Senior Scientist, Discovery Biology at Rezo Therapeutics | San Francisco

Rezo TherapeuticsSan Francisco, CA

On-site Full-time

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Experience Level

Senior

Qualifications

Qualifications:Ph. D. in Biology, Biochemistry, or a related field. Strong background in cancer biology and experience with cellular assays. Proficient in genetics, proteomics, and structural biology techniques. Experience with AI applications in biological research is a plus. Excellent problem-solving skills and ability to work collaboratively in a team environment.

About the job

About Rezo Therapeutics

Rezo Therapeutics is an innovative biopharmaceutical company dedicated to revolutionizing drug development. Our vision is to significantly enhance the success rate of drug discovery through a comprehensive, disease-agnostic network biology platform that transforms our understanding of human diseases and their treatments.

We employ a unique, integrated strategy that merges genetics, proteomics, structural biology, and artificial intelligence to yield profound biological insights and to create novel therapeutic strategies.

Situated in the vibrant Mission Bay neighborhood of San Francisco, Rezo enjoys proximity to UCSF, diverse urban amenities, and abundant outdoor recreational activities. We understand that our mission's success relies equally on our talented team and our scientific endeavors, which is why we are committed to fostering a collaborative, respectful, and diverse workplace where team contributions are as valued as individual accomplishments. If you are driven by team science and eager to dismantle barriers in drug development, we invite you to consider joining us!

The Opportunity
We are seeking a Senior Scientist in Discovery Biology to join our esteemed Biology Team. In this pivotal role, you will collaborate with a multidisciplinary team of experts in genetics, proteomics, structural biology, and artificial intelligence to address complex biological challenges and develop groundbreaking therapies. This is an exceptional opportunity to apply your expertise in cancer biology to design and implement advanced cellular assays for target validation and compound screening. By joining Rezo at this exciting stage, you will have the opportunity to make a significant impact in a dynamic, collaborative setting.

About Rezo Therapeutics

Rezo Therapeutics is at the forefront of biopharmaceutical innovation, focusing on enhancing drug development processes through a unique, integrated approach that combines multiple scientific disciplines.

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Senior Automation Engineer - Drug Discovery Development Sciences

Altos Labs

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Join Altos Labs as a Senior Automation Engineer in our Drug Discovery Development Sciences team. In this pivotal role, you will leverage your expertise to advance our automated systems, enhancing the efficiency and reliability of our drug discovery processes. You will collaborate with cross-functional teams to design, implement, and optimize automation solut…

Mar 4, 2026

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Senior Scientist, Discovery Pharmacology

Altos Labs

Full-time|$225.7K/yr - $225.7K/yr|On-site|San Francisco Bay Area, CA

Altos Labs focuses on revitalizing cellular health and resilience to address disease, injury, and lifelong disabilities. The company emphasizes collaboration and inclusion, aiming to value every perspective within its team. Altos Labs has received recognition among leading biotech companies and is featured in Forbes 2026 Best Startups in America. Role overview The Senior Scientist, Discovery Pharmacology, will join the Drug Discovery and Development (3DS) division in the San Francisco Bay Area. This laboratory-based role centers on developing and executing cell-based and biochemical assays, along with complex in vitro models, to support drug discovery in rejuvenation biology and novel therapies. What you will do Investigate and validate drug targets, defining mechanisms of action through various pharmacological methods. Design, automate, and troubleshoot assays to advance discovery objectives. Analyze experimental data and present findings to guide project strategy. Maintain thorough records using an electronic lab notebook (ELN) for reproducibility and data integrity. Collaborate with cross-functional teams, including Product Development. Learn more about Altos Labs at altoslabs.com.

