Technical Program Manager - Ground Systems and Operations

At Alumis Inc., we are dedicated to revolutionizing the treatment of autoimmune diseases through precision medicine. Despite advancements in treatment over the past two decades, many patients with immunologic conditions still endure significant challenges. Our mission is to fundamentally improve the health outcomes for these individuals.We are on the lookout…

Join Alector as the Senior Director of CMC Technical Operations, where you will lead innovative efforts in the development of siRNA therapeutics. This pivotal role involves overseeing the entire lifecycle of CMC activities, ensuring regulatory compliance, and driving the strategic direction of our product pipeline. Your expertise will be instrumental in collaborating with cross-functional teams to advance our mission of harnessing the power of RNA therapeutics.

Join Our Vision at insitroinsitro is on the hunt for a dynamic Senior Director of External Research & Development to spearhead all facets of our external R&D portfolio. This pivotal leadership role is accountable for crafting and executing the company’s external R&D strategy, defining and optimizing our collaborations with preclinical and research contract research organizations (CROs).In this strategic capacity, you will work closely with senior leaders across diverse functions, including Research, Drug Discovery, Technical Operations, Corporate Development & Strategy, Finance, and Project Management, ensuring a seamless approach to alliance and outsourcing management.Reporting directly to the Chief Technical Operations Officer, this position welcomes both remote and local candidates, offering flexibility to work onsite (3 days per week) at our South San Francisco office or a hybrid model (~1 week per month) with some travel (up to 25%) to oversee partnerships both domestically and internationally.Key ResponsibilitiesExternal R&D Strategy: Drive a comprehensive external research strategy, aligning with corporate objectives and supporting the research portfolio. Represent insitro in senior-level partnership discussions and negotiations, ensuring effective management of business partnerships.Partner Network Management: Cultivate and oversee innovative relationships with a strategic network of high-quality CROs and external partners, maintaining the highest scientific and ethical standards.Project Execution & Oversight: Ensure the successful planning, monitoring, and execution of externally sourced projects across the vendor network, adhering to project goals, budgets, and timelines. Foster strong communication and partnership with internal stakeholders.Governance & Compliance: Develop effective governance models and collaborate with Legal and Procurement on partner selection, negotiations, and agreement execution.Process & Team Leadership: Lead a team to implement industry-leading processes in vendor management, ensuring compliance with contractual obligations and standard operating procedures (SOPs).Operational Review & Improvement: Regularly assess the overall scope of outsourced services to ensure resource efficiency and effectiveness.

Join Alumis Inc., a pioneering precision medicines company dedicated to transforming the lives of patients with autoimmune diseases. Despite substantial advancements in treatment over the past two decades, many individuals with immunologic conditions continue to face challenges. Our mission is to fundamentally improve outcomes for these patients.The Senior Manager of Pharmacovigilance (PV) Safety Operations will report to the Director of PV Safety Operations. This pivotal position is essential for ensuring the timely reporting, processing, and submission of Individual Case Safety Reports (ICSRs) originating from ongoing clinical trials and post-marketing studies. The role encompasses oversight of case processing vendors, management of the ICSR process, collaboration with cross-functional teams during study execution, and support for inspection readiness activities, all while ensuring strict compliance with regulatory requirements.

About Us Kardigan is a pioneering company dedicated to transforming heart health by making cardiovascular diseases preventable and curable, striving to eliminate it as the leading cause of death globally.Our mission is to develop multiple targeted therapies in parallel, ensuring that individuals suffering from cardiovascular diseases have access to the cures they deserve. Founded by renowned experts Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan is backed by a legacy of success from their work at MyoKardia, where they played pivotal roles in the discovery and development of mavacamten, the first cardiac myosin inhibitor, which led to its acquisition by Bristol Myers Squibb in 2020. We boast an advanced discovery and translational research platform, a robust pipeline of late-stage candidates, and an exceptional team committed to enhancing patient lives. At Kardigan, our values shape our interactions and drive our success. We are patient-focused, prioritizing the needs of patients and their families. Our commitment to authenticity fosters an inclusive environment where everyone is valued. With an eagerness to learn, we encourage curiosity and adaptability. We believe in team success, striving for excellence, and supporting each other in our roles. Finally, we aim to enable the impossible, embracing risks to spur innovation and advance scientific breakthroughs. These guiding principles empower us to make a tangible difference every day.

