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Principal Scientist in Biologics Cell Line Development

AsimovBoston, MA
On-site Full-time

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Experience Level

Senior

Qualifications

Candidates should possess an extensive background in CHO cell line development, with a focus on biologic therapeutics. A strong foundation in experimental design, team management, and cross-functional collaboration is essential. Ideal candidates will have a passion for innovation in the biotechnology landscape.

About the job

Asimov builds tools for designing living systems, combining mammalian synthetic biology with software to support next-generation therapeutics. The Biologics Cell Line Development team in Boston, MA, is growing, and we're seeking a Principal Scientist to help lead our efforts in CHO-based cell line development for biologic therapeutics moving into clinical trials.

Role Overview

This Principal Scientist position calls for a scientific leader ready to manage a team and drive innovation in cell line development. The role involves designing and executing complex experiments, improving expression systems, and collaborating closely with teams across synthetic biology, modeling, process development, and analytics. The work directly supports Asimov’s mission to advance biological engineering in a startup environment.

What You Will Do

  • Oversee CHO cell line development, including transfection, cloning, characterization, and cell banking using advanced technologies.
  • Develop new genetic components, engineer host cell lines, and refine development processes to improve biologics production.
  • Stay current with emerging practices in biologics cell line development and manufacturing, applying new strategies to ongoing projects.
  • Represent the cell line development group on cross-functional projects, making key decisions and communicating progress and plans.
  • Contribute to the scientific community by presenting at conferences, filing patents, and publishing peer-reviewed research.
  • Lead and mentor a team of at least three scientists, providing technical guidance and supporting their career growth.

Qualifications

  • At least 8 years of experience in CHO-based cell line development, with a focus on IgG and bispecific expression in an industrial setting.
  • Demonstrated success in creating innovative solutions and experimental approaches in cell line development.
  • Experience managing and developing scientific teams.
  • Strong communication skills for effective work across multidisciplinary groups.

About Asimov

Asimov is at the forefront of synthetic biology, dedicated to crafting innovative solutions that enhance our capability to design living systems. Our cutting-edge platform is set to transform the production of therapeutics, making a significant impact on healthcare and society.

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