Apr 21, 2026

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Senior Scientist, Discovery Biology at Rezo Therapeutics | San Francisco

Rezo Therapeutics

Full-time|On-site|San Francisco, CA

About Rezo TherapeuticsRezo Therapeutics is an innovative biopharmaceutical company dedicated to revolutionizing drug development. Our vision is to significantly enhance the success rate of drug discovery through a comprehensive, disease-agnostic network biology platform that transforms our understanding of human diseases and their treatments. We employ a unique, integrated strategy that merges genetics, proteomics, structural biology, and artificial intelligence to yield profound biological insights and to create novel therapeutic strategies. Situated in the vibrant Mission Bay neighborhood of San Francisco, Rezo enjoys proximity to UCSF, diverse urban amenities, and abundant outdoor recreational activities. We understand that our mission's success relies equally on our talented team and our scientific endeavors, which is why we are committed to fostering a collaborative, respectful, and diverse workplace where team contributions are as valued as individual accomplishments. If you are driven by team science and eager to dismantle barriers in drug development, we invite you to consider joining us!The OpportunityWe are seeking a Senior Scientist in Discovery Biology to join our esteemed Biology Team. In this pivotal role, you will collaborate with a multidisciplinary team of experts in genetics, proteomics, structural biology, and artificial intelligence to address complex biological challenges and develop groundbreaking therapies. This is an exceptional opportunity to apply your expertise in cancer biology to design and implement advanced cellular assays for target validation and compound screening. By joining Rezo at this exciting stage, you will have the opportunity to make a significant impact in a dynamic, collaborative setting.

Mar 30, 2026

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AI Research Engineer at Chai Discovery | San Francisco

ChaiDiscovery

Full-time|On-site|San Francisco office

About Chai DiscoveryAt Chai Discovery, we are pioneering advanced AI models that revolutionize molecular design and the drug discovery process. Our dedicated team is committed to reshaping the landscape of therapeutic development, with the ultimate goal of saving lives.Our founders consist of elite researchers and industry leaders who have made groundbreaking contributions to AI applications in biology. They have co-invented protein language modeling, developed cutting-edge folding algorithms, and created AI solutions adopted by top pharmaceutical firms. We are proud to be backed by prominent investors, including OpenAI, Thrive Capital, Dimension, Conviction, Lachy Groom, and Amplify.About the RoleWe are looking for an AI Research Engineer to collaborate closely with our research scientists in designing, training, evaluating, and optimizing the core models and infrastructure at Chai. Our models are evolving from mere protein structure predictions into real-world therapeutic engineering applications. This is a unique opportunity to advance the field of AI-driven drug design while being part of a passionate team that balances cautious optimism with bold vision.Develop and enhance the infrastructure and tools that support our AI research initiatives.Work alongside AI researchers to explore, implement, and refine emerging research directions.Integrate AI models into production environments, ensuring they are scalable and reliable.About YouThe ideal candidate will have a background in high-performance computing, GPU programming, and AI/ML with large-scale data systems.A Bachelor’s or Master’s degree in Computer Science, Software Engineering, or a related discipline.Proficiency in programming languages such as Python, along with deep learning frameworks like PyTorch.A solid understanding of operating system internals.Familiarity with HPC infrastructure, including Slurm and Kubernetes.Experience in performance engineering and profiling for both CPU and GPU workloads.Proven ability in developing, building, and maintaining extensive ETL pipelines.We OfferInnovative Technology: Engage with cutting-edge technologies that have the potential to redefine therapeutic creation.Exceptional Team: Collaborate with renowned experts at the intersection of AI and biology.

Sep 5, 2024

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Machine Learning Engineer - Discovery Applications

