About the job
Job Title: Analytical Chemist – Oligonucleotides
Location: Boston, MA (Hybrid – 3 days onsite)
Duration: 12 months (extension possible)
The Analytical Chemist will play a crucial role in the Technical Operations Analytical team, primarily focusing on providing analytical support for oligonucleotides and peptides in late-stage development. This position requires a strong background in laboratory instrumentation and oligonucleotide expertise.
Key Responsibilities:
- Deliver analytical support for oligonucleotide and peptide-oligonucleotide conjugated compounds in late-stage development.
- Develop, optimize, and validate robust LC/MS, IP-RP-HPLC, and SAX-HPLC analytical methods tailored for the analysis and purification of highly modified oligonucleotide drug substances.
- Conduct analytical testing using a variety of systems including IP-RP-HPLC, AX-HPLC, UPLC, LC-MS, and LC-MS/MS (Agilent, Waters, Thermo) along with associated data software.
- Operate, maintain, and troubleshoot laboratory instrumentation to guarantee accurate and reliable results.
- Ensure adherence to GLP/GMP standards within a regulated pharmaceutical setting.
- Compose technical documents such as protocols, reports, and method validation documents; effectively communicate findings across cross-functional teams.
- Work independently while fostering collaboration with Technical Operations, Quality, and Manufacturing teams.

