Scientist in Nucleic Acid Biochemistry at Hsu & Konermann Labs

Arc InstitutePalo Alto, CA

On-site Full-time $121.3K/yr - $159.5K/yr

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Experience Level

Experience

Qualifications

The ideal candidate will possess a PhD in Biochemistry, Molecular Biology, or a related field, with a strong background in nucleic acid manipulation and a proven track record of innovative research. Experience with genetic engineering techniques, bioinformatics, and a collaborative spirit are essential for success in this role.

About the job

About Arc Institute

Arc Institute is a pioneering independent nonprofit research organization situated at the intersection of artificial intelligence and biology. Our mission is to expedite scientific advancements and unravel the complexities behind various diseases. Established in 2021 and located in Palo Alto, we collaborate closely with renowned institutions such as Stanford University, UC Berkeley, and UC San Francisco.

Our unique model allows scientists the liberty to engage in extensive research without the constraints of commercial pressures, supported by long-term funding and resources akin to industry standards. Our Technology Centers and Core Investigator labs synergize to tackle challenges that neither could address independently.

Our two key initiatives exemplify our innovative approach:

Virtual Cell Initiative: Constructing a comprehensive virtual cell model to uncover disease mechanisms and propose drug targets, thereby accelerating the transition from biological insights to clinical trials.
Alzheimer's Disease Initiative: Investigating the genes, pathways, and environmental influences linked to Alzheimer’s disease to create drug candidates that address its fundamental causes.

With over 300 dedicated researchers at our Palo Alto headquarters, we are backed by significant long-term philanthropic support.

About the Position

The Hsu Lab and Konermann Lab are inviting applications for a Scientist specializing in Nucleic Acid Biochemistry. This role focuses on the mechanistic exploration and engineering of Bridge Recombinases, naturally occurring RNA-guided DNA recombinases that we have recently identified and demonstrated to programmably insert, excise, and invert DNA (Nature, 2024; Science, 2025). The successful candidate will lead the next phase of the evolution of Bridge Recombinases, building on our foundational work with IS110 and ISCro4 as programmable tools. You will collaborate with an interdisciplinary team aimed at engineering bridge RNAs and recombinases for extensive genome modifications, therapeutic gene circuit integration, and seamless disease correction.

About Arc Institute

Arc Institute is at the forefront of integrating artificial intelligence with biological research to drive breakthroughs in health sciences. Our approach emphasizes long-term, high-risk research in a resource-rich environment, allowing our scientists to explore unprecedented scientific questions.

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Scientist, Genome Editing Technologies - Hsu Lab

Arc Institute

Full-time|$121.3K/yr - $159.5K/yr|On-site|Palo Alto, CA

About Arc Institute The Arc Institute is a pioneering scientific organization dedicated to curiosity-driven research and technological advancements aimed at understanding and treating complex human diseases. Based in Palo Alto, California, Arc operates as an independent research entity, collaborating with prestigious partners such as Stanford University, UCS…

Mar 10, 2026

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Scientist in Nucleic Acid Biochemistry at Hsu & Konermann Labs