mithrl

Full-time|On-site|San Francisco

ABOUT MITHRLAt Mithrl, we envision a future where innovative medicines are delivered to patients in mere months rather than years, and scientific advancements occur at unparalleled speed.Mithrl is pioneering the development of the world’s first commercially available AI Co-Scientist, a revolutionary discovery engine that swiftly converts complex biological data into actionable insights. Scientists can pose questions in natural language, and Mithrl will provide comprehensive analyses, propose novel targets, formulate hypotheses, and generate patent-ready reports—all in minutes.Our success is evident:Achieved 12X year-over-year revenue growthRecognized by leading biotech firms and major pharmaceutical companies across three continentsFacilitating real breakthroughs from target identification to improved patient outcomes.ABOUT THE ROLEWe are seeking a talented ML Engineer for our Discovery Applications team to create high-level, end-to-end scientific workflows that enhance decision-making within the Mithrl platform. This position focuses on developing the application layer that interacts with our AI Co-Scientist. You will play a crucial role in how scientists uncover biomarkers, validate targets, design experiments, and initiate early discovery programs that lead to IND-enabling studies.A strong understanding of the discovery and preclinical development cycle is essential for this role. You will need to comprehend how research teams transition from early target hypotheses to creating biomarker strategies, hit identification, lead optimization, and preclinical validation. Your applications will directly support decision-making across this continuum and will be utilized by scientists and program teams.Your responsibilities will include designing multi-step workflows that integrate analysis modules, ML models, domain-specific logic, and agentic reasoning into cohesive applications. These applications will encompass biomarker discovery, target identification, target validation, small molecule hit identification and optimization, as well as gene therapy workflows. Furthermore, you will adapt applications to incorporate new data modalities as our platform evolves.

Dec 30, 2025

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Software Engineer, Product at Chai Discovery | San Francisco

ChaiDiscovery

Full-time|On-site|San Francisco office

About Chai DiscoveryChai Discovery is at the forefront of innovation, developing cutting-edge AI models that are revolutionizing the process of drug discovery. Our dedicated team is passionate about reimagining the future of medicine, aiming to save lives through advanced technology.Our founding team comprises distinguished researchers and top-tier professionals from Silicon Valley, who have achieved remarkable milestones in AI for biology. With a history of co-inventing protein language models and creating state-of-the-art algorithms, we are proud to be backed by prestigious investors such as OpenAI, Thrive Capital, and many others.About the RoleAs a Product Engineer, you will play a key role in developing the Chai software platform. This includes creating tools for scientists to query models, visualize molecular structures, and analyze data, all while integrating AI into the workflow. You will collaborate closely with designers, machine learning researchers, and laboratory teams to transform complex scientific processes into repeatable solutions. Your focus will be on delivering reliable, elegant, and practical products, both at the surface level and behind the scenes.With Chai's models evolving from foundational research to real-world therapeutic applications, you have the opportunity to help bring groundbreaking AI-driven drug design solutions to market, working with a team that embraces both meticulousness and visionary optimism.

Jun 30, 2025

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Product Designer at Chai Discovery | San Francisco

ChaiDiscovery

Full-time|On-site|San Francisco office

About Chai DiscoveryChai Discovery is at the forefront of innovation, crafting advanced AI models aimed at revolutionizing molecular design and transforming the landscape of drug discovery. Our dedicated team is passionate about reimagining how new cures are developed, with a vision to save lives.The founding team of Chai comprises distinguished researchers and leading Silicon Valley professionals. Our founders have achieved remarkable milestones in AI for biology, co-inventing protein language modeling, developing cutting-edge folding algorithms, and delivering AI solutions that are now utilized by top-tier pharmaceutical companies. We are proud to be supported by industry-leading investors, including OpenAI, Thrive Capital, Dimension, Conviction, Lachy Groom, and Amplify, among others.About the RoleAs the inaugural Product Designer at Chai, you will integrate pioneering AI models into user-friendly tools that are essential for scientific research. You will oversee the complete design process, encompassing user research, wireframes, high-fidelity mockups, design systems, and dashboards that scientists utilize to interact with models, visualize molecular structures, and analyze data with our AI integrated. Your expertise will drive product clarity, consistency, and user satisfaction in a complex and technical domain.With years of foundational research and development, Chai's models are advancing from protein structure prediction to practical therapeutic applications. This is your opportunity to launch the most sophisticated AI drug design models into the market, collaborating with a team that combines meticulous craftsmanship with a broad vision.

