Principal Scientist in Medicinal Chemistry

iambic therapeuticsSan Diego HQ

On-site Full-time

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Experience Level

Senior

Qualifications

Candidates must have the following qualifications:BS, MS, or PhD in chemistry, focusing on synthetic organic chemistry. Relevant experience in small molecule drug discovery: B. S. with 15+ years, M. S. with 12+ years, or Ph. D. with 8+ years of experience. Demonstrated success in moving drug discovery programs from lead candidates to advanced stages. In-depth experience in lead optimization for potency, selectivity, ADME, and PK parameters. Familiarity with modern synthetic organic chemistry techniques, supported by publications and patents. Hands-on experience with target protein degradation and modalities associated with it.

About the job

iambic therapeutics is seeking a Principal Scientist in Medicinal Chemistry to join the team onsite at our San Diego headquarters. This role calls for an accomplished medicinal chemist who brings a strong track record in drug discovery and thrives in a collaborative, multidisciplinary setting. The position involves close interaction with teams focused on automated experimentation, AI-driven molecular design, property prediction, and bioassay data generation.

What You Will Do

Design and refine strategies to identify and optimize lead molecules for potency, selectivity, and ADME properties, using multivariate SAR analysis and hypothesis-driven design.
Apply a broad range of modern organic chemistry transformations and synthetic methodologies, including parallel experimentation, to advance project goals.
Work closely with colleagues in molecular and cellular biology, pharmacology, computational chemistry, ADME, and related groups to drive discovery efforts.
Shape the use of computational approaches, automated synthesis, and high-throughput experimentation in medicinal chemistry projects.
Collaborate with AI and machine learning teams to build and apply predictive models for novel molecule design.
Clearly communicate project updates and findings to the broader team and stakeholders.
Contribute to the Chemistry research group, supporting a culture of scientific rigor, innovation, and teamwork.

Qualifications

BS, MS, or PhD in chemistry, with a focus on synthetic organic chemistry.
Direct experience in small molecule drug discovery within biotech or pharma: minimum 15+ years with a BS, 12+ years with an MS, or 8+ years with a PhD.
Documented success advancing drug discovery programs from lead identification through advanced candidate stages.
Deep experience optimizing lead compounds for potency, selectivity, ADME, and pharmacokinetics.
Expert knowledge of modern synthetic organic chemistry methods, supported by publications and patents.
Hands-on familiarity with target protein degradation and modalities such as molecular glues and PROTACs.

This position is based onsite at our San Diego HQ.

About iambic therapeutics

iambic therapeutics is at the forefront of drug discovery, harnessing cutting-edge technology and a collaborative spirit to tackle some of the most challenging problems in medicinal chemistry. Our San Diego headquarters serves as a hub for innovation, where cross-disciplinary teams work together to create transformative therapies.

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Principal Scientist in Medicinal Chemistry

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Role Overview iambic therapeutics is seeking a Principal Scientist in Medicinal Chemistry to join the team onsite at our San Diego headquarters. This role calls for an accomplished medicinal chemist who brings a strong track record in drug discovery and thrives in a collaborative, multidisciplinary setting. The position involves close interaction with teams focused on automated experimentation, AI-driven molecular design, property prediction, and bioassay data generation. What You Will Do Design and refine strategies to identify and optimize lead molecules for potency, selectivity, and ADME properties, using multivariate SAR analysis and hypothesis-driven design. Apply a broad range of modern organic chemistry transformations and synthetic methodologies, including parallel experimentation, to advance project goals. Work closely with colleagues in molecular and cellular biology, pharmacology, computational chemistry, ADME, and related groups to drive discovery efforts. Shape the use of computational approaches, automated synthesis, and high-throughput experimentation in medicinal chemistry projects. Collaborate with AI and machine learning teams to build and apply predictive models for novel molecule design. Clearly communicate project updates and findings to the broader team and stakeholders. Contribute to the Chemistry research group, supporting a culture of scientific rigor, innovation, and teamwork. Qualifications BS, MS, or PhD in chemistry, with a focus on synthetic organic chemistry. Direct experience in small molecule drug discovery within biotech or pharma: minimum 15+ years with a BS, 12+ years with an MS, or 8+ years with a PhD. Documented success advancing drug discovery programs from lead identification through advanced candidate stages. Deep experience optimizing lead compounds for potency, selectivity, ADME, and pharmacokinetics. Expert knowledge of modern synthetic organic chemistry methods, supported by publications and patents. Hands-on familiarity with target protein degradation and modalities such as molecular glues and PROTACs. This position is based onsite at our San Diego HQ.

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