Arc Institute

Full-time|$121.3K/yr - $159.5K/yr|On-site|Palo Alto, CA

About Arc Institute Arc Institute is a pioneering independent nonprofit research organization situated at the intersection of artificial intelligence and biology. Our mission is to expedite scientific advancements and unravel the complexities behind various diseases. Established in 2021 and located in Palo Alto, we collaborate closely with renowned institutions such as Stanford University, UC Berkeley, and UC San Francisco. Our unique model allows scientists the liberty to engage in extensive research without the constraints of commercial pressures, supported by long-term funding and resources akin to industry standards. Our Technology Centers and Core Investigator labs synergize to tackle challenges that neither could address independently. Our two key initiatives exemplify our innovative approach: Virtual Cell Initiative: Constructing a comprehensive virtual cell model to uncover disease mechanisms and propose drug targets, thereby accelerating the transition from biological insights to clinical trials. Alzheimer's Disease Initiative: Investigating the genes, pathways, and environmental influences linked to Alzheimer’s disease to create drug candidates that address its fundamental causes. With over 300 dedicated researchers at our Palo Alto headquarters, we are backed by significant long-term philanthropic support. About the Position The Hsu Lab and Konermann Lab are inviting applications for a Scientist specializing in Nucleic Acid Biochemistry. This role focuses on the mechanistic exploration and engineering of Bridge Recombinases—naturally occurring RNA-guided DNA recombinases that we have recently identified and demonstrated to programmably insert, excise, and invert DNA (Nature, 2024; Science, 2025). The successful candidate will lead the next phase of the evolution of Bridge Recombinases, building on our foundational work with IS110 and ISCro4 as programmable tools. You will collaborate with an interdisciplinary team aimed at engineering bridge RNAs and recombinases for extensive genome modifications, therapeutic gene circuit integration, and seamless disease correction.

May 1, 2026

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Scientist in Functional Genomics – Virtual Cell Initiative

Arc Institute

Full-time|$121.3K/yr - $159.5K/yr|On-site|Palo Alto, CA

About Arc InstituteThe Arc Institute is a pioneering scientific organization dedicated to curiosity-driven basic research and technology innovation aimed at understanding and treating complex human diseases. Located in Palo Alto, California, Arc operates as an independent research entity, collaborating closely with Stanford University, UCSF, and UC Berkeley. Our mission is founded on the belief that transformative research initiatives can be greatly enhanced by innovative institutional models.While traditional university research has achieved significant breakthroughs, we emphasize the need for institutional experimentation to further advance science. We provide:Comprehensive Funding: Arc fully finances Core Investigators' (PIs') research teams, freeing scientists from the usual constraints of project-based funding.Advanced Technology: As biomedical research increasingly relies on sophisticated tools, our Technology Centers are dedicated to developing, optimizing, and deploying cutting-edge experimental and computational technologies in partnership with Core Investigators.Exceptional Support: Our goal is to offer unparalleled operational, financial, and scientific assistance to empower researchers in pursuing ambitious, high-risk projects that can significantly impact disease treatments, including neurodegeneration, cancer, and immune dysfunction.Collaborative Culture: We recognize the critical role of culture in scientific achievement and strive to cultivate an environment that prioritizes curiosity, integrity, broad aspirations, and collaborative spirit.With over 350 professionals on board and more than $650 million in committed funding, our state-of-the-art laboratory facility in Palo Alto is set to expand rapidly in the years ahead.About the PositionWe invite applications for a highly proficient Scientist specializing in functional genomics and single-cell sequencing to join our Virtual Cell Initiative. This initiative is pioneering the development of foundational models designed to accurately predict cellular states and responses to interventions. In this pivotal role, you will lead the creation of extensive single-cell perturbation datasets across over 50 cancer cell lines, essential for training our Virtual Cell models.Your responsibilities will encompass the entire experimental workflow, from mammalian cell culture and large-scale CRISPR screening to single-cell library preparation and sequencing. This role not only demands technical expertise but also the ability to drive scientific innovation.

Feb 26, 2026

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Scientist in Antibody Discovery at Horns Lab | Palo Alto, CA