Jun 30, 2025

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Senior Software Engineer - Search and Discovery

Ironclad

Full-time|$180K/yr - $200K/yr|On-site|San Francisco

At Ironclad, we are revolutionizing the way legal agreements are managed with our leading AI contracting platform. We transform contracts into valuable assets, enabling faster processing, immediate insights, and empowering agents to drive projects forward, all while maintaining user control. Ironclad integrates the entire contracting process into a single intelligent platform, giving organizations the visibility they need to remain ahead of the curve. Trusted by pioneering organizations such as OpenAI, the World Health Organization, and the Associated Press, we are committed to accelerating business operations worldwide.Recognized as an industry leader, Ironclad is a proud recipient of accolades like Leader in the Forrester Wave and Gartner Magic Quadrant for Contract Lifecycle Management, a Fortune Great Place to Work, and one of Fast Company’s Most Innovative Workplaces. We have also earned spots on Forbes’ AI 50 and Business Insider’s list of Companies to Bet Your Career On. With backing from top investors including Accel, Y Combinator, Sequoia, BOND, and Franklin Templeton, we’re poised for significant growth. Explore more about us at www.ironcladapp.com or follow us on LinkedIn.Engineering at IroncladAs a Senior Software Engineer specializing in Search and Discovery, you will collaborate across teams to identify business challenges and architect innovative solutions. Your work will enable legal professionals to scale their operations exponentially. We seek forward-thinking engineers who understand UI performance as a fundamental engineering challenge. If you have a passion for optimizing rendering cycles, refining critical path CSS, and creating accessible, top-tier experiences in a collaborative and high-growth environment that values remote flexibility and technical excellence, we invite you to help us reshape the legal industry.Search and Discovery TeamWe believe that 'legal software' should not feel outdated. Our goal is to enhance global business efficiency by providing real-time, actionable contract intelligence. The Search & Discovery team is dedicated to crafting seamless user experiences that surface critical insights through intuitive features and an elegant UI. In this role, you will not just be building components; you'll be designing the entire feature lifecycle, enabling users to visualize, edit, and extract complex legal data instantly, turning extensive document collections into valuable insights.This role entails addressing the significant technical challenges associated with rapid growth, including optimizing UI render cycles for data-intensive workflows.

Jan 12, 2026

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Senior Firmware Automation Engineer

Samsara

Full-time|On-site|San Francisco - SF9

Samsara seeks a Senior Firmware Automation Engineer based in San Francisco (SF9). This position centers on enhancing the process of developing and delivering firmware. Role overview The Senior Firmware Automation Engineer will work with teams throughout the company. The main responsibility is to design and implement automation that improves the quality of firmware releases. Collaboration Close coordination with other groups at Samsara is essential. The role requires understanding the needs of different teams and applying automation solutions that support consistent, reliable firmware delivery.

Apr 28, 2026

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Infrastructure Software Engineer

ChaiDiscovery

Full-time|On-site|San Francisco office

About Chai DiscoveryChai Discovery specializes in developing cutting-edge AI models that revolutionize molecular design and redefine drug discovery processes. Our passionate team is dedicated to transforming the search for new cures and improving lives.Our founding team comprises top researchers and Silicon Valley experts, having achieved significant milestones in AI for biology. With a history of co-inventing protein language modeling and creating advanced folding algorithms, our technology has been embraced by leading pharmaceutical companies. We are proud to be supported by prestigious investors including OpenAI, Thrive Capital, Dimension, Conviction, Lachy Groom, Amplify, and others.About the RoleWe are seeking a dedicated Infrastructure Software Engineer focused on crafting robust, streamlined infrastructure solutions. You will develop the foundational compute and infrastructure systems that support our product offerings, model inference processes, and evaluation frameworks. Collaboration with product engineers, researchers, and our commercial team will be key to your success.You will have experience creating services that developers appreciate, successfully deploying and scaling AI/ML systems in production, and effectively anticipating potential challenges that may hinder the adoption of our platform by leading biopharmaceutical organizations.As Chai's models advance from protein structure prediction into practical therapeutic engineering, this role presents a unique opportunity to bring state-of-the-art AI drug design models to market, working alongside a team that is both detail-oriented and optimistic about the future.About YouYou are motivated by a mission to establish the benchmark for impactful AI technology. We are looking for candidates who possess:Software Experience:A Bachelor’s degree or equivalent experience in Computer Science or a related field.5+ years of experience in building production systems utilizing contemporary tools, collaborating with platform, security, and product teams.A keen ability to foresee infrastructure challenges.Comprehensive ownership of 24/7 infrastructure observability, alerting, and incident response.Experience in both 0-to-1 buildouts and 1-to-n scale-ups, along with a rich repository of best practices and strategies.Communication & Collaboration:A passion for code pair-reviewing, documentation, and knowledge sharing with peers.

