Staff/Lead Site Reliability Engineer (SRE)

HeartFlow, Inc.San Francisco, California

On-site Full-time $200.8K/yr - $250.9K/yr

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Experience Level

Senior

Qualifications

Job ResponsibilitiesAs the Staff SRE, you will be the principal expert overseeing our entire compute ecosystem. Your core responsibilities will include:Leading the design, implementation, and management of robust, scalable cloud infrastructure. Defining and initiating the rollout of SLI/SLO standards across microservices. Creating self-service instrumentation tools that empower engineering teams to take ownership of observability. Establishing observability and monitoring frameworks using an open-source toolchain. Acting as a technical escalation contact for critical incidents, conducting thorough root cause analyses (RCAs), and implementing corrective actions.

About the job

About HeartFlow

HeartFlow, Inc. is a medical technology company focused on improving the diagnosis and management of coronary artery disease. Our flagship product, the AI-powered HeartFlow FFR_CT Analysis, provides a non-invasive, color-coded 3D view of a patient’s coronary arteries. Clinicians use our platform to identify blockages, assess blood flow, and analyze atherosclerosis, all in alignment with ACC/AHA Chest Pain Guidelines. HeartFlow’s technology supports care teams in the US, UK, Europe, Japan, and Canada, and has already impacted over 500,000 patients worldwide.

As a publicly traded company (NASDAQ: HTFL), HeartFlow continues to expand its product line and modernize its platform to support the next generation of life-saving medical technologies.

Role Overview: Staff/Lead Site Reliability Engineer (SRE)

HeartFlow is searching for an experienced Site Reliability Engineer to join the cloud-native infrastructure team in San Francisco, California. This role works closely with Platform engineers and development teams to maintain and improve the reliability, scalability, observability, and performance of critical systems.

What You Will Do

Collaborate with Platform and development teams to ensure system reliability and performance
Automate complex operational processes and reduce manual work
Establish and promote standards for production excellence
Support ongoing Platform Modernization initiatives

Who We’re Looking For

Extensive experience as a Site Reliability Engineer or in a similar role
Strong background in cloud-native infrastructure
Interest in automation, reliability, and scalable systems
Comfort working with cross-functional engineering teams

Location

This position is based in San Francisco, California.

About HeartFlow, Inc.

HeartFlow, Inc. is at the forefront of cardiovascular care innovation, employing state-of-the-art, non-invasive technology to revolutionize patient diagnostics and treatment. Our commitment to enhancing healthcare outcomes is reflected in our dynamic team and our expanding range of products.

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Full-time|$170K/yr - $230K/yr|On-site|San Francisco Bay Area

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Crusoe

Full-time|$172K/yr - $209K/yr|On-site|San Francisco, CA - US

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Site Reliability Engineer at Blaxel | San Francisco

Blaxel

Full-time|On-site|San Francisco

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Mar 3, 2026

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Site Reliability Engineer (SRE) at Mithril | San Francisco

Mithril

Full-time|$170K/yr - $230K/yr|On-site|Palo Alto / San Francisco Bay Area

Mithril develops AI infrastructure aimed at making GPU computing more accessible and affordable for enterprises, AI startups, and researchers. Clients include LG AI Research, Saronic, and the Broad Institute. The company was founded by a former Google DeepMind research scientist and a Stanford CS PhD. Mithril has secured $80M in seed and Series A funding from Sequoia Capital and Lightspeed Venture Partners. Over the past year, platform revenue has grown more than sixfold. Fast Company recognized Mithril as the 8th Most Innovative Company in Artificial Intelligence for 2026. The engineering team at Mithril is small, with each member making a significant impact. This Site Reliability Engineer (SRE) position is a foundational role focused on shaping how the platform scales across a multi-cloud environment. Role overview This SRE will play a central role in keeping Mithril's global GPU orchestration platform stable and high-performing. The responsibilities extend beyond day-to-day maintenance. The primary focus is on designing and building automation, observability, and tooling to help manage advanced compute resources across multiple cloud providers. The goal is to ensure customers have fast and dependable access to infrastructure. Collaboration with Mithril's founding team is central to this job. The SRE will help set service level objectives (SLOs), orchestrate capacity, and make influential infrastructure decisions, gaining visibility into both technical and commercial aspects of the business. What makes this SRE role unique This position differs from many early-stage SRE roles that focus mainly on on-call rotations and incident response. Here, the emphasis is on building infrastructure that actively shapes Mithril's marketplace. The systems developed will determine how supply is sourced, allocated, and monitored across providers, directly affecting customer experience and company revenue. The role offers genuine ownership, a fast feedback loop with leadership, and the opportunity to define how infrastructure engineering evolves as Mithril grows. Core responsibilities About 70–75% of the work centers on platform reliability and infrastructure automation. Reliability & SLOs Implement and manage service level indicators (SLIs) and service level objectives (SLOs) for Mithril's API layer and internal orchestration services to maintain high reliability and performance.