Arc Institute

Full-time|$121.3K/yr - $159.5K/yr|On-site|Palo Alto, CA

About Arc Institute The Arc Institute is a pioneering scientific organization committed to conducting innovative, curiosity-driven research and technology development aimed at understanding and treating complex human diseases. Based in Palo Alto, California, Arc operates independently and collaborates closely with esteemed institutions such as Stanford University, UCSF, and UC Berkeley. While traditional university research models have achieved remarkable successes, we believe that new institutional frameworks are crucial for advancing science. Our key initiatives include: Funding: We offer comprehensive funding for Core Investigators’ (PIs’) research groups, freeing scientists from the limitations of conventional project-based external grants. Technology: The field of biomedical research relies heavily on advanced tools. Our Technology Centers focus on developing, optimizing, and implementing cutting-edge experimental and computational technologies in collaboration with Core Investigators. Support: Arc is dedicated to providing exceptional operational, financial, and scientific support, allowing scientists to engage in long-term, high-risk, high-reward research that could significantly advance cures for diseases such as neurodegeneration, cancer, and immune dysfunction. Culture: We prioritize fostering a culture that emphasizes scientific curiosity, a commitment to truth, ambitious goals, and collaborative teamwork. Arc has grown to over 350 team members with more than $650 million in committed funding and a state-of-the-art laboratory facility in Palo Alto. We are poised for rapid expansion in the coming years. About the Position We are on the lookout for a highly skilled and driven Scientist to join the Horns Lab at the Arc Institute. In this role, you will spearhead the creation of an innovative platform designed to map human antibody specificities on a large scale. You will be pivotal in developing, optimizing, and implementing a high-throughput system for the identification of antigen-specific B cells and their antibody sequences via single-cell sequencing, thereby enhancing our understanding of human immunity and aiding in the discovery of new antibodies.

Mar 6, 2026

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Research Scientist in Speech Technologies

Hippocratic AI

Full-time|On-site|Palo Alto

About UsHippocratic AI is at the forefront of generative AI in the healthcare sector, pioneering a system capable of conducting safe and autonomous clinical conversations with patients. Our proprietary LLMs, part of the Polaris constellation, boast an impressive accuracy rate exceeding 99.9%.Why Join Our TeamRevolutionize healthcare with AI prioritizing safety. We’re creating the world’s first healthcare-exclusive, safety-oriented LLM — a groundbreaking platform aimed at transforming patient outcomes globally.Collaborate with visionaries shaping the future. Co-founded by CEO Munjal Shah alongside a team of healthcare professionals, AI innovators, and researchers from prestigious institutions, including El Camino Health, Johns Hopkins, and Stanford.Supported by top healthcare and AI investors. Our recent $126M Series C funding round, led by Avenir Growth, has propelled our valuation to $3.5B, totaling $404M in funding from notable investors like CapitalG and a16z.Build innovative solutions with industry leaders. Work alongside experts dedicated to enhancing healthcare, advancing scientific discoveries, and developing transformative technologies that ensure our platform is powerful and trustworthy.Location RequirementTo foster collaboration and a robust team culture, this position requires presence in our Palo Alto office five days a week, unless stated otherwise.

Jul 31, 2024

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Digital Marketing Data Scientist at ALTEN Calsoft Labs | Palo Alto

ALTEN Calsoft Labs

Contract|On-site|Palo Alto

Join our dynamic Digital Marketing Analytics team as a Digital Marketing Data Scientist, where you'll play a critical role in addressing complex business challenges through data science. This position allows you to engage in the full lifecycle of experimentation—ranging from data-driven hypothesis formulation to test design, analysis, and interpretation.Your insights will directly influence business optimizations across the customer journey, and you'll have the opportunity to innovate experimental methodologies to extract meaningful results.The ideal candidate will possess a robust technical background in statistics and predictive modeling, alongside significant experience in developing datasets for various data science initiatives. Exceptional communication skills and advanced analytical abilities are essential for success in this role.

Apr 12, 2019

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Postdoctoral Researcher at Horns Lab | Arc Institute | Palo Alto, CA

