Senior Research Associate in Single Cell Screening

Arc InstitutePalo Alto, CA

On-site Full-time $87K/yr - $114.3K/yr

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Experience Level

Senior

Qualifications

The ideal candidate will possess: A strong background in single-cell RNA sequencing methodologies. Experience in generating and analyzing large-scale genomic datasets. Proficiency in computational biology and data analysis tools. Excellent collaborative skills and a passion for advancing scientific knowledge.

About the job

About Arc Institute

Arc Institute is a pioneering scientific organization dedicated to curiosity-driven basic research and technological advancements aimed at understanding and treating complex human diseases. Based in Palo Alto, California, we operate independently while collaborating with esteemed institutions such as Stanford University, UCSF, and UC Berkeley.

Emphasizing innovative institutional models, Arc Institute is committed to fostering significant research initiatives by:

Providing full funding for Core Investigators (PIs), allowing them to focus on groundbreaking research without the usual limitations of external grants.
Developing cutting-edge technologies in our Technology Centers, where we collaborate with Core Investigators to enhance and apply advanced experimental and computational methods.
Ensuring top-tier operational, financial, and scientific support, empowering scientists to engage in high-risk, high-reward research that can lead to advancements in curing diseases such as neurodegeneration, cancer, and immune dysfunction.
Cultivating a scientific culture that emphasizes curiosity, commitment to truth, ambition, and collaborative spirit.

Currently, Arc Institute has expanded to over 350 staff members and has secured more than $650 million in funding, with plans for rapid growth supported by our state-of-the-art laboratory facilities in Palo Alto.

About the Position

We are in search of a highly skilled Senior Research Associate with extensive experience in single-cell RNA sequencing to join our Virtual Cell Initiative at Arc Institute. In this role, you will play a pivotal part in generating large-scale single-cell perturbation datasets across over 50 cancer cell lines, facilitating the training of Virtual Cell models to accurately predict cellular states and responses to interventions.

Your expertise in implementing single-cell genomics technologies will be crucial for scaling our workflows to produce high-quality scRNA-seq datasets, contributing to the essential data generation for Arc’s Virtual Cell Initiative. Collaborating within a dynamic team, you will have opportunities to foster innovation and drive impactful scientific progress.

About Arc Institute

Arc Institute is at the forefront of scientific research, combining curiosity-driven exploration with cutting-edge technology to tackle some of the most pressing health challenges of our time. With a commitment to innovative institutional frameworks, we aim to create an environment where groundbreaking discoveries can thrive.

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Postdoctoral Researcher in Human Immunology at Arc Institute | Palo Alto

Arc Institute

Full-time|$80K/yr - $80K/yr|On-site|Palo Alto, CA

About Arc Institute The Arc Institute is an innovative scientific organization dedicated to advancing basic science and technology to understand and treat intricate human diseases. Based in Palo Alto, California, Arc operates as an independent research body, collaborating closely with prestigious institutions such as Stanford University, UCSF, and UC Berkele…

Jan 15, 2026

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Postdoctoral Researcher at Horns Lab | Arc Institute | Palo Alto, CA

