Staff/Lead Site Reliability Engineer (SRE)

HeartFlow, Inc.San Francisco, California

On-site Full-time $200.8K/yr - $250.9K/yr

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Experience Level

Senior

Qualifications

Job ResponsibilitiesAs the Staff SRE, you will be the principal expert overseeing our entire compute ecosystem. Your core responsibilities will include:Leading the design, implementation, and management of robust, scalable cloud infrastructure. Defining and initiating the rollout of SLI/SLO standards across microservices. Creating self-service instrumentation tools that empower engineering teams to take ownership of observability. Establishing observability and monitoring frameworks using an open-source toolchain. Acting as a technical escalation contact for critical incidents, conducting thorough root cause analyses (RCAs), and implementing corrective actions.

About the job

About HeartFlow

HeartFlow, Inc. is a medical technology company focused on improving the diagnosis and management of coronary artery disease. Our flagship product, the AI-powered HeartFlow FFR_CT Analysis, provides a non-invasive, color-coded 3D view of a patient’s coronary arteries. Clinicians use our platform to identify blockages, assess blood flow, and analyze atherosclerosis, all in alignment with ACC/AHA Chest Pain Guidelines. HeartFlow’s technology supports care teams in the US, UK, Europe, Japan, and Canada, and has already impacted over 500,000 patients worldwide.

As a publicly traded company (NASDAQ: HTFL), HeartFlow continues to expand its product line and modernize its platform to support the next generation of life-saving medical technologies.

Role Overview: Staff/Lead Site Reliability Engineer (SRE)

HeartFlow is searching for an experienced Site Reliability Engineer to join the cloud-native infrastructure team in San Francisco, California. This role works closely with Platform engineers and development teams to maintain and improve the reliability, scalability, observability, and performance of critical systems.

What You Will Do

Collaborate with Platform and development teams to ensure system reliability and performance
Automate complex operational processes and reduce manual work
Establish and promote standards for production excellence
Support ongoing Platform Modernization initiatives

Who We’re Looking For

Extensive experience as a Site Reliability Engineer or in a similar role
Strong background in cloud-native infrastructure
Interest in automation, reliability, and scalable systems
Comfort working with cross-functional engineering teams

Location

This position is based in San Francisco, California.

About HeartFlow, Inc.

HeartFlow, Inc. is at the forefront of cardiovascular care innovation, employing state-of-the-art, non-invasive technology to revolutionize patient diagnostics and treatment. Our commitment to enhancing healthcare outcomes is reflected in our dynamic team and our expanding range of products.

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About HiveHive stands at the forefront of cloud-based AI innovation, providing cutting-edge solutions that enable organizations to understand, search, and generate content. Our platform is relied upon by some of the world's most prestigious and forward-thinking companies. We empower developers with an extensive suite of state-of-the-art, pre-trained AI models that handle billions of API requests each month. In addition to our robust model offerings, we deliver comprehensive software applications backed by proprietary AI models and datasets, unlocking transformative applications in various sectors such as content moderation, brand protection, sponsorship measurement, and context-based advertising.With over $120 million in funding from esteemed investors like General Catalyst, 8VC, Glynn Capital, Bain & Company, and Visa Ventures, Hive has cultivated a vibrant global team of over 250 employees across our San Francisco, Seattle, and Delhi offices. If you’re passionate about shaping the future of AI, we invite you to join our dynamic team!DevOps and Systems TeamIn response to our distinctive machine learning demands, we have developed our own data centers focusing on distributed high-performance computing with GPU integration. While we harness the power of these data centers, our infrastructure remains hybrid, leveraging public cloud solutions when advantageous. As we scale our machine learning models for commercial use, we are expanding our DevOps and Site Reliability team to ensure the reliability of our enterprise SaaS offerings. Our ideal candidate thrives in dynamic environments, embraces automation, and believes that every task can be automated and every server can scale. You take pride in enhancing performance across all layers of our stack and are committed to never performing the same task manually twice.

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Site Reliability Engineer at Mercor | San Francisco

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Full-time|On-site|San Francisco

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Dec 27, 2025

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Site Reliability Engineer at Superhuman | San Francisco

Superhuman, Inc.