Arc Institute

Full-time|$80K/yr - $80K/yr|On-site|Palo Alto, CA

About the Arc InstituteThe Arc Institute is an innovative research organization dedicated to pioneering curiosity-driven science and technology development aimed at understanding and addressing complex human diseases. Located in the vibrant city of Palo Alto, California, we partner with esteemed institutions such as Stanford University, UCSF, and UC Berkeley to push the boundaries of scientific inquiry.We are committed to reimagining traditional research paradigms, believing that a fresh institutional approach can significantly advance impactful research. Key elements of our strategy include:Funding: Our Core Investigators (PIs) receive comprehensive funding for their research groups, freeing scientists from the limitations of project-based grants.Technology: We recognize the growing reliance on sophisticated tools in biomedical research. Our Technology Centers focus on developing and optimizing cutting-edge experimental and computational technologies in collaboration with our Core Investigators.Support: We provide exceptional operational, financial, and scientific support to empower scientists to undertake long-term, high-risk research that has the potential to lead to significant advancements in the treatment of diseases, including neurodegeneration, cancer, and immune dysfunction.Culture: We believe that a strong scientific culture is essential for sustained excellence. Our aim is to cultivate an environment characterized by scientific curiosity, an unwavering commitment to truth, ambitious goals, and collaborative spirit.With a team of over 350 individuals and more than $650M in committed funding, we continue to expand rapidly, supported by a state-of-the-art laboratory facility in Palo Alto.About the PositionThe Horns Lab is on the lookout for dedicated, innovative, and inquisitive scientists. We specialize in developing and utilizing technologies that integrate synthetic biology and genomics to tackle fundamental and translational questions in human health, particularly in the realms of immunology and neuroscience. Our goal is to create novel tools and apply them to uncover mechanisms operating within complex, dynamic systems such as the immune system and brain.As a Postdoctoral Researcher in our lab, you will be encouraged to lead ambitious, independent projects that contribute to high-impact publications and prepare for a successful career in academia or industry. You will have the opportunity to collaborate extensively across Arc, Stanford, and the broader Bay Area research community.

Jan 15, 2026

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3D Reconstruction Scientist at Array Labs | Palo Alto, California

Array Labs

Full-time|On-site|Palo Alto, California

Join Array Labs, a pioneer in advanced radar systems designed to empower humanity's understanding of our ever-changing physical world.We are embarking on an ambitious mission to deploy a coordinated network of radar satellites that will generate a real-time, high-resolution 3D map of Earth. This cutting-edge technology will facilitate expedited and informed decision-making for governmental and commercial entities involved in disaster management, infrastructure durability, and critical geopolitical intelligence.At Array Labs, we meticulously design and manufacture our satellites end-to-end, delivering the globe's most sophisticated earth observation systems. Our fleet will provide unmatched accuracy, extensive coverage, and rapid responsiveness, enabling vital insights exactly when and where they are needed.As a 3D Reconstruction Scientist, you will play a pivotal role in developing and implementing algorithms aimed at reconstructing 3D structures from an array of radar and optical sensors. Your expertise in multi-view geometry, tomography, and large-scale inverse problems will be crucial as you transition methods from prototype stages to real-world application using satellite data. The innovative techniques you create will set the benchmark for the resolution, precision, and dependability of Array’s 3D offerings.Become an integral part of our rapidly expanding engineering team, contributing to the design of a groundbreaking radar satellite constellation that will greatly enhance humanity's capability to swiftly and thoroughly comprehend our dynamic planet.

Dec 11, 2025

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AI Scientist - Machine Learning Specialist

Gauss Labs

Full-time|On-site|Palo Alto, CA / Yeoksam, Seoul

Join our dynamic AI R&D team as an AI Scientist focused on Machine Learning. In this pivotal role, you will lead the development and implementation of advanced deep learning models to address real-world temporal modeling challenges in the manufacturing sector. We are in search of a candidate with extensive practical R&D experience, firmly rooted in robust theoretical principles and possessing deep expertise across various AI disciplines. The ideal candidate will exhibit a profound understanding of cutting-edge machine learning algorithms and techniques, alongside a proven record of contributions to top-tier conferences such as NeurIPS, ICML, ICLR, KDD, CVPR, or ICCV. A solid foundation in computer science and engineering is essential. Familiarity with collaborating alongside software engineering teams to scale and commercialize ML solutions will be highly regarded. This high-impact role merges foundational research, system-level design, and hands-on implementation, allowing you to work closely with cross-functional teams to create innovative solutions that drive strategic decisions and deliver significant business value.

