Game Engine Engineer

Location: Cambridge, UK – This position offers flexible working options, including predominantly remote work. Applicants should be based (or willing to relocate) within a comfortable commuting distance of our office to attend onsite as required.Join us to work on the foundational technologies that drive the RuneScape franchise and contribute to the evolution…

The Opportunity: Join Relay Therapeutics as a Senior Medical Director, where you will be pivotal in propelling our clinical pipeline from IND to proof of concept and ultimately to registration. In this role, you will partner with senior medical staff to shape clinical strategies, design clinical trials, and ensure successful execution. Collaborating across various functions including clinical project management, regulatory affairs, clinical operations, biostatistics, data management, and medical writing, you will significantly contribute as Relay Therapeutics continues to advance product candidates into clinical settings. You will provide clinical leadership to R&D teams and closely collaborate with Development leadership. We are open to remote employees

The Computational Policy Lab at the Shorenstein Center at Harvard Kennedy School is on the lookout for a Senior Software Engineer with deep expertise in software development, generative AI, and data science. This role is embedded within the Shorenstein Center, which focuses on critical areas of inquiry at the intersection of media, politics, and public policy. As part of our team, you will play a vital role in advancing teaching and research initiatives that strive to make a meaningful impact.Application RequirementsTo be considered, applications must include:A detailed resumeA cover letter that includes:A link to a code sample on GitHub that showcases your technical abilities, ideally a project you would enjoy discussing in an interviewA brief description of the linked projectVerification of your legal authorization to work in the United States without sponsorship for a minimum of two yearsJob-Specific Responsibilities:Your main duties will include:Independently managing complex applications/web development for large-scale projectsDesigning and implementing sophisticated software systems geared towards large-scale research projects, focusing on educational technology and generative AI tools.Utilizing recent advancements in machine learning and natural language processing to create, test, and deploy cutting-edge algorithmic tools that support empirical research.Leading and collaborating on projects that involve AI, machine learning, natural language processing, and extensive experimentation.Contributing to the design and implementation of randomized controlled trials and other empirical methodologies to assess the effectiveness of AI-driven interventions.Working closely with researchers to convert theoretical models into high-performance, production-ready systems.Co-authoring or contributing to academic papers and reports for peer-reviewed journals, conferences, and broader audiences.Keeping up with emerging technologies and research in AI, computational social science, and causal inference.Adhering to Harvard University’s IT technical standards and Code of Conduct.Projects you may be involved in include, but are not limited to:AI in Education: We are developing AI-powered technologies that exceed standard tools by providing customized support for student learning. Our flagship tool, PingPong, is currently being evaluated through a large-scale randomized experiment.

Your Role at Lila Sciences We are in search of a Senior Software Engineer to become a pivotal member of our Applied AI team, contributing to the development of our next-generation AI-powered scientific platform. This position involves designing and refining backend systems, data pipelines, and AI integrations that facilitate intelligent, data-centric applications. You will operate at the crossroads of backend engineering and machine learning, ensuring that our platform scales effectively and supports state-of-the-art applied AI methodologies such as Retrieval-Augmented Generation (RAG), agentic AI, and large language model (LLM) integration. This opportunity is perfect for individuals who excel at merging software engineering with applied AI, transforming research into production-level systems that foster genuine scientific breakthroughs. If you are driven by the challenge of building high-performing, sophisticated systems that maximize the utility and impact of AI, we would be eager to connect with you! Your Contributions Applied AI Integration: Design and implement backend services and data pipelines that underpin advanced AI applications, including LLMs, RAG, and agentic frameworks. API & Service Development: Create high-performance APIs and microservices that facilitate seamless interactions between AI models, scientific tools, and user-facing applications. Data Pipeline Architecture: Architect and oversee scalable pipelines adept at managing structured, unstructured, and vectorized data for AI/ML workloads. Database & Knowledge Systems: Develop and optimize SQL, NoSQL, and vector databases to ensure low-latency AI retrieval and inference tasks. Cloud & Infrastructure: Utilize AWS, Kubernetes, and infrastructure-as-code (Terraform/CloudFormation) to construct resilient, production-ready AI platforms. Performance & Reliability: Identify system bottlenecks, optimize for efficiency and speed, and guarantee the reliability and fault-tolerance of AI-driven processes. Collaboration: Work closely with ML researchers, platform engineers, and scientists to translate models and algorithms into scalable, production-ready solutions.

