About the job
Attention recruitment agencies: All inquiries from agencies are managed through 4D Molecular Therapeutics’ internal Talent Acquisition team. Unsolicited resumes will not be considered. Agencies must engage with our Talent Acquisition team for any requisition. Direct contact with hiring managers will not be tolerated and may affect future collaboration with 4DMT.
4D Molecular Therapeutics is a pioneering late-stage biotechnology firm dedicated to advancing durable and disease-targeted therapeutics that hold the potential to revolutionize treatment methodologies and deliver extraordinary benefits to patients. Our flagship product candidate, 4D-150, is engineered as a foundational therapy for blinding retinal vascular diseases, offering multi-year sustained delivery of anti-VEGF (aflibercept and anti-VEGF-C) through a single, safe intravitreal injection, significantly alleviating the treatment burden associated with conventional bolus injections. Currently, 4D-150 is in Phase 3 development for wet age-related macular degeneration, with a second indication being diabetic macular edema. Additionally, our second product candidate, 4D-710, is the first known genetic medicine to successfully deliver and express the CFTR transgene in the lungs of cystic fibrosis patients following aerosol delivery.
GENERAL SUMMARY:
Reporting to the VP of Clinical Development or the CMO, the Executive Medical Director will be responsible for the strategic design, implementation, and analysis of clinical trials within the Ophthalmology Therapeutic Area.
MAJOR DUTIES & RESPONSIBILITIES:
- Provide clinical leadership to multidisciplinary study execution teams encompassing clinical operations, clinical science, biometrics, regulatory affairs, CMC, pharmacology/toxicology, drug safety, commercial sectors, and alliance partners.
- Hold primary accountability on study teams for the successful delivery of study protocols, study conduct, and readouts.
- Organize and facilitate scientific advisory board meetings, engaging with external experts and stakeholders to gather critical insights.
- Act as the medical monitor for clinical studies.
- Serve as the principal clinical author of development plans, study protocols, amendments, informed consent forms (ICFs), investigator brochures (IBs), investigational new drug applications (INDs), annual reports, clinical study reports (CSRs), and all regulatory submissions/correspondence. Ensure the accuracy of all medical content within these documents.