Arc Institute

Full-time|$80K/yr - $80K/yr|On-site|Palo Alto, CA

About the Arc InstituteThe Arc Institute is an innovative research organization dedicated to pioneering curiosity-driven science and technology development aimed at understanding and addressing complex human diseases. Located in the vibrant city of Palo Alto, California, we partner with esteemed institutions such as Stanford University, UCSF, and UC Berkeley to push the boundaries of scientific inquiry.We are committed to reimagining traditional research paradigms, believing that a fresh institutional approach can significantly advance impactful research. Key elements of our strategy include:Funding: Our Core Investigators (PIs) receive comprehensive funding for their research groups, freeing scientists from the limitations of project-based grants.Technology: We recognize the growing reliance on sophisticated tools in biomedical research. Our Technology Centers focus on developing and optimizing cutting-edge experimental and computational technologies in collaboration with our Core Investigators.Support: We provide exceptional operational, financial, and scientific support to empower scientists to undertake long-term, high-risk research that has the potential to lead to significant advancements in the treatment of diseases, including neurodegeneration, cancer, and immune dysfunction.Culture: We believe that a strong scientific culture is essential for sustained excellence. Our aim is to cultivate an environment characterized by scientific curiosity, an unwavering commitment to truth, ambitious goals, and collaborative spirit.With a team of over 350 individuals and more than $650M in committed funding, we continue to expand rapidly, supported by a state-of-the-art laboratory facility in Palo Alto.About the PositionThe Horns Lab is on the lookout for dedicated, innovative, and inquisitive scientists. We specialize in developing and utilizing technologies that integrate synthetic biology and genomics to tackle fundamental and translational questions in human health, particularly in the realms of immunology and neuroscience. Our goal is to create novel tools and apply them to uncover mechanisms operating within complex, dynamic systems such as the immune system and brain.As a Postdoctoral Researcher in our lab, you will be encouraged to lead ambitious, independent projects that contribute to high-impact publications and prepare for a successful career in academia or industry. You will have the opportunity to collaborate extensively across Arc, Stanford, and the broader Bay Area research community.

Jan 15, 2026

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Postdoctoral Researcher in Epigenomic Modeling at Arc Institute | Palo Alto

Arc Institute

Full-time|$80K/yr - $80K/yr|On-site|Palo Alto, CA

About the Arc Institute The Arc Institute is an innovative scientific research organization dedicated to conducting groundbreaking basic science and technology development focused on understanding and treating complex human diseases. Based in Palo Alto, California, we operate independently while collaborating with leading institutions such as Stanford University, UCSF, and UC Berkeley. We believe that advancing scientific research requires new institutional models. Our approach includes: Comprehensive Funding: We fully finance our Core Investigators’ research teams, freeing them from the traditional constraints of project-based external grants. Advanced Technology: Recognizing the growing complexity of biomedical research, our Technology Centers develop, optimize, and deploy cutting-edge experimental and computational technologies in partnership with our Core Investigators. Exceptional Support: We provide unparalleled operational, financial, and scientific support, enabling researchers to undertake ambitious, high-risk projects aimed at significant advancements in curing diseases such as neurodegeneration, cancer, and immune dysfunction. Cultivating a Positive Culture: We prioritize a research environment that nurtures scientific curiosity, a commitment to truth, broad ambition, and collaborative spirit. Having grown to over 350 staff with more than $650 million in committed funding and a state-of-the-art lab facility, the Arc Institute is poised for rapid expansion in the coming years. About the Position The Zhou Lab is seeking passionate, diligent, and inquisitive candidates. Our specialization lies in single-cell epigenomic modeling, utilizing high-throughput single-cell multiomic technologies and computational models to investigate the spatiotemporal dynamics of gene regulation. The chosen applicant will be pivotal in pushing the boundaries of generative AI applications in biology, focusing on DNA sequences, gene regulation, and perturbation modeling. You will be tasked with developing machine learning models tailored for biological data by leveraging innovative ML architectures, interpretability techniques, and more. Furthermore, your models will be applied to significant computational biology tasks, including genome mining and molecular interaction analysis.

Mar 13, 2026

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Postdoctoral Researcher at Gilbert Lab | Palo Alto, CA