Join Kardigan as a Senior Manager of Statistical Programming, where you will lead a dynamic team of statistical programmers to deliver innovative data solutions in clinical research. You will be responsible for overseeing programming activities, ensuring compliance with regulatory standards, and providing mentorship to junior staff.In this role, you will work closely with cross-functional teams to interpret complex data and translate it into actionable insights. Your expertise will drive the development of statistical analysis plans and programming specifications, contributing to the advancement of groundbreaking therapies.

Join Xaira Therapeutics as a Senior Research Associate Scientist specializing in Display Technologies. In this pivotal role, you will be at the forefront of groundbreaking research and development initiatives that are shaping the future of therapeutic solutions. Your expertise will directly contribute to the innovation of our display technology, enhancing our product offerings and impacting the lives of patients worldwide.

About PhyloPhylo is a pioneering applied research laboratory dedicated to the advancement of agentic intelligence aimed at accelerating the discovery process for biomedical scientists. We envision a future where AI agents revolutionize biomedical research, fostering rapid and systematic scientific advancements.Our expanding team consists of elite researchers and engineers specializing in AI and biology. With a robust $13.5M seed funding round led by top-tier investors such as a16z, Menlo Ventures, and Anthropic, and endorsed by Nobel Prize winners and leading biologists, Phylo is at the forefront of developing next-generation AI systems for the life sciences.About the RoleWe are seeking a skilled engineer to construct and maintain the essential systems that drive Phylo’s agentic AI platform in live environments. You will architect and implement distributed systems, computing frameworks, and service architectures that ensure our AI agents operate reliably at scale, whether in cloud-native settings or enterprise environments.This position represents a foundational role within our team, granting you substantial ownership over critical infrastructure decisions, a high level of autonomy, and the opportunity to significantly influence the company’s trajectory from day one.Our engineering team is AI-driven, leveraging coding agents extensively, moving swiftly, and maintaining rigorous standards of engineering excellence.ResponsibilitiesDesign and develop production systems that orchestrate agent execution and support AI-driven scientific workloads.Construct and manage scalable, reliable infrastructure across cloud, hybrid, and on-premises enterprise environments.Oversee enterprise deployment architecture, ensuring secure, reproducible installations for customer-managed infrastructures (VPC, private cloud, on-prem, air-gapped, or regulated environments).Create systems for sandboxed execution, secure task isolation, and controlled computing environments. Design and implement foundational security, access control, and compliance mechanisms suitable for enterprise deployments.Collaborate closely with ML and scientific teams to convert computational workflows into robust, production-grade distributed systems.RequirementsA minimum of 3 years of industry experience in backend, infrastructure, or distributed systems engineering.Demonstrated proficiency in at least one programming language (e.g., Python, Go, Rust).

Role overview phylo seeks a Computational Biology Technical Staff Member based in South San Francisco. This role centers on using computational approaches to address complex biological problems. The position supports projects designed to deepen scientific knowledge and develop practical applications within the field. Responsibilities Apply computational techniques to analyze biological data Work closely with a team of specialists on research and development projects Help advance efforts aimed at solving important challenges in biology Team environment Work alongside experienced professionals committed to advancing the scientific community through computational biology.