Apr 22, 2025

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Chief of Staff at Array Labs | Palo Alto, CA

Array Labs

Full-time|On-site|Palo Alto, CA

At Array Labs, we are at the forefront of innovation, developing the world's most advanced radar imaging satellites. Our mission is to create a precise, continuously updated 3D map of the Earth, providing governments and commercial organizations with essential insights into the physical world. We manage the entire system lifecycle, from on-orbit hardware to ground software and data processing, empowering us to control performance, reliability, and the speed of enhancements.The Chief of Staff to the CEO is a dynamic execution role that requires high energy and strategic thinking. Reporting directly to the CEO, you will collaborate closely with the Engineering leadership and R&D teams to propel CEO-priority development projects from conception through to delivery. You will establish a rigorous weekly operational rhythm, clearly defining ownership and milestones, identifying risks and dependencies early on, and facilitating decisive actions to ensure smooth execution. Your role will also encompass synthesizing updates into concise, executive-level reports for leadership and the organization.This position is best suited for a high-performing operator with outstanding judgment, exceptional communication skills, and a proven history of expanding responsibilities rapidly. It is a hands-on role that demands high ownership and exposure, and it is distinct from traditional Executive Assistant duties or PMO-oriented processes. While strong analytical skills and clear communication materials are valued, the primary focus here is on driving tangible execution and achieving delivered outcomes.

Mar 13, 2026

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Radar Algorithms Engineer at Array Labs | Palo Alto, California

Array Labs

Full-time|On-site|Palo Alto, California

Join Array Labs in revolutionizing radar technology to enhance our understanding and response to the physical world.We are embarking on an ambitious project to deploy a coordinated fleet of radar satellites, designed to generate a real-time, high-resolution 3D map of the Earth. This innovative endeavor will empower governmental and commercial entities to make quicker, more informed decisions in areas such as disaster response, infrastructure stability, and critical geopolitical intelligence.At Array Labs, we undertake the design and construction of our satellites from start to finish, crafting the most sophisticated earth observation systems in existence. Our satellite fleet will provide unmatched accuracy, extensive coverage, and rapid responsiveness, delivering vital insights exactly where they are needed.As a Radar Algorithms Engineer, you will be at the forefront of developing, implementing, and scaling groundbreaking 3D reconstruction algorithms and processing methods for our state-of-the-art radar imaging system. You will collaborate closely with the software team and engage with hardware and product teams to accelerate the transition of image formation techniques from initial concepts to a fully operational cloud-based imagery production pipeline.Be a part of our rapidly expanding engineering team, and contribute significantly to the design of the world's most advanced radar satellite constellation, enhancing humanity's ability to rapidly and comprehensively monitor our dynamic planet.

Dec 11, 2025

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Lab Support Engineer

Artech Information Systems LLC

Contract|On-site|Palo Alto

Join our team as a Lab Support Engineer where you will play a vital role in ensuring the smooth operation of laboratory equipment and systems. You will be responsible for troubleshooting, maintaining, and providing technical support for lab instruments, while also collaborating with scientists and engineers to optimize lab processes. Your expertise will help drive innovation and facilitate critical research activities.

Apr 18, 2017

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Electrical Test Engineer at Array Labs | Palo Alto, California

Array Labs

Full-time|On-site|Palo Alto, California

Join Array Labs, where we are pioneering advanced radar systems to enhance our understanding of our physical world.We are rolling out a synchronized fleet of radar satellites to generate a real-time, high-resolution 3D map of the Earth. This innovative technology will empower government and commercial entities to make quicker, more informed decisions in disaster response, infrastructure resilience, and critical geopolitical intelligence.Our team designs and constructs these satellites from the ground up, aiming to deliver the most sophisticated Earth observation systems available. Our constellation will provide unmatched levels of accuracy, coverage, and responsiveness, delivering vital insights precisely where they are needed.As an Electrical Test Engineer, you will be instrumental in developing the hardware, procedures, and automated testing infrastructure that validate our radar payloads and satellite electronics. Your responsibilities will include designing test fixtures and harnesses, creating FPGA- and software-driven test interfaces, and developing comprehensive test plans at both board and system levels. You will conduct environmental and functional testing across diverse operating conditions and collaborate with a multidisciplinary team of engineers to troubleshoot issues, ensure performance validation, and confirm flight readiness. The test systems you create will directly influence hardware reliability, calibration stability, and overall system performance in orbit.As a vital member of our rapidly expanding engineering team, you will contribute to the creation of the world’s most advanced radar satellite constellation, enhancing our ability to understand and respond to our planet's changes.