Arc Institute

Full-time|$80K/yr - $80K/yr|On-site|Palo Alto, CA

Join the Arc InstituteThe Arc Institute represents a pioneering scientific endeavor dedicated to advancing fundamental research and technology aimed at understanding and treating complex human diseases. Located in the heart of Palo Alto, California, we are an independent research organization that collaborates closely with leading institutions such as Stanford University, UCSF, and UC Berkeley.While traditional university research models have led to significant breakthroughs, we advocate for innovative institutional approaches that can further scientific progress. Our model includes:Comprehensive Funding: We fully fund our Core Investigators’ research initiatives, liberating scientists from the constraints of conventional grant-based funding.Advanced Technology: Our Technology Centers are at the forefront of biomedical research, developing and optimizing cutting-edge experimental and computational tools in partnership with our Core Investigators.Exceptional Support: We provide unparalleled operational, financial, and scientific support, empowering researchers to pursue high-risk, high-reward projects that can lead to breakthroughs in areas such as neurodegeneration, cancer, and immune dysfunction.Collaborative Culture: At Arc, we understand that a thriving scientific culture is crucial for sustained excellence. We are committed to fostering an environment centered around curiosity, truth, ambition, and collaboration.With over 350 dedicated team members and more than $650 million in committed funding, our state-of-the-art lab facility in Palo Alto is poised for rapid growth in the coming years.About the PositionThe Gilbert Lab seeks enthusiastic, diligent, and inquisitive candidates. Our research focuses on synthetic biology, functional genomics, and epigenetics, particularly utilizing CRISPR methodologies to modulate transcription. We are dedicated to understanding the mechanisms that determine and maintain cellular identity and the epigenome, and we aim to leverage our knowledge in epigenetics and synthetic biology to develop innovative therapeutic strategies addressing cancer, viral biology, and neurodegeneration.

Jan 15, 2026

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Research Associate I at Arc Institute | Palo Alto, CA

Arc Institute

Full-time|On-site|Palo Alto, CA

About Arc Institute The Arc Institute is a pioneering scientific organization dedicated to curiosity-driven basic research and technological advancements aimed at understanding and combating complex human diseases. Based in Palo Alto, California, Arc operates independently while collaborating with esteemed institutions such as Stanford University, UCSF, and UC Berkeley. We recognize that while traditional university research models have achieved remarkable successes, the exploration of innovative institutional frameworks is vital for further progress. Our core initiatives include: Funding: Arc provides comprehensive funding for Core Investigators’ research endeavors, freeing scientists from the typical constraints of project-based external grants. Technology: With an increasing reliance on sophisticated tools in biomedical research, our Technology Centers are dedicated to developing, optimizing, and implementing cutting-edge experimental and computational technologies in partnership with Core Investigators. Support: We strive to offer exceptional operational, financial, and scientific support that empowers researchers to undertake ambitious high-risk, high-reward projects that can significantly advance the quest for cures for diseases like neurodegeneration, cancer, and immune dysfunction. Culture: We believe that a strong scientific culture is crucial for sustained excellence. Our aim is to cultivate an environment that prioritizes scientific curiosity, unwavering commitment to truth, broad ambitions, and collaborative spirit. With a team of over 350 professionals and more than $650 million in committed funding, Arc is poised for rapid expansion with a state-of-the-art lab facility in Palo Alto. About the Position We are excited to invite applications for the role of Research Associate I in the Arce Lab at the Arc Institute. In this dynamic position, you will contribute to ongoing research efforts by conducting experiments and providing organizational support. Collaborating closely with the Principal Investigator, you will engage in scientific inquiries related to the immune system to enhance our understanding and treatment of immune-mediated diseases. As you advance in this role, you will have the opportunity to independently lead sub-projects under the mentorship of experienced lab members. This position is ideal for individuals eager to gain hands-on experience in biomedical research within a fast-paced environment. About You You are a self-motivated individual with a strong desire to contribute to cutting-edge research. You possess a Bachelor’s Degree in a relevant field, showcasing a solid foundation in scientific principles. Your excellent organizational skills enable you to manage multiple tasks effectively. You are eager to learn and collaborate within a team-oriented setting, demonstrating strong communication abilities.

