About the job
Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. Unsolicited resumes will not be accepted. The 4DMT Talent Acquisition team must expressly engage agencies on any requisition. Agencies contacting hiring managers directly will not be tolerated, and doing so may impact your ability to work with 4DMT in the future.
4D Molecular Therapeutics (4DMT) is a pioneering biotechnology company dedicated to the development of transformative, durable, and disease-targeted therapeutics aimed at revolutionizing treatment paradigms and delivering unprecedented benefits to patients. Our lead product candidate, 4D-150, is engineered to serve as a foundational therapy in treating blinding retinal vascular diseases through the multi-year delivery of anti-VEGF agents via a single, safe intravitreal injection. This innovative approach significantly alleviates the treatment burden associated with traditional bolus injections. Currently in Phase 3 development, 4D-150 targets wet age-related macular degeneration, with a secondary focus on diabetic macular edema. Additionally, our second product candidate, 4D-710, stands as a groundbreaking genetic medicine that successfully delivers and expresses the CFTR transgene in the lungs of cystic fibrosis patients through aerosol delivery.
GENERAL SUMMARY:
Reporting to the VP of Clinical Science, the Senior Director, Clinical Science will be pivotal in driving the advancement of ophthalmology gene therapy programs. This role encompasses the clinical and scientific support of all assigned clinical programs.
MAJOR DUTIES & RESPONSIBILITIES:
- Collaborate with cross-functional program teams and key R&D stakeholders to develop innovative study designs, clinical trial protocols, amendments, investigator brochures, and other essential documents for conducting clinical trials.
- Provide clinical support for clinical study execution, including operational feasibility, data management, communication plans, safety monitoring, and the preparation of meeting materials and study updates.
- Assist in scientific oversight, including cleaning and querying key safety and efficacy data throughout ongoing clinical trials.
- Prepare and communicate concise overviews of trial results.
- Identify issues concerning study conduct and/or subject safety, offering preliminary assessments and collaborating with the clinical team to address these issues.