About Us:Calico Life Sciences LLC, a pioneering research and development firm established by Alphabet, is dedicated to exploring advanced technologies and model systems that deepen our understanding of the biological mechanisms governing human aging. Our mission is to leverage this knowledge to create interventions that promote longer and healthier lives. With a state-of-the-art technology lab and a commitment to curiosity-driven scientific inquiry, Calico, in partnership with academic and industry leaders, is a vibrant nexus for medical innovation and drug development.Position Overview:We are on the lookout for a passionate and seasoned Principal Investigator in Cardiovascular Research to spearhead laboratory studies and drug development initiatives focused on cardiovascular diseases associated with aging. This pivotal role encompasses the design and execution of research strategies aimed at identifying and validating novel drug targets for age-related cardiovascular conditions. The ideal candidate will possess a robust background in cardiovascular biology, aging research, target identification and validation, and drug discovery methodologies. Proficiency in both in vivo and in vitro models of cardiovascular disease and aging is highly advantageous. This position presents a unique opportunity to directly influence the development of therapeutics designed to enhance cardiovascular healthspan.

About PhyloPhylo is a pioneering applied research laboratory dedicated to harnessing agentic intelligence, revolutionizing the discovery process for biomedical scientists. We envision a future where AI agents transform the landscape of biomedical research. Our rapidly expanding team comprises skilled researchers and engineers specializing in AI and biology.About the RoleWe are seeking a Product Engineer to enhance and scale the foundational product experiences of Phylo's AI agent platform. This multifaceted, full-stack position leans towards frontend development and aims to convert cutting-edge agentic research into fast, reliable, and enjoyable products utilized by real scientists.You will take ownership of product features from start to finish — encompassing UI and interaction design, backend APIs, billing, authentication, and integrations. Collaborating closely with AI researchers, scientists, and infrastructure engineers, you will deliver production-grade systems promptly while maintaining high standards of quality.This role demands a deep interdisciplinary approach. You will spend significant time listening, questioning, and facilitating communication between scientists, product managers, engineering teams, and AI research. As an AI-native engineering team, we leverage coding agents extensively, operate at a fast pace, and uphold a rigorous standard of engineering excellence.Key ResponsibilitiesDevelop and manage full-stack product features across the Phylo platform, from user-facing UI to backend services.Design and implement frontend-heavy experiences for engaging with AI agents, workflows, and scientific tools.Oversee essential product components such as billing, usage tracking, authentication, permissions, and account management.Collaborate intimately with scientists, AI researchers, and engineers to translate capabilities into user-friendly, production-ready product features.Deliver swiftly, iterate based on user feedback, and continuously enhance product quality, reliability, and performance.RequirementsA minimum of 2 years of industry experience as a product, full-stack, or frontend-focused software engineer.Extensive experience in developing modern web applications (e.g., React, TypeScript, or similar frameworks).Proficient in working across the technology stack (frontend, backend, and infrastructure) with excellent communication skills to collaborate effectively across biology, product, engineering, and AI teams.Demonstrated product instincts — a strong passion for user experience, attention to detail, and understanding of how real users interact with products.

About Us:Calico Life Sciences LLC, a forward-thinking research and development company established by Alphabet, is dedicated to unraveling the complexities of human aging through innovative technologies and model systems. Our mission is to deepen understanding of the biology underlying aging, enabling us to create interventions that promote longer, healthier lives. Our state-of-the-art laboratories, commitment to groundbreaking discovery science, and robust pipeline of drug development in collaboration with academic and industry partners, make Calico an inspiring environment for driving medical advancements.Role Overview:We are on the lookout for a dynamic and experienced Director of Research to oversee our early discovery research team comprising talented Principal Investigators and their lab teams. This pivotal role will involve shaping research strategies, assessing research outcomes, and propelling our early-stage drug discovery initiatives aimed at enhancing healthspan through the development of new therapies for aging and age-related conditions. We are particularly interested in candidates with expertise in advanced biochemical, molecular, and cellular biological methodologies, including but not limited to microscopy and omics technologies, to dissect the intricacies of aging biology. A strong background in transitioning projects from early discovery to translational drug development is essential.Join our collaborative and cross-disciplinary team at the forefront of aging research, partner with world-class technology laboratories, spearhead ambitious research initiatives that redefine our understanding of aging, and innovate therapeutics for aging and age-associated diseases.