Nov 25, 2025

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AI Research Scientist at Chai Discovery | San Francisco

Chai Discovery

Full-time|On-site|San Francisco office

Join Chai Discovery as an AI Research ScientistAt Chai Discovery, we are pioneering the development of advanced AI models aimed at revolutionizing molecule design and transforming drug discovery processes. Our dedicated team is passionate about reimagining how new cures are developed, ultimately aiming to save lives.Founded by a collective of leading researchers and seasoned Silicon Valley operators, our team has achieved groundbreaking milestones in AI applications for biology. Our founders have made significant contributions to protein language modeling and cutting-edge folding algorithms, and have successfully partnered with top pharmaceutical companies to implement AI solutions. We are proud to be supported by prestigious investors such as OpenAI, Thrive Capital, Dimension, Conviction, Lachy Groom, Amplify, and more.Role OverviewAs an AI Research Scientist, you will engage in innovative research focused on computational modeling for biological applications. Our projects extend beyond protein structure prediction into actual therapeutic engineering, offering you the opportunity to advance the field of AI-driven drug design, alongside a team that embodies a balance of critical thinking and optimistic vision.Your ProfileWe are looking for a driven AI Leader with extensive research experience and a commitment to pushing boundaries in therapeutic design. The ideal candidate should possess:Research Expertise:A Ph.D. or equivalent research experience in Machine Learning, Computational Biology, Bioinformatics, Computational Chemistry, or a related discipline.A robust publication record in leading ML or life-science journals (e.g., NeurIPS, ICML, Nature Methods, PLoS Computational Biology, J. Chem. Inf. Model., etc.).Technical Proficiency:Fluency in Python and familiarity with deep learning frameworks.Experience in training and evaluating large models using protein, antibody, or small-molecule datasets, or demonstrable transferable ML skills.Experimental Design & Analysis:Ability to convert scientific inquiries into manageable modeling experiments.Competence in managing extensive biological or chemical datasets, deriving significant metrics, and presenting findings to varied audiences.Collaboration & Communication:A collaborative spirit, eager to work with cross-functional teams including wet-lab scientists, software engineers, and product leaders.

Feb 24, 2026

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Business Development and Partnerships Manager

ChaiDiscovery

Full-time|On-site|San Francisco office

About Chai DiscoveryChai Discovery is at the forefront of revolutionizing drug discovery through advanced AI models, dedicated to designing innovative molecules and transforming the future of healthcare. Our passionate, craft-focused team is committed to reimagining how new cures are identified and developed, ultimately saving lives.Founded by esteemed researchers and accomplished Silicon Valley leaders who have co-invented groundbreaking technologies such as protein language modeling and cutting-edge folding algorithms, Chai has successfully attracted $230 million from top-tier investors, including OpenAI, Thrive, General Catalyst, Oak HC/FT, and Dimension. We believe that small, elite teams can surpass larger competitors by rapidly innovating and iterating.Why Join Us Now?With the recent launch of Chai-2, we are witnessing a swift increase in deal volume and demand. We are seeking a dynamic operator and deal-maker to spearhead high-stakes pharmaceutical partnerships. This pivotal role will involve crafting innovative transaction structures and developing novel intellectual property frameworks for our groundbreaking AI-driven drug discovery platform.Your RoleAs our inaugural Business Development hire, you will report directly to our CEO and be a foundational member of Chai's commercial team. Your contributions will be crucial in shaping the trajectory of our business, showcasing exceptional project management abilities, problem-solving acumen, and a drive for creating mutually beneficial partnerships.Key ResponsibilitiesFoster, manage, and advance all partnership deals. Lead negotiations on business terms and translate our business model and pricing strategy into clear, actionable deal frameworks. Serve as the operational lead, overseeing timelines, workflows, and cross-functional collaboration to ensure deal progression.Engage in the development and oversight of “deal maps” that outline the path of each partnership, pinpointing key decision-making moments, gatekeepers, and anticipated interpersonal, political, and business dynamics.Take ownership of the complete contracting process, including drafting, revisions, internal evaluations, and coordination with external counsel, while ensuring all legal aspects of deals maintain momentum from initial dialogue to closure.Assist in defining and upholding the intellectual property strategy that supports our partnerships.Oversee agreements beyond partnerships, including contracts with CROs and data generation collaborators.Preferred Experience and QualificationsA results-oriented deal operator with a legal background (JD preferred) and proven experience in drafting, reviewing, and advancing complex contracts.Background in business development within the pharmaceutical or biotechnology sectors is highly desirable.