Dec 11, 2025

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Senior/Staff Applied Scientist at Gleanwork | San Francisco Bay Area

Glean

Full-time|$175K/yr - $230K/yr|On-site|San Francisco Bay Area

About Glean:Founded in 2019, Glean is a pioneering AI-driven knowledge management platform that empowers organizations to swiftly locate, organize, and share information within their teams. By seamlessly integrating with tools like Google Drive, Slack, and Microsoft Teams, Glean ensures that employees have access to vital knowledge precisely when they need it, enhancing productivity and fostering collaboration. Our state-of-the-art AI technology simplifies knowledge discovery, allowing teams to efficiently utilize their collective intelligence.Glean was conceptualized by Founder & CEO Arvind Jain, who recognized the difficulties employees encounter in finding and comprehending information at work. Observing how fragmented knowledge and cumbersome SaaS tools hinder productivity, he aimed to create a superior solution—an AI-powered enterprise search platform that enables users to swiftly and intuitively access the information they require. Today, Glean stands as a leader in the Work AI space, merging enterprise-grade search, an AI assistant, and robust application- and agent-building capabilities to redefine employee workflows.About the Role:Glean is assembling a premier Data Organization that includes product data science, applied science, data engineering, and business intelligence teams. This position is an applied science role based in our Palo Alto or San Francisco office and involves:A/B Experimentation:Collaborating with product data science and engineering teams to identify enhancements in techniques, tools, and processes for A/B experimentation, facilitating informed decision-making across all relevant product areas.Developing and maintaining our A/B experimentation platform informed by stakeholder feedback.Writing code or identifying vendors to implement these techniques into production in a scalable and user-friendly manner for engineering and product teams.

Oct 14, 2025

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Senior Clinical Scientist

Ascendis Pharma

Full-time|$170K/yr - $170K/yr|Hybrid|Palo Alto, California, United States

Ascendis Pharma is a vibrant and rapidly expanding global biopharmaceutical company with a presence in Denmark, Europe, and the United States. We are focused on advancing innovative programs in Endocrinology, Rare Disease, and Oncology.At Ascendis, we are proud of our commitment to exceptional scientific research, visionary leadership, and a dedicated team of passionate professionals.Guided by our core values of Patients, Science, and Passion, we leverage our proprietary TransCon® drug development platform to achieve our mission of creating new and potentially best-in-class therapies that address critical unmet medical needs.Our culture promotes an environment where talented, flexible, and highly resourceful professionals can truly leave their mark. We provide a dynamic workplace that encourages employees to grow and enhance their skills.As a Senior Clinical Scientist, you will play a pivotal role in the design, oversight, and data analysis of the company’s late-phase clinical trials focused on therapies involving growth hormone, parathyroid hormone, and/or C-type natriuretic peptide. This position is integral to our Clinical Development team and is ideally based in our Palo Alto, CA office; however, we may consider a remote arrangement for exceptional candidates.

Dec 30, 2025

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Lab Automation Engineer at Voltai | Palo Alto

Voltai

Full-time|On-site|Palo Alto Office

About VoltaiVoltai is at the forefront of developing sophisticated world models and intelligent agents capable of learning, evaluating, planning, experimenting, and interacting with the physical environment. Our initial focus is on the realms of hardware development, electronics systems, and semiconductors where artificial intelligence can surpass human cognitive capabilities in design and creation.About the TeamSupported by leading investors from Silicon Valley, as well as Stanford University, our team includes distinguished individuals such as former Stanford professors, SAIL researchers, Olympiad medalists, and executives from industry giants like Google, AMD, Broadcom, and Cadence. Our diverse expertise encompasses technology, defense, and policy, with a mission to innovate and lead in the field of AI and hardware.About this RoleAs a Lab Automation Engineer, you will be responsible for designing, implementing, and managing the automation infrastructure that supports Voltai’s hardware validation laboratories. This role involves building systems that facilitate automated testing, characterization, and qualification of silicon and board-level designs by seamlessly integrating software, robotics, and data pipelines for ongoing validation and enhancement.