Amylyx Pharmaceuticals is on a bold mission to revolutionize the treatment of diseases with significant unmet needs. Where others perceive obstacles, we recognize opportunities that we pursue with a sense of urgency, scientific rigor, and steadfast dedication to the communities we serve. Our focus is currently on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).Our mission thrives on the commitment of our team. Our core values—be audacious, be curious, be authentic, be engaged, and be accountable—foster a culture of care. At Amylyx, we have assembled a highly skilled team eager to take decisive action because the communities we support cannot afford to wait. If you share our enthusiasm and are committed to addressing some of the most challenging problems in medicine, we invite you to explore the opportunity below and submit your application.The OpportunityThe Director of Clinical Sciences will play a pivotal role within the Clinical Development team, providing essential scientific guidance for ongoing projects. This position reports to a Medical Director and involves cross-functional collaboration with R&D, program management, clinical operations, biostatistics, and data management. The candidate will support and propel key developmental efforts for clinical studies and the execution of the overall Clinical Development Plans (CDP).

KAYAK, a proud member of Booking Holdings (NASDAQ: BKNG), stands as a premier travel search engine, processing billions of queries to assist customers in discovering their ideal flight, accommodation, rental car, and vacation package. Our innovative corporate travel solution, KAYAK for Business, is redefining business travel.Joining KAYAK means becoming part of a dynamic travel organization that encompasses a variety of global metasearch brands, including momondo, Cheapflights, and HotelsCombined. Our journey from a startup to an industry frontrunner is fueled by innovation, and every team member is empowered to leave their mark. Our mission is to develop the most effective travel search engine, simplifying global exploration for everyone.We are seeking talented Java Backend Engineers to enhance and sustain KAYAK’s search and booking systems. If you are passionate about travel and committed to crafting reliable and user-friendly experiences, we invite you to apply.This position requires in-office work at our Cambridge, MA location at least 3 days a week.

Pioneering Medicines, part of Flagship Pioneering, develops a broad range of new treatments by applying advanced scientific platforms. The team combines deep drug development knowledge with creative approaches to uncover and advance new therapeutic ideas. Close collaboration with Flagship’s bioplatform companies and external partners helps align efforts with R&D priorities, aiming to move discoveries quickly toward development. Role overview The Senior Director, Head of Toxicology leads the toxicology function at Pioneering Medicines. This position sets and executes nonclinical safety strategies across a varied and fast-moving portfolio. The role covers both investigative and regulatory toxicology, supporting multiple therapeutic modalities. Key responsibilities Establish and oversee nonclinical safety strategies for a growing portfolio of drug candidates. Provide scientific and strategic guidance for investigative and regulatory toxicology activities. Collaborate with multidisciplinary teams to support candidate selection and preclinical development. Ensure programs are prepared for regulatory submissions and early clinical development. Requirements Strong analytical skills and scientific rigor. Clear, effective communication across teams and partners. Experience influencing projects from discovery through early clinical stages. This role is based in Cambridge, MA.

POS-9034About Our TeamThe Commerce Hub at HubSpot is revolutionizing how businesses sell, bill, and manage revenue seamlessly within our platform. Handling billions in customer transactions, our focus on accuracy, clarity, and reliability is paramount. We are developing an AI-first commerce ecosystem that integrates flawlessly with HubSpot’s CRM, offering a streamlined, consistent, and adaptable experience for both sellers and buyers.About the RoleWe are in search of a Principal Software Engineer to drive the technical evolution of Commerce Hub. This pivotal role demands hands-on involvement, where you will engage in coding, exploring services, evaluating complex designs, troubleshooting intricate systems, and taking ownership of the architecture for critical components in CPQ, Billing, Payments, and Revenue OS.Your ResponsibilitiesDevelop a Cohesive, Scalable PlatformInfluence the technical roadmap for CPQ, Billing, and Payments using strong, decisive patterns.Define and enhance core domain models to ensure consistent and predictable behavior for pricing, products, contracts, invoices, and payments.Create frameworks that facilitate easy extensions without increasing complexity.Be a Proactive, Impactful BuilderRegularly write code, lead design reviews, and construct impactful systems from start to finish.Manage extensive multi-team projects that encompass CPQ, Billing, and Payments.Transform prototypes into scalable production-ready solutions.Guide Architectural DirectionEstablish patterns for extensibility, contract boundaries, financial accuracy, event-driven consistency, and safe interactions between AI/agents and commerce objects.Advocate for simplicity in complex domains while maintaining consistency across surfaces.Collaborate Closely with Product LeadershipShape product strategies across CPQ, Buyer Portal, and Revenue OS.Assist teams in navigating trade-offs between speed, accuracy, compliance, and long-term platform sustainability.Elevate Organizational StandardsMentor senior engineers and technical leads.Drive informed design choices and facilitate learning from incidents and significant migrations.Encourage teams to align on best practices and strategic goals.