Nov 18, 2025

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Senior Automation Engineer at Parabola | San Francisco

Parabola, Inc.

Full-time|$165K/yr - $195K/yr|On-site|San Francisco, California

About Us:Parabola is an innovative workflow builder that simplifies the process of organizing and transforming complex data from various sources, including PDFs, emails, and spreadsheets. Our goal is to empower forward-thinking teams to automate tasks that they previously believed required manual intervention.Prominent companies such as Brooklinen, On Running, and Flexport rely on Parabola to save countless hours and tackle ambitious projects that once seemed unattainable. Whether it’s reconciling inventory from multiple third-party logistics providers, auditing invoices, or the repetitive task of exporting reports every week, Parabola enables teams to automate these processes without needing engineering resources.We are proudly backed by esteemed investors including OpenView Partners, Matrix Partners, and Thrive Capital.About the Role:As a pivotal member of the Automation Engineering team at Parabola, you will be instrumental in helping our largest and most strategic clients realize the full value of our offerings. Your journey will begin in the sales cycle, where you will collaborate closely with customers and Account Executives to establish success metrics and actionable plans for efficient value delivery. Through a combination of training sessions, interactive workshops, and hands-on support, you will work alongside our Mid-Market and Enterprise clientele to design and implement AI-driven workflows that automate intricate business operations and unveil new efficiencies. Your leadership will guide customers from initial design to successful execution, ensuring that each solution provides sustained impact and value, and that customers enjoy a premier onboarding experience, a smooth transition to our Customer Experience team, and a solid foundation for success with our product.About You:You are passionate about customer success. You empathize with their challenges, share in their victories, and celebrate their “ah-ha!” moments as if they were your own. Possessing a natural talent for solving complex problems, you dive deep into understanding customers’ systems, industries, and internal processes. You are equipped with both soft skills for relationship building and technical skills for troubleshooting APIs, querying databases, prompting advanced AI models, and constructing effective Parabola workflows. Your experience includes managing multiple projects simultaneously and working with Mid-Market and Enterprise clients. Above all, you are enthusiastic, confident, and personable, representing our company with pride and advocating for the customers you support.

Mar 3, 2026

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Software Engineer - Distributed Systems