Full-time|$214K/yr - $260K/yr|Hybrid|Hub - San Francisco

At Superhuman, we embrace a vibrant hybrid work model that offers our team members the ideal blend of focused individual work and collaborative in-person interactions, fostering trust, innovation, and a robust team culture.About SuperhumanSuperhuman, the AI productivity platform, is on a transformative mission to unlock the superhuman potential within everyone. With the integration of Grammarly's writing assistance and innovative tools like Coda’s collaborative workspaces and Go, our proactive AI assistant, we empower over 40 million individuals and 50,000 organizations globally. Founded in 2009, we strive to eliminate busywork and enhance productivity. Discover more at superhuman.com and explore our values here.The OpportunityTo meet our ambitious goals, we are seeking a Site Reliability Engineer (SRE) to join our infrastructure team. This pivotal role focuses on developing software solutions to maintain the reliability of our back-end systems while collaborating with engineering teams to strategize our future growth. You will also engage with our production engineering teams in Europe as we transition from a “you build it, you own it” approach.At Superhuman, our engineers and researchers enjoy the autonomy to innovate and drive breakthroughs, directly impacting our product roadmap. As we rapidly scale our interfaces, algorithms, and infrastructure, the complexity of our technical challenges is growing. Learn more about our technical endeavors on our technical blog.As an SRE, your responsibilities will include:Scaling our Kubernetes-based control plane that processes billions of events each day.Enhancing our automation mechanisms to efficiently respond to workload demands.Deploying machine learning systems across various departments.

Jun 18, 2025

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Senior Site Reliability Engineer for AI Infrastructure

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Join Andromeda as a Senior Site Reliability Engineer specializing in AI Infrastructure. In this pivotal role, you will be responsible for ensuring the reliability, scalability, and performance of our cutting-edge AI systems. Collaborate with cross-functional teams to design and implement robust infrastructure solutions that support our innovative AI initiatives. Your expertise will play a crucial role in maintaining optimal service availability and improving system performance.

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Staff/Lead Site Reliability Engineer (SRE)

HeartFlow, Inc.

Full-time|$200.8K/yr - $250.9K/yr|On-site|San Francisco, California

About HeartFlow HeartFlow, Inc. is a medical technology company focused on improving the diagnosis and management of coronary artery disease. Our flagship product, the AI-powered HeartFlow FFRCT Analysis, provides a non-invasive, color-coded 3D view of a patient’s coronary arteries. Clinicians use our platform to identify blockages, assess blood flow, and analyze atherosclerosis, all in alignment with ACC/AHA Chest Pain Guidelines. HeartFlow’s technology supports care teams in the US, UK, Europe, Japan, and Canada, and has already impacted over 500,000 patients worldwide. As a publicly traded company (NASDAQ: HTFL), HeartFlow continues to expand its product line and modernize its platform to support the next generation of life-saving medical technologies. Role Overview: Staff/Lead Site Reliability Engineer (SRE) HeartFlow is searching for an experienced Site Reliability Engineer to join the cloud-native infrastructure team in San Francisco, California. This role works closely with Platform engineers and development teams to maintain and improve the reliability, scalability, observability, and performance of critical systems. What You Will Do Collaborate with Platform and development teams to ensure system reliability and performance Automate complex operational processes and reduce manual work Establish and promote standards for production excellence Support ongoing Platform Modernization initiatives Who We’re Looking For Extensive experience as a Site Reliability Engineer or in a similar role Strong background in cloud-native infrastructure Interest in automation, reliability, and scalable systems Comfort working with cross-functional engineering teams Location This position is based in San Francisco, California.

Apr 14, 2026

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Product Infrastructure Engineer - Site Reliability

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Full-time|On-site|San Francisco

Zyphra is a cutting-edge artificial intelligence firm located in the heart of San Francisco, California.The Opportunity:As a Product Infrastructure Engineer specializing in Site Reliability, your primary focus will be on architecting and sustaining the frameworks that ensure Zyphra's infrastructure remains strong, observable, secure, and scalable. Your contributions will be pivotal in guaranteeing the dependability and reproducibility of machine learning workloads, managing deployment safety, and ensuring the long-term viability of our computational environments.Your Responsibilities:Enhancing and developing observability systems (monitoring, logging, alerting)Creating resilient build and deployment systems across both research and production settingsEstablishing secure release protocols with comprehensive audit trails and rollback capabilitiesCollaborating closely with ML engineers, DevOps, and infrastructure teams to optimize system reliability and performanceLeading incident response efforts, conducting root-cause analysis, and facilitating postmortems with a strong emphasis on learning and preventionThis position is perfect for individuals who are passionate about creating systems that empower other teams to be faster, safer, and more efficient.Qualifications:Proven experience in high-performance computing environments, such as machine learning clusters or GPU farmsStrong background in infrastructure as code tools (e.g., Ansible, Terraform)Familiarity with software release engineering tailored for ML/AI systems is advantageousExperience in designing reliable environments for experimental workloads and reproducible executionsUnderstanding of compliance and auditing standards related to deployment and system securityExperience with load testing, fault injection, and chaos engineering to strengthen systems under pressureA passion for developing tools that render infrastructure seamless and reliable for end usersPreferred Qualifications:Experience with infrastructure as code (e.g., Ansible, Terraform)Previous experience supporting ML/AI infrastructure, including GPU management and workload optimizationExposure to backend development for ML model serving (e.g., vLLM, Ray, SGLang)

Aug 22, 2025

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