratification. Through our cutting-edge technologies, we aim to consistently discover novel therapies and enhance the success rates of drug development. Xaira has its headquarters in the vibrant San Francisco Bay Area, Seattle, and London.Position OverviewWe are on the lookout for dynamic and passionate candidates to join our innovative team as an AI Scientist! In this role, you will leverage your experience in developing and implementing advanced deep learning methodologies, showcasing a proven record of AI innovation through publications in the fields of Artificial Intelligence or Machine Learning, or through significant interdisciplinary projects. As a vital member of our core AI team, composed of exceptionally talented and creative individuals, you will spearhead exciting projects aimed at advancing state-of-the-art AI models in biology that influence drug discovery and clinical development. This role also provides the opportunity to collaborate with interdisciplinary experts in world-class biology, drug discovery, and clinical domains. Xaira values diversity and encourages candidates from all backgrounds and experiences to apply, as we believe that teams thrive when varied perspectives are included.The position is available in the following locations: San Francisco Bay Area, Seattle, and London.

About Us: Calico Life Sciences LLC, founded by Alphabet, is a pioneering research and development firm with the mission to leverage cutting-edge technologies and experimental systems to deepen our understanding of the biology behind human aging. Our goal is to translate this knowledge into innovative interventions that enhance the quality and longevity of life. With a vibrant drug-development pipeline and a commitment to curiosity-driven scientific exploration, Calico offers a dynamic environment where medical breakthroughs are catalyzed and realized. Position Overview: We are on the lookout for a dedicated in vivo scientist to propel our neurodegenerative disease research forward, specifically targeting Parkinson's disease. This role is vital for designing, executing, and interpreting experiments utilizing rodent models to explore neurological and aging disorders while evaluating potential therapeutic interventions. The successful candidate will enhance our Translational Neuroscience team's capacity for in vivo research, establish sophisticated models for thorough investigation, and assess novel drug mechanisms of action. Additionally, the scientist will contribute to modeling innovative aspects of neurodegenerative diseases, integrate insights from human cohorts, and develop mechanistic models for hypothesis testing stemming from new target discoveries. Key Responsibilities: Develop and characterize novel in vivo models related to neurodegeneration and age-associated biology. Design and implement in vivo functional experiments for target validation and mechanistic biology studies. Conduct comprehensive animal behavioral assessments to delineate neurological phenotypes. Analyze, interpret, and effectively communicate data and results to the team. Maintain meticulous records of experiments, data, and findings in compliance with Calico guidelines. Participate in experimental design, data interpretation, and results presentation. Foster collaboration across multiple functional teams. Ensure adherence to all animal welfare regulations and institutional guidelines.

Join our dynamic team as a Scientist I and contribute to groundbreaking research that drives innovation in the field. You will be an integral part of our scientific community, focusing on developing solutions that enhance our understanding of complex biological systems.

Join Veracyte, a trailblazing organization dedicated to revolutionizing cancer care for patients worldwide. At Veracyte, our team members have the opportunity to make a significant difference in patients' lives while thriving in a mission-driven environment. We embrace the Veracyte way, which emphasizes collaboration, guided by our core values, to equip clinicians with the insights necessary for transformative patient care.Our Core Values:Innovative Mindset: We boldly pursue innovation, learn from challenges, and remain steadfast in our commitment to enhancing cancer care.Action-Oriented: We prioritize urgency, uphold quality standards, and infuse enjoyment into our dedicated efforts.Collaborative Spirit: We engage in open dialogue, strive for understanding, and celebrate our collective achievements.Deep Care: We honor our diversity, uphold ethical standards, and support each other.Position Overview:We are in search of an accomplished and passionate Bioinformatics Scientist to become a key member of our Bioinformatics and Data Science Team, focused on the creation of regulated diagnostic products. The ideal candidate will possess extensive knowledge of NGS technologies and a robust understanding of regulatory frameworks such as CAP/CLIA and IVD product development. This role is pivotal in the design, development, and optimization of our next generation of genomic assays. A unique combination of bioinformatics expertise, assay optimization experience, analytical validation skills, and a strong foundation in molecular biology is essential, along with a commitment to transforming complex biological data into actionable insights.

Join Veracyte as a Senior Computational Development Scientist, where you will play a pivotal role in our mission to transform patient care through innovative genomics. In this remote position, you will leverage cutting-edge computational techniques to analyze complex genomic data, contributing to groundbreaking discoveries in cancer diagnostics.

We are seeking a dedicated and detail-oriented Bench Scientist to join our innovative team located in South San Francisco. As a Bench Scientist, you will be responsible for conducting experiments, analyzing results, and contributing to our research projects. This is an excellent opportunity for individuals who are passionate about scientific discovery and wish to advance their careers in a dynamic environment.

About Xaira TherapeuticsXaira Therapeutics is a cutting-edge biotechnology startup that harnesses the power of artificial intelligence to revolutionize drug discovery and development. Our mission is to pioneer generative AI models that design innovative protein and antibody therapeutics, targeting previously challenging molecular entities. We are also creating foundational models to enhance biological and disease understanding, facilitating improved target identification and patient stratification. Our technologies aim to consistently identify breakthrough therapies and elevate success rates in drug development. Xaira is proudly headquartered in the San Francisco Bay Area, with additional locations in Seattle and London.About the RoleWe are seeking a passionate and detail-oriented protein biochemist who excels in hands-on laboratory execution. Your enthusiasm for display technology and drug discovery will drive you as you work towards developing transformative treatments for patients. You thrive in collaborative and fast-paced settings, continuously seeking to push the frontiers of scientific innovation.