Mar 10, 2026

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Scientist in Antibody Discovery at Horns Lab | Palo Alto, CA

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Senior Research Associate in Molecular Engineering - 6-Month Contract

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Contract|On-site|Palo Alto, CA

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Research Internship at Odyssey | Palo Alto

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Full-time|On-site|Palo Alto HQ

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Flow Cytometry Specialist

Arc Institute

Full-time|$104.5K/yr - $128.8K/yr|On-site|Palo Alto, CA

About Arc Institute The Arc Institute is an innovative scientific organization committed to conducting curiosity-driven research and developing technologies aimed at understanding and treating complex human diseases. Located in Palo Alto, California, we operate independently while partnering with esteemed institutions like Stanford University, UCSF, and UC Berkeley. While traditional university research models have achieved remarkable successes, we are dedicated to pioneering new institutional approaches to advance scientific progress. Our unique model is characterized by: Comprehensive Funding: Arc fully supports Core Investigators’ (PIs’) research groups, freeing scientists from the limitations of project-based external grants. Advanced Technology: With an increasing reliance on intricate tools in biomedical research, our Technology Centers collaborate with Core Investigators to develop, optimize, and implement cutting-edge experimental and computational technologies. Exceptional Support: We provide top-tier operational, financial, and scientific support, enabling researchers to undertake ambitious, high-risk projects focused on significant advancements in curing diseases such as neurodegeneration, cancer, and immune dysfunction. Collaborative Culture: We recognize the importance of fostering a scientific culture that prioritizes curiosity, commitment to truth, broad ambitions, and collaborative efforts. Currently, Arc boasts a team of over 350 individuals and has secured more than $650 million in funding, with plans for further expansion in our state-of-the-art laboratory facilities in Palo Alto. About the Position In this pivotal role, you will play a key part in shaping the future of the flow cytometry core service at Arc. Responsibilities include coordinating instrument usage, conducting user training, and managing daily operations. You will operate analytical and sorting cytometers, focusing on advising research teams regarding method development, assay design, and data analysis. In addition to core operations, you will help define the strategic direction of flow cytometry at Arc by benchmarking new technologies, identifying innovation opportunities, and fostering collaborative initiatives.

Mar 18, 2026

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Computational Scientist at Voltai | Palo Alto

Voltai

Full-time|On-site|Palo Alto Office

About VoltaiVoltai is at the forefront of developing advanced world models and intelligent agents designed to learn, evaluate, plan, experiment, and interact with the physical environment. Our initial focus lies in understanding and innovating hardware, specifically in electronics systems and semiconductors, where artificial intelligence can surpass human cognitive capabilities.About Our TeamOur team is backed by prominent investors from Silicon Valley, Stanford University, and high-profile leaders from companies like Google, AMD, Broadcom, and Marvell. We comprise former Stanford faculty, researchers from SAIL, medalists from international Olympiads, and executives from leading tech firms, including Synopsys and GlobalFoundries, alongside notable figures from the U.S. government.Key ResponsibilitiesDevelop and optimize MPI+CUDA PDE solvers for electrostatics, charge transport, and electromagnetic field challenges on intricate 3D IC geometries utilizing multi-node GPU clusters.Enhance and extend AMG preconditioners, Krylov solvers, and mesh pipelines, ensuring performance and correctness at scale.Construct and train neural operators (FNO, DeepONet, GNO, and variants) as high-fidelity surrogates for PDE-based field solvers.Design simulation pipelines that yield training data for neural operator models, addressing sampling strategies, mesh management, and physical consistency checks.Conduct thorough validations, including analytical solutions, published benchmarks, and cross-validation between field solvers and learned surrogates.QualificationsPhD in Computational Physics, Applied Mathematics, Computational Engineering, or a closely related discipline.Extensive knowledge of numerical PDE methods: FEM, FVM, or BEM, including weak formulations, quadrature, convergence, and error analysis.Proficient in C++ and CUDA, with a focus on writing and optimizing kernels, memory hierarchy management, and multi-GPU programming.Experience with multi-node HPC: MPI, domain decomposition, collective communication, and scaling strategies.Deep understanding of sparse linear algebra, including Krylov methods, algebraic multigrid, and preconditioning techniques.Hands-on experience with neural operators (FNO, DeepONet, or similar), encompassing training, architecture design, and evaluation on PDE datasets.Solid grasp of AI applications in scientific research.