About ZiplineZipline is the leading global provider of drone delivery services, dedicated to ensuring equitable access to essential goods such as food, medicine, and supplies, whenever and wherever they are needed. We operate the largest autonomous logistics system in the world, executing deliveries with remarkable speed and reliability. Currently, Zipline's services span four continents, achieving a new delivery every 30 seconds, and we have successfully completed millions of deliveries, including critical items like blood, vaccines, and medical supplies.Our clientele comprises the most prominent healthcare systems, governments, and businesses worldwide, all of whom depend on us to save lives, minimize emissions, and enhance economic opportunities through rapid and efficient logistics solutions. Our innovative approach to supply chain management enhances efficiency and reduces congestion, allowing people to reclaim valuable time.We are on a mission to redefine access to healthcare and consumer products globally, having flown over 140 million commercial autonomous miles safely. We seek practical problem solvers who thrive in dynamic environments and are passionate about creating impactful solutions in logistics.About You and The Role As a Senior Logistics Operator at Zipline, you will take charge of outbound logistics operations at our South San Francisco facility. Your primary responsibility will be to ensure the efficient distribution and fulfillment of finished goods and spare parts, supporting both commercial deployments and testing operations.You will play a pivotal role in Zipline's physical supply chain, overseeing daily outbound logistics while enhancing the systems and processes that facilitate scalability. You should be adept at navigating uncertainty, anticipating downstream impacts, and driving results with minimal supervision.Your responsibilities will encompass managing outbound distribution performance metrics, including on-time shipment, fulfillment accuracy, lead times, and cost efficiency to guarantee high-quality outcomes for both internal teams and external customers.

Role Overview Cellares is seeking a Senior Operational Technology Engineer in South San Francisco, CA. This role focuses on strengthening and improving operational technology systems across the company. What You Will Do Work closely with teams from different departments to improve operational systems. Apply technical knowledge to boost the efficiency and reliability of technology supporting operations. Help identify and implement solutions that improve overall performance and support operational goals.

About ZiplineZipline stands as the world's foremost and most experienced drone delivery service, committed to fulfilling our mission of equitable access to food, medicine, and essential goods at any time and in any location. We design, build, and operate an unparalleled autonomous logistics system, ensuring the rapid and reliable delivery of critical supplies. Currently, Zipline operates across four continents, achieving a delivery every 30 seconds and has successfully completed millions of deliveries including blood, vaccines, medical supplies, food, and retail products.Our clientele includes some of the largest and most distinguished healthcare systems, governments, retailers, restaurants, and global enterprises that depend on us to save lives, reduce emissions, enhance economic opportunities, and expedite delivery from point A to point B.Our advanced system strengthens supply chains, alleviates congestion, and saves valuable time for individuals. With over 140 million commercial autonomous miles flown safely, Zipline is revolutionizing access to healthcare, consumer products, and food worldwide.We operate on a global scale and are in search of practical problem solvers who excel in real-world challenges and thrive in a fast-paced environment. Our team is driven by a mission to build systems that have a tangible and meaningful impact on people's lives while scaling the future of logistics. We value individuals who think from first principles, welcome adversity, and can achieve the extraordinary at record speeds.About You and the RoleThe Ground Systems team is a multidisciplinary unit responsible for the design and deployment of the infrastructure that facilitates aircraft charging, package loading, and autonomous operations, which are integral to Zipline's drone delivery network.Within the Ground Systems, the Towers team is dedicated to developing the structural and electrical backbone of Zipline's charging sites. These towers support docks, aircraft operations, power and data distribution, and auxiliary systems across diverse geographies and environmental conditions.As the Technical Program Manager for Towers, you will spearhead the development and deployment of intricate hardware systems...