Achira

Full-time|On-site|San Francisco Office

Why Join Achira?Become part of an exceptional team comprised of scientists, ML researchers, and engineers dedicated to transforming the landscape of drug discovery.Engage with cutting-edge machine learning infrastructure at an unprecedented scale, leveraging extensive computing resources, vast datasets, and ambitious goals.Take ownership of significant projects from conception through to architecture and deployment on large-scale infrastructures.Thrive in a culture that values thoroughness, speed, and a proactive, builder-oriented mindset.About the RoleAt Achira, we are developing state-of-the-art foundation models that address the most complex challenges in simulation for drug discovery and beyond. Our atomistic foundation simulation models (FSMs) serve as comprehensive representations of the physical microcosm, encompassing machine learning interaction potentials (MLIPs), neural network potentials (NNPs), and various generative model classes.We are looking for a Software Engineer who is enthusiastic about distributed computing and its applications in machine learning. You will play a pivotal role in designing and constructing the infrastructure for our ML data generation pipelines, model training, and fine-tuning workflows across large-scale distributed systems.Your expertise will be crucial in ensuring our compute clusters are efficient, observable, cost-effective, and dependable, enabling us to advance the frontiers of ML development. If you are passionate about distributed systems, performance optimization, and cloud cost efficiency, we encourage you to apply.You will be empowered to conceptualize and manage complex workloads across multiple vendors worldwide. Achira's mission revolves around computation, and providing seamless access to our uniquely tailored workloads at the lowest possible cost is critical to our success.

Oct 7, 2025

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Senior Manager / Associate Director of Drug Substance - Hypopara

BridgeBio Pharma, Inc.

Full-time|$175K/yr - $185K/yr|On-site|San Francisco - 1800 Owens

BridgeBio Pharma, Inc. was founded in 2015 to address rare diseases through new treatments. The company unites early-stage academic research and innovative projects within a single financial structure. This model is designed to lower risk and foster scientific creativity, enabling small, specialized teams to move promising medicines forward. The organization focuses on closing care gaps for rare diseases and accelerating therapies for patients with unmet needs. Curiosity and unconventional thinking are encouraged, with an emphasis on challenging established approaches to find better solutions. The ethical use of AI supports the team’s goal to work more clearly, quickly, and effectively. Collaboration is a core value at BridgeBio. The company works closely with respected professionals across the industry, guided by a willingness to ask, "Why not?" and a shared commitment to shaping the future of biopharma.

Apr 22, 2026

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Senior Scientist in Medicinal Chemistry

Olema Oncology

Full-time|$160K/yr - $170K/yr|On-site|San Francisco, California

At Olema Oncology, we are unwavering in our commitment to advancing innovative treatments for breast cancer and beyond. Our flagship candidate, palazestrant (OP-1250), is a groundbreaking complete estrogen receptor antagonist (CERAN) currently being developed for metastatic breast cancer. With the potential to be a market leader, it is designed for use both as a monotherapy and in combination therapies for ER+/HER2- metastatic breast cancer. Additionally, our next candidate, OP-3136, is a powerful KAT6 inhibitor that aims to set a new standard in the field.Our success is fueled by the collaborative spirit that drives our team to support, inspire, and challenge each other. At Olema, we prioritize our people, ensuring that our endeavors yield unparalleled results. If you are eager to be part of a transformative journey, join us as we strive to make a significant difference for our patients, your career, and the future of medicine.You can view our latest corporate deck and other presentations here.About the Role: Senior Scientist, Medicinal ChemistryAs the Senior Scientist in Medicinal Chemistry, you will report directly to the Associate Director of Medicinal Chemistry and play a pivotal role in designing and synthesizing novel small molecules to support our hit-to-lead and lead optimization initiatives. You will collaborate closely with our internal medicinal chemistry team and oversee external resources involved in the development of new small molecule drug candidates. You may also lead the organic chemistry efforts within multidisciplinary project teams, advancing drug discovery projects from inception to clinical trials to fulfill our mission of delivering innovative medicines to cancer patients.This position is based in our San Francisco Bay Area Laboratory and requires approximately 5% travel.Your core responsibilities will include:Executing hit-to-lead and lead optimization by designing and synthesizing novel small molecules.Guiding external chemistry resources through the design of synthetic strategies, target prioritization, and innovative solutions to complex chemistry challenges.Advancing novel small molecule hits and lead compounds into clinical candidates by utilizing structure-based drug design and multi-parameter lead optimization.