Nov 12, 2025

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Senior Applied Scientist

Hippocratic AI

Full-time|On-site|Palo Alto

About UsAt Hippocratic AI, we are at the forefront of generative AI in the healthcare sector. Our innovative platform excels in facilitating safe, autonomous clinical conversations with patients, utilizing our proprietary LLMs within the Polaris constellation, achieving an unparalleled accuracy rate of over 99.9%.Why You Should Join UsLead the Revolution in Healthcare AI. We are developing the world’s first healthcare-specific, safety-centric LLM, aimed at significantly enhancing patient outcomes worldwide. This is an opportunity to be part of a groundbreaking initiative.Collaborate with Visionaries. Co-founded by CEO Munjal Shah and a team of esteemed professionals including physicians, hospital executives, AI innovators, and researchers from prestigious institutions like Johns Hopkins and Stanford, you will be working alongside the best minds shaping the future of healthcare.Join Our Well-Backed Venture. We recently secured a $126M Series C funding round, elevating our valuation to $3.5B with total funding reaching $404M, supported by top-tier investors such as Avenir Growth and a16z.Be Part of a Transformative Team. Work with experts dedicated to advancing healthcare, improving care quality, and pioneering technologies that make a real difference.Location RequirementWe believe that collaboration fosters innovation. This role requires you to be present at our Palo Alto office five days a week to cultivate a strong team culture.About the RoleAs a Senior Applied Scientist, you will oversee the RL-based post-training pipeline to enhance our models' clinical reasoning, safety, and alignment in healthcare applications. Your contributions will directly impact millions of patients across various clinical contexts.Your ResponsibilitiesDesign and refine RL-based post-training strategies including RLHF, RLVR, and DPO.Develop and assess reward models, verifiers, and LLM-as-judge systems.Create conversational AI environments and simulations for healthcare RL training utilizing synthetic data.

Apr 6, 2026

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Scientist in Cellular Engineering

Arc Institute

Full-time|$121.3K/yr - $159.5K/yr|On-site|Palo Alto, CA

About Arc Institute The Arc Institute is an innovative scientific organization dedicated to curiosity-driven fundamental research and technology development aimed at understanding and treating complex human diseases. Based in Palo Alto, California, we partner with prestigious institutions such as Stanford University, UCSF, and UC Berkeley to push the boundaries of scientific exploration. At Arc, we believe in pioneering new institutional models that foster transformative research. We fully fund our Core Investigators’ research teams, freeing them from the constraints of traditional project-based grants. Our Technology Centers are at the forefront of biomedical research, enhancing experimental and computational technologies in collaboration with our scientists. We strive to provide unparalleled operational, financial, and scientific support, enabling our researchers to tackle long-term, high-risk endeavors that could lead to breakthroughs in areas like neurodegeneration, cancer, and immune dysfunction. As an organization, we prioritize a culture of scientific inquiry, integrity, ambition, and collaborative spirit, understanding that a positive environment is crucial for sustained scientific excellence. With nearly 300 employees and over $650 million in committed funding, Arc is expanding rapidly, equipped with a state-of-the-art laboratory facility in Palo Alto. About the Position We are on the lookout for a dynamic Scientist specializing in cellular engineering and stem cell biology to join our Molecular Engineering team within the Genome Engineering Technology Center. This role involves designing, generating, and characterizing engineered human pluripotent stem cell (hPSC) lines for genetic perturbation screens in complex organoid models, aimed at exploring the genetic underpinnings of neurodegenerative disorders. Key projects include creating optimized effector systems for robust gene knockdown and activation throughout differentiation, introducing rare coding variants to model disease-associated mutations, and implementing cutting-edge genome engineering technologies to enhance perturbation capabilities. Your contributions will be vital to the Institute's Alzheimer’s Disease Initiative, a comprehensive effort to advance our understanding of this critical area.