Feb 19, 2026

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Tactile Sensing Research Engineer at 1X | Palo Alto, CA

Full-time|On-site|Palo Alto, California, United States

1XFounded in 2015, 1X is pioneering the development of sophisticated humanoid robots tailored for household applications. Our vision is to create an abundant workforce through safe and intelligent humanoid technology.We are committed to excellence in all our endeavors, tackling the toughest challenges in robotics alongside some of the brightest minds in the industry. Every component of our robots, from motor coils to artificial intelligence, is designed and manufactured in-house, showcasing our vertically integrated approach. At 1X, you will lead significant projects, receive recognition for your contributions, and be rewarded based on your performance.At 1X Labs, our goal is to drive the science and technology that facilitate human-level, general-purpose humanoids.We rigorously analyze the gap between current humanoid capabilities and the standards expected for human-level performance. This involves a deep dive into fundamental principles, taking innovative and often unconventional routes, developing groundbreaking technologies, and translating these advancements into tangible products. Our unique position allows us to transform research findings into market-ready solutions through our cohesive integration of materials, component design, systems engineering, and manufacturing.Humanoids represent a highly integrated system where genuine progress occurs only when advancements in sensing, actuation, materials, control, and intelligence harmoniously evolve—pushed to their functional limits. 1X Labs is shaped by individuals who have extensive expertise in their respective fields, capable of reasoning confidently at these boundaries and engaging meaningfully with adjacent domains, understanding which constraints are truly significant.You possess deep capabilities in your field—your intuition honed through years of tackling complex, tangible problems. Interdisciplinarity is not merely an identity for you; it is a natural outcome of mastery in systems where no single discipline suffices.You thrive in environments that value technical depth, where ideas are rigorously tested against real-world applications, and research is only validated when it successfully reaches the market..

Jan 28, 2026

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Senior Research Associate in Single Cell Screening

Arc Institute

Full-time|$87K/yr - $114.3K/yr|On-site|Palo Alto, CA

About Arc Institute Arc Institute is a pioneering scientific organization dedicated to curiosity-driven basic research and technological advancements aimed at understanding and treating complex human diseases. Based in Palo Alto, California, we operate independently while collaborating with esteemed institutions such as Stanford University, UCSF, and UC Berkeley. Emphasizing innovative institutional models, Arc Institute is committed to fostering significant research initiatives by: Providing full funding for Core Investigators (PIs), allowing them to focus on groundbreaking research without the usual limitations of external grants. Developing cutting-edge technologies in our Technology Centers, where we collaborate with Core Investigators to enhance and apply advanced experimental and computational methods. Ensuring top-tier operational, financial, and scientific support, empowering scientists to engage in high-risk, high-reward research that can lead to advancements in curing diseases such as neurodegeneration, cancer, and immune dysfunction. Cultivating a scientific culture that emphasizes curiosity, commitment to truth, ambition, and collaborative spirit. Currently, Arc Institute has expanded to over 350 staff members and has secured more than $650 million in funding, with plans for rapid growth supported by our state-of-the-art laboratory facilities in Palo Alto. About the Position We are in search of a highly skilled Senior Research Associate with extensive experience in single-cell RNA sequencing to join our Virtual Cell Initiative at Arc Institute. In this role, you will play a pivotal part in generating large-scale single-cell perturbation datasets across over 50 cancer cell lines, facilitating the training of Virtual Cell models to accurately predict cellular states and responses to interventions. Your expertise in implementing single-cell genomics technologies will be crucial for scaling our workflows to produce high-quality scRNA-seq datasets, contributing to the essential data generation for Arc’s Virtual Cell Initiative. Collaborating within a dynamic team, you will have opportunities to foster innovation and drive impactful scientific progress.

