About the job
JOB SUMMARY
iambic therapeutics is on the lookout for a talented and motivated Analytical/Bioanalytical Scientist specializing in chromatography-based purification to enhance our drug discovery initiatives. The chosen candidate will be instrumental in facilitating high-throughput purification and assay workflows, supporting a weekly design-make-test-analysis cycle driven by our proprietary AI-based drug discovery engine. The ideal individual will possess extensive expertise in chromatographic purification, particularly in SFC and/or LC purification of small molecules, along with demonstrated skills in instrument troubleshooting, workflow optimization, and a solid understanding of ADME/DMPK assay design and execution.
KEY RESPONSIBILITIES
Act as the authority in chromatography-based purification, leveraging significant experience in SFC and LC purification of small molecules within a drug discovery context.
Create, implement, and refine purification workflows, including preparative chromatography methods, fraction collection strategies, and post-purification data integration.
Design and sustain automated purification workflows to enhance throughput, reproducibility, and sample quality.
Work collaboratively with medicinal chemistry, purification, and DMPK teams to supply high-quality purified compounds, aiding in lead optimization and screening.
Provide direct support, preventive maintenance, and troubleshooting for LC, LC/MS, and SFC instruments to reduce downtime and ensure continuous lab operations.
Engage with vendors and automation partners for service, upgrades, installations, and workflow integration.
Potentially assist with ADME/DMPK and physicochemical assays, contributing to method development, troubleshooting, and execution as required.
Document purification workflows, maintenance activities, and troubleshooting in line with laboratory best practices.
QUALIFICATIONS
Possession of an advanced degree (M.S. or Ph.D.) in Analytical Chemistry, Chemistry, Chemical Engineering, or a related discipline; or equivalent industry experience.
A minimum of a Ph.D. with 2 years of relevant experience OR an M.S. with 6 years of relevant experience.
Extensive hands-on experience with chromatography-based purification, particularly SFC and/or LC purification of small molecules.
Strong proficiency in operating, maintaining, and troubleshooting chromatography and mass spectrometry instruments.