Mar 4, 2026

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Postdoctoral Researcher at Gilbert Lab | Palo Alto, CA

Arc Institute

Full-time|$80K/yr - $80K/yr|On-site|Palo Alto, CA

Join the Arc InstituteThe Arc Institute represents a pioneering scientific endeavor dedicated to advancing fundamental research and technology aimed at understanding and treating complex human diseases. Located in the heart of Palo Alto, California, we are an independent research organization that collaborates closely with leading institutions such as Stanford University, UCSF, and UC Berkeley.While traditional university research models have led to significant breakthroughs, we advocate for innovative institutional approaches that can further scientific progress. Our model includes:Comprehensive Funding: We fully fund our Core Investigators’ research initiatives, liberating scientists from the constraints of conventional grant-based funding.Advanced Technology: Our Technology Centers are at the forefront of biomedical research, developing and optimizing cutting-edge experimental and computational tools in partnership with our Core Investigators.Exceptional Support: We provide unparalleled operational, financial, and scientific support, empowering researchers to pursue high-risk, high-reward projects that can lead to breakthroughs in areas such as neurodegeneration, cancer, and immune dysfunction.Collaborative Culture: At Arc, we understand that a thriving scientific culture is crucial for sustained excellence. We are committed to fostering an environment centered around curiosity, truth, ambition, and collaboration.With over 350 dedicated team members and more than $650 million in committed funding, our state-of-the-art lab facility in Palo Alto is poised for rapid growth in the coming years.About the PositionThe Gilbert Lab seeks enthusiastic, diligent, and inquisitive candidates. Our research focuses on synthetic biology, functional genomics, and epigenetics, particularly utilizing CRISPR methodologies to modulate transcription. We are dedicated to understanding the mechanisms that determine and maintain cellular identity and the epigenome, and we aim to leverage our knowledge in epigenetics and synthetic biology to develop innovative therapeutic strategies addressing cancer, viral biology, and neurodegeneration.

Jan 15, 2026

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Postdoctoral Researcher at Jain Lab | Palo Alto, CA

Arc Institute

Full-time|$80K/yr - $80K/yr|On-site|Palo Alto, CA

About Arc Institute The Arc Institute is an innovative scientific institution dedicated to curiosity-driven basic science and technology development aimed at understanding and treating complex human diseases. Based in Palo Alto, California, Arc operates as an independent research organization, collaborating closely with renowned institutions such as Stanford University, UCSF, and UC Berkeley. While traditional university research models have achieved remarkable successes, we firmly believe in the power of institutional experimentation to catalyze progress. Our unique approach includes: Funding: Arc provides comprehensive funding for Core Investigators’ research teams, freeing scientists from the usual limitations of project-based external grants. Technology: With the increasing complexity of biomedical research, our Technology Centers focus on developing and optimizing cutting-edge experimental and computational technologies in partnership with Core Investigators. Support: We are committed to delivering exceptional operational, financial, and scientific support that empowers researchers to undertake ambitious, high-risk projects aimed at significantly advancing cures for diseases like neurodegeneration, cancer, and immune dysfunction. Culture: We prioritize cultivating a scientific culture that values curiosity, a steadfast commitment to truth, broad ambition, and collaborative spirit. With a growing team of over 350 individuals and $650M+ in committed funding, the Arc Institute is poised for rapid expansion, backed by a state-of-the-art lab facility in Palo Alto. About the Position The Jain Lab seeks motivated, diligent, and inquisitive candidates. Our research focuses on the interplay between organisms and their environments, specifically how factors such as oxygen levels and nutrient availability influence metabolism and disease progression. We have recently identified that chronic hypoxia, akin to living at high altitudes in Peru or Nepal, may offer therapeutic benefits for mitochondrial diseases.

Jan 15, 2026

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Scientist in Nucleic Acid Biochemistry at Hsu & Konermann Labs

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