Apr 22, 2026

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Site Reliability Engineer

Cognition

Full-time|On-site|San Francisco Bay Area

Join Our TeamAt Cognition, we are at the forefront of applied AI innovation, developing cutting-edge software agents that redefine the engineering landscape. Our flagship products, Devin, the pioneering AI software engineer, and Windsurf, an AI-native IDE, embody our commitment to creating AI that collaborates with engineers as a true partner.Our team is composed of elite talent including competitive programming champions, visionary founders, and researchers from top AI institutions such as Scale AI, Palantir, Cursor, Google DeepMind, and more.Your MissionAs a Site Reliability Engineer, you will play a crucial role in ensuring the reliability of our user-focused products, which are utilized by hundreds of thousands of developers daily. Your mission is to preemptively address potential issues and swiftly resolve any incidents that may arise, maintaining a seamless experience for our users.You will be responsible for overseeing production reliability and enhancing our platform engineering practices, encompassing SLOs, incident response, and on-call duties, alongside CI/CD pipelines, deployment infrastructure, and developer tools. At Cognition, we believe in integrating reliability into our systems rather than treating it as an afterthought, and we strive to cultivate a culture that reflects this philosophy.Your AchievementsProduction Reliability: Establish and manage SLOs, SLIs, and error budgets for our products. Develop robust monitoring, alerting, and observability systems to maintain a transparent view of service health.Incident Management: Spearhead incident response with precision and promptness. Conduct blameless postmortems to derive actionable insights from outages, and create effective runbooks and tools to enhance on-call sustainability.Platform Engineering: Oversee deployment pipelines and internal developer tools, ensuring rapid, reliable shipping of code while minimizing unnecessary toil for engineers.Infrastructure as Code: Manage cloud infrastructure via code, creating reproducible, auditable environments that can scale with product demands and mitigate configuration drift.Capacity Planning: Analyze growth trends, anticipate resource requirements, and ensure our infrastructure is always ahead of user demand, optimizing system performance proactively.Security and Reliability: Integrate security protocols with reliability practices to create a robust framework that safeguards our infrastructure.

Oct 13, 2025

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Site Reliability Engineer, Frontier Systems Infrastructure

OpenAI

Full-time|On-site|San Francisco

About Our TeamThe Frontier Systems team at OpenAI is at the forefront of technological innovation, responsible for designing, deploying, and maintaining state-of-the-art supercomputers that power our most advanced model training initiatives. We transform innovative data center designs into fully functional systems and develop the necessary software to support extensive frontier model training.Our mission is to ensure the stability and efficiency of these hyperscale supercomputers, providing an uninterrupted environment for the training of frontier models.About the OpportunityWe are seeking passionate engineers to manage the next generation of compute clusters that fuel OpenAI’s leading-edge research. This role merges distributed systems engineering with practical infrastructure expertise across our expansive data centers. You will be tasked with scaling Kubernetes clusters to unprecedented levels, automating bare-metal deployments, and creating software solutions that simplify interactions across a multitude of nodes in various data centers.You will operate at the confluence of hardware and software, where speed and reliability are of utmost importance. Prepare to oversee dynamic operations, swiftly diagnose and resolve critical issues, and continuously enhance automation and system uptime.Key Responsibilities:Deploy and scale substantial Kubernetes clusters, implementing automation for provisioning, bootstrapping, and lifecycle management.Create software abstractions that integrate multiple clusters, delivering a seamless interface for training workloads.Oversee node deployment from bare metal to firmware upgrades, ensuring swift and repeatable processes at scale.Enhance operational metrics, striving to minimize cluster restart times (e.g., reducing from hours to minutes) and expedite firmware or OS upgrades.Integrate networking and hardware health systems to ensure comprehensive reliability across servers, switches, and data center infrastructure.Develop monitoring and observability systems that proactively identify issues and maintain cluster stability under peak loads.Be prepared to perform at the level of a software engineer in execution and problem-solving.You May Be a Great Fit If You:Possess extensive experience in operating or scaling Kubernetes clusters or similar container orchestration systems.

Nov 3, 2025

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Senior Site Reliability Engineer

alembic

Full-time|On-site|San Francisco HQ

About the RoleJoin alembic as a Senior Site Reliability Engineer (SRE) and become an integral part of our mission to enhance platform reliability, observability, and operational excellence. In this pivotal role, you will collaborate with engineers and data scientists to architect, automate, and maintain the robust infrastructure that drives our platform, including data pipelines, machine learning workloads, and real-time analytics systems.This hands-on position offers significant visibility across the technology stack and provides you with the opportunity to shape the future of our infrastructure and operations.