Mar 12, 2026

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AI Research Engineer - Scaling at 1X | Palo Alto, CA

Full-time|$180K/yr - $300K/yr|On-site|Palo Alto, California, United States

AI Research Engineer, Scaling | InfrastructureLocation: Palo Alto, CA (on-site)At 1X, we are pioneering the development of humanoid robots designed to collaborate with humans, addressing labor shortages and fostering abundance across various sectors.The Role: As an AI Research Engineer specializing in Scaling, you will be responsible for architecting and implementing robust infrastructure that facilitates large-scale training, evaluation, and deployment for our fleet of robots. Your contributions will be essential in transitioning experimental systems into production-ready platforms, optimized for throughput, latency, and overall performance in both datacenter and edge environments. This role will significantly impact the efficiency of learning and inference processes, directly influencing the capabilities of our general-purpose humanoid robots.

Sep 8, 2025

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AI Research Engineer at code-metal | Palo Alto, California

code-metal

Full-time|Hybrid|Palo Alto, California, United States

At code-metal, we are on a mission to revolutionize hardware deployment by matching the rapid pace of software development. Our innovative work focuses on automatic code transpilation and optimization for diverse hardware applications.As an AI Research Engineer, you will work alongside a dynamic team of researchers, tackling groundbreaking projects in generative AI and reinforcement learning.Core Responsibilities:Independently design, execute, and analyze complex experiments.Contribute to the development of core models and frameworks.Generate high-quality datasets, both real-world and synthetic.Conduct literature reviews and implement cutting-edge techniques from research papers.Engage in the publication process and present findings at conferences and workshops.Research Areas of Interest:Our current and near-term research focuses include:Contrastive representation learningSteerability and guided decodingTractable probability modelsCode-specific architecturesLLM fine-tuning, post-training, RLHF

Nov 12, 2025

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Director of Computational Biology

Arc Institute

Full-time|$233.5K/yr - $287.5K/yr|On-site|Palo Alto, CA

About Arc InstituteThe Arc Institute is a pioneering scientific institution dedicated to curiosity-driven fundamental research and technology advancement aimed at understanding and addressing complex human diseases. Based in Palo Alto, California, Arc operates as an independent research organization, collaborating closely with renowned institutions like Stanford University, UCSF, and UC Berkeley.While traditional university research has achieved remarkable outcomes, we advocate for innovative institutional models that can foster significant progress. Our core principles include:Funding: We fully support our Core Investigators' research endeavors, freeing scientists from the limitations of project-specific external grants.Technology: As biomedical research increasingly relies on sophisticated tools, our Technology Centers focus on developing, optimizing, and deploying cutting-edge experimental and computational technologies in partnership with Core Investigators.Support: We are committed to offering exceptional operational, financial, and scientific support to empower scientists in pursuing long-term, high-risk, high-reward projects that aim to make breakthroughs in curing diseases, including neurodegeneration, cancer, and immune dysfunction.Culture: We recognize the critical role of culture in scientific excellence and strive to cultivate an environment driven by scientific curiosity, unwavering commitment to truth, broad ambitions, and selfless collaboration.With a team of over 300 individuals, $650 million in committed funding, and a state-of-the-art laboratory facility in Palo Alto, we are poised to make a significant impact in the scientific community.Why this role could be your ideal opportunityTransform Data into Discovery: Step beyond conventional pipelines. You will spearhead our “Tertiary Analysis” initiatives, converting raw data into mechanistic insights that elucidate interactions between genes, drugs, and environments.Be Part of an Innovative Research Organization: Experience the dynamic fusion of startup agility and the intellectual rigor characteristic of a premier academic institute.Access Premier Datasets: Enjoy exclusive access to extensive, high-quality datasets—from T-cells and NGN2 neurons to comprehensive chemogenetic screens—specifically designed for large-scale scientific discovery.Lead with Independence: While a dedicated team manages essential bioinformatics infrastructure, you will have the autonomy to drive your research initiatives.

Feb 24, 2026

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