Principal Scientist in Process Chemistry

Role Overview Oric Pharmaceuticals is seeking an Associate Director of Process Chemistry based in South San Francisco. This position shapes the direction of drug development by designing and refining synthetic routes for new therapeutic candidates. The work emphasizes both operational efficiency and scalability. What You Will Do Lead a team of chemists focus…

Zipline runs a large autonomous logistics network, delivering medicine, food, and essential goods across four continents. The company’s technology strengthens supply chains and reduces congestion, completing a delivery every 30 seconds and logging over 140 million commercial autonomous miles. Customers include healthcare providers, governments, retailers, and global organizations that depend on Zipline for critical deliveries and expanded economic access. This South San Francisco-based position centers on supporting operations using data and process insights. The Site Operations Process Associate helps build and maintain dashboards, monitors performance metrics, and escalates operational concerns to the right teams. Relocation support is available for those moving to the area. Key responsibilities Develop and maintain dashboards to track operational metrics and performance. Ensure dashboards remain accurate, user-friendly, and relevant to team needs. Refine reporting processes by improving metrics and enhancing data visibility. Who succeeds in this role This position fits someone who is analytical, detail-oriented, and enjoys using data to improve processes and keep stakeholders informed.

About UsDeep Apple Therapeutics, a dynamic biotechnology firm within the Apple Tree Partners (ATP) portfolio, is located in the heart of the Bay Area. Our mission is to revolutionize drug discovery by leveraging advanced molecular docking and structural biology techniques. By utilizing cutting-edge computer-aided drug design technologies and a state-of-the-art research platform, we are committed to accelerating the development of innovative therapeutic solutions.Role OverviewWe are in search of a seasoned and innovative leader to take on the role of Head of Computational Chemistry. This pivotal position involves directing our computational initiatives for virtual hit discovery. Reporting directly to the Head of Drug Discovery, you will lead a talented team of computational chemists, data scientists, and machine learning engineers, enhancing our drug discovery pipeline through the integration of advanced deep learning models. Your leadership will be critical in refining our virtual screening capabilities, optimizing molecular design, and fostering cross-functional collaborations to transform computational insights into effective therapeutic leads. We seek a candidate with a minimum of 10 years of experience in computational modeling, particularly in applying deep learning techniques to drug discovery.Key ResponsibilitiesGuide and mentor a diverse team in creating and optimizing computational chemistry workflows for virtual hit discovery, including both ligand-based and structure-based modeling.Develop and implement deep learning models (including generative AI for molecule design) to accurately predict molecular properties, binding affinities, and ADMET profiles.Oversee the integration of high-throughput virtual screening platforms, utilizing extensive datasets and cloud computing resources (AWS and Google Cloud).Work collaboratively with biology, medicinal chemistry, and machine learning teams to validate computational predictions through iterative feedback loops.Lead strategic initiatives, forming partnerships with academic institutions, technology companies, and CROs to bolster our AI-driven discovery capabilities.Stay informed about emerging technologies in computational chemistry and deep learning, incorporating these advancements into our workflow to maintain a competitive advantage.Manage project timelines, budgets, and resources, ensuring compliance with data integrity and intellectual property standards.

Join AbbVie as an Associate Director of Innovation, where you will play a crucial role in driving the future of our research and development initiatives. This dynamic position allows you to collaborate with cross-functional teams to identify and implement innovative solutions that enhance our product offerings.

About Us Kardigan is a pioneering heart health company dedicated to transforming cardiovascular disease into a preventable, treatable condition, aiming to eliminate it as the leading cause of death globally.Our mission is to develop a diverse range of targeted treatments concurrently that will lead to the cures our patients with cardiovascular diseases deserve. Founded by industry leaders Tassos Giannakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s founders have reunited following their success at MyoKardia, where they facilitated the discovery and development of mavacamten, the first cardiac myosin inhibitor, culminating in the acquisition by Bristol Myers Squibb in 2020. We boast a cutting-edge discovery and translational research platform, a pipeline full of late-stage candidates, and an exceptional team devoted to enhancing patient lives. At Kardigan, our values drive our work, interactions, and achievements. We are patient-centered, fiercely committed to improving lives