Dec 22, 2025

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Senior Site Reliability Engineer

Hive

Full-time|On-site|San Francisco

About HiveHive stands at the forefront of cloud-based AI innovation, providing cutting-edge solutions that enable organizations to understand, search, and generate content. Our platform is relied upon by some of the world's most prestigious and forward-thinking companies. We empower developers with an extensive suite of state-of-the-art, pre-trained AI models that handle billions of API requests each month. In addition to our robust model offerings, we deliver comprehensive software applications backed by proprietary AI models and datasets, unlocking transformative applications in various sectors such as content moderation, brand protection, sponsorship measurement, and context-based advertising.With over $120 million in funding from esteemed investors like General Catalyst, 8VC, Glynn Capital, Bain & Company, and Visa Ventures, Hive has cultivated a vibrant global team of over 250 employees across our San Francisco, Seattle, and Delhi offices. If you’re passionate about shaping the future of AI, we invite you to join our dynamic team!DevOps and Systems TeamIn response to our distinctive machine learning demands, we have developed our own data centers focusing on distributed high-performance computing with GPU integration. While we harness the power of these data centers, our infrastructure remains hybrid, leveraging public cloud solutions when advantageous. As we scale our machine learning models for commercial use, we are expanding our DevOps and Site Reliability team to ensure the reliability of our enterprise SaaS offerings. Our ideal candidate thrives in dynamic environments, embraces automation, and believes that every task can be automated and every server can scale. You take pride in enhancing performance across all layers of our stack and are committed to never performing the same task manually twice.

Apr 20, 2022

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Infrastructure & Site Reliability Engineer at Atomic Semi | San Francisco

Atomic Semi

Full-time|$125K/yr - $195K/yr|On-site|San Francisco Office

About Atomic SemiAtomic Semi is pioneering the development of a compact and agile semiconductor fabrication facility.With today’s technology, alongside a few innovative simplifications, we are capable of realizing this vision. We will create our own tools, allowing for rapid iterations and enhancements.Our goal is to assemble a small, exceptional team of hands-on engineers to drive this initiative forward. Our team is composed of experts in mechanical, electrical, hardware, computer, and process engineering. We will manage the entire stack, from atoms to architecture, with a forward-thinking approach that pushes the boundaries of technology.Our philosophy emphasizes that smaller, faster, and self-built systems are superior.We are confident that our team and lab can create anything we envision. Equipped with 3D printers, diverse microscopes, e-beam writers, and general fabrication tools, we are committed to inventing whatever tools we may need along the way.Founded by Sam Zeloof and Jim Keller, Atomic Semi combines Sam's garage chip-making prowess with Jim's extensive 40-year leadership in the semiconductor industry.About the RoleWe are in search of an Infrastructure & Site Reliability Engineer to design, construct, deploy, and oversee the on-premises backend infrastructure that drives our rapid semiconductor fabrication process.This multifaceted role encompasses all elements of backend infrastructure and services.Our infrastructure philosophy prioritizes minimalism, clarity, on-site operations, and proximity to hardware. Expect a focus on bare-metal Linux, systemd, and single-file binaries rather than extensive use of Docker, cloud services, or Kubernetes. Proficiency in Rust, Go, and Python will be beneficial.We welcome candidates from various experience levels—ranging from outstanding early-career engineers to seasoned professionals. We are not fixed on a specific background; what is paramount is your proven ability to build real systems, enthusiasm for hands-on engineering, and a strong display of engineering excellence. If you are passionate about performance engineering, developing complex features from the ground up, and swiftly mastering new domains, this is an exciting opportunity for you.A portfolio or GitHub account is generally required to apply: demonstrate the projects you’ve undertaken!

Feb 13, 2026

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Staff/Lead Site Reliability Engineer (SRE)

HeartFlow, Inc.

Full-time|$200.8K/yr - $250.9K/yr|On-site|San Francisco, California

About HeartFlow HeartFlow, Inc. is a medical technology company focused on improving the diagnosis and management of coronary artery disease. Our flagship product, the AI-powered HeartFlow FFRCT Analysis, provides a non-invasive, color-coded 3D view of a patient’s coronary arteries. Clinicians use our platform to identify blockages, assess blood flow, and analyze atherosclerosis, all in alignment with ACC/AHA Chest Pain Guidelines. HeartFlow’s technology supports care teams in the US, UK, Europe, Japan, and Canada, and has already impacted over 500,000 patients worldwide. As a publicly traded company (NASDAQ: HTFL), HeartFlow continues to expand its product line and modernize its platform to support the next generation of life-saving medical technologies. Role Overview: Staff/Lead Site Reliability Engineer (SRE) HeartFlow is searching for an experienced Site Reliability Engineer to join the cloud-native infrastructure team in San Francisco, California. This role works closely with Platform engineers and development teams to maintain and improve the reliability, scalability, observability, and performance of critical systems. What You Will Do Collaborate with Platform and development teams to ensure system reliability and performance Automate complex operational processes and reduce manual work Establish and promote standards for production excellence Support ongoing Platform Modernization initiatives Who We’re Looking For Extensive experience as a Site Reliability Engineer or in a similar role Strong background in cloud-native infrastructure Interest in automation, reliability, and scalable systems Comfort working with cross-functional engineering teams Location This position is based in San Francisco, California.

Apr 14, 2026

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