Mar 31, 2026

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Senior QA Automation Engineer at Mesh | San Francisco

Mesh

Full-time|$100K/yr - $400K/yr|On-site|San Francisco, CA

Mesh is building technology to make cryptocurrency payments practical for everyday use. The company’s orchestration engine and consumer app help unlock liquidity from tokenized assets, aiming to support global commerce. Mesh is headquartered in San Francisco and operates internationally, with backing from investors including PayPal Ventures, Paradigm, and Galaxy Ventures. Role overview The Senior QA Automation Engineer leads quality engineering across Mesh’s development lifecycle. This position designs and maintains automation frameworks, sets quality standards, and works to embed quality into every stage of product development. Collaboration is key: expect to work closely with engineers, product managers, and designers to deliver reliable Web3 experiences. Teams span North America, Europe, and India. What you will do Design, build, and maintain end-to-end test automation frameworks using tools such as Playwright. Create test strategies that cover the full stack, including UI, APIs, smart contract interactions, and wallet flows. Develop and maintain tests for Web3 user journeys, such as wallet connections, transaction signing, contract interactions, and on-chain state checks. Integrate automated test suites into CI/CD pipelines and monitor their health over time. Use AI-driven development tools (for example, Copilot, Cursor, Claude) to accelerate test writing and framework development, and share best practices with the team. Identify gaps in test coverage, set priorities, and drive ongoing improvement. Promote a culture of quality within engineering. Stay current with new testing tools, frameworks, and developments in the Web3 space. Requirements At least 7 years of experience in QA engineering, with a strong focus on automation. Extensive hands-on experience with Playwright and/or Cypress. Familiarity with other tools such as WebdriverIO, Selenium, or Puppeteer is a plus. Proficiency in automation frameworks and quality assurance best practices (additional technical requirements were not specified in the source). Location This position is based in San Francisco, CA, and involves collaboration with Mesh’s distributed teams.

Apr 24, 2026

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Immediate Opening for Senior Automation Engineer (W2)

360IT Professionals

Full-time|On-site|San Francisco

We are seeking a highly skilled Senior Automation Engineer to join our dynamic team. In this role, you will be responsible for designing, implementing, and maintaining automated testing frameworks and tools that ensure our software products meet the highest quality standards. Your expertise will play a critical role in enhancing our automation processes and driving efficiency across our operations.

Apr 28, 2017

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Software Development Engineer - Automation & Quality Focus

Drivetrain

Full-time|Remote|India

Join Drivetrain, where our mission is to empower businesses to make informed decisions. Our innovative financial planning and decision-making platform enables companies to scale efficiently and meet their targets with confidence.As a remote-first organization based in the San Francisco Bay Area, Drivetrain was founded in 2021 by former Google employees. Our rapidly growing company is supported by prominent venture capital firms, positioning us on a path to success. Embracing Remote Work: We believe in bringing together the brightest minds, regardless of location, and we offer significant autonomy within our teams. We trust our employees to deliver their best work. Transparency Matters: With open access to the information our creators need, we foster an environment where excellence thrives. Fostering Innovation: We encourage a culture where new ideas can flourish, allowing team members to take risks, learn, and contribute to positive change. The best ideas will lead the way. Customer-Centric Approach: Our product-led growth strategy means we consistently learn from our customers to build amazing software.Role OverviewAs a Backend Engineer at Drivetrain, you will be integral to enhancing our engineering productivity through the development and maintenance of high-quality automation frameworks. Your expertise will contribute to identifying bugs, implementing effective solutions, and ensuring our systems operate seamlessly.Your skills in data structures, algorithms, and backend programming will be crucial for delivering optimal performance while maintaining exemplary code quality.

Jul 21, 2024

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Senior Stationary Engineer at the Academy of Sciences

City and County of San Francisco

Full-time|On-site|San Francisco

The Academy of Sciences is seeking a dedicated and skilled Senior Stationary Engineer to join our team. In this pivotal role, you will be responsible for the operation, maintenance, and repair of various heating, cooling, and mechanical systems, ensuring optimal performance and safety standards.Your expertise will contribute significantly to the Academy's mission of promoting scientific education and research. If you are passionate about sustainability and possess a proactive approach to problem-solving, we encourage you to apply.

Aug 31, 2023

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