We are seeking an innovative and strategic Operations Manager for Special Projects to join our dynamic team at Stripe. This exciting role involves overseeing a variety of special projects that drive operational excellence and promote the growth of our services. You will collaborate with cross-functional teams to identify opportunities for improvement, streamline processes, and implement effective solutions.The ideal candidate will possess exceptional leadership skills, a strong analytical mindset, and a passion for driving results in a fast-paced environment. If you thrive on challenges and have a track record of successful project management, we want to hear from you!

At Alumis Inc., we are at the forefront of precision medicine, dedicated to revolutionizing the lives of individuals suffering from autoimmune diseases. Despite significant advancements in treatment over the past two decades, many patients continue to experience hardships. Our mission is to fundamentally transform patient outcomes through innovative solutions.We are currently in search of a dynamic and results-oriented Senior Director of Trade Operations. This pivotal leader will be responsible for the vision, design, and execution of U.S. trade and distribution strategies specifically for our dermatology and immunology product lines. This position is essential in establishing efficient and scalable pathways that enhance product accessibility for patients and healthcare providers.Reporting directly to the Senior Vice President of Market Access, the successful candidate will join a dedicated commercialization team focused on impactful results. Ideal applicants will possess a strategic mindset, thrive in fast-paced environments, and have a demonstrated ability to develop and implement strategies while being deeply engaged in the execution process.

About KardiganKardigan is dedicated to transforming heart health by making cardiovascular disease preventable and curable, aiming to eliminate it as the leading cause of death worldwide.Our mission is to develop a range of targeted treatments simultaneously, ensuring individuals with cardiovascular diseases receive the cures they rightfully deserve. Founded by industry leaders Tassos Giannakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan has built on their successful track record, including the development of mavacamten, the first cardiac myosin inhibitor, which led to an acquisition by Bristol Myers Squibb in 2020. With an advanced discovery and translational research platform, a robust pipeline of late-stage candidates, and a top-tier team, we are committed to enhancing patient lives. Our core values shape our work culture: we are driven by the needs of patients and their families, committed to authenticity, eager to learn, dedicated to teamwork, and unafraid to pursue innovative solutions that may seem impossible. These principles empower us to make a meaningful impact every day. Position OverviewKardigan is looking for a Senior Manager, Clinical Trial Lead to oversee one of our cardiovascular clinical studies. As a Clinical Trial Lead (CTL), you will be integral to our Clinical Operations team, reporting to the Clinical Operations Program Leader (COPL). The CTL will manage trials at a global level, ensuring effective execution across multiple regions.

Join Veracyte, a leader in transforming cancer care through innovative diagnostics that empower patients and clinicians alike. At Veracyte, we provide an inspiring work environment where you can make a significant impact on patients' lives while advancing your career. Our culture, known as the Veracyte way, emphasizes collaboration, resilience, and a commitment to excellence.Our Core Values:We Seek A Better Way: We boldly innovate and learn from challenges to improve cancer care.We Make It Happen: We prioritize urgency, quality, and enjoyment in our work.We Are Stronger Together: We foster open collaboration and celebrate our collective successes.We Care Deeply: We honor our diverse backgrounds and support each other in doing what is right.The Role:We are on the lookout for an enthusiastic Bioinformatics Research Scientist to join our Translational Bioinformatics group within the Bioinformatics and Data Science Team. This pivotal role involves leveraging computational and statistical techniques on extensive transcriptomic and genomic datasets, particularly focusing on prostate cancer biology and its clinical implications. The ideal candidate will play a key role in identifying clinically relevant molecular signatures that enhance disease stratification, prognosis, and the development of diagnostics, while effectively communicating findings to both scientific and clinical audiences. This position offers a unique opportunity to bridge the realms of data science, biology, and clinical research through close collaboration with scientists, clinicians, and cross-functional teams to convert complex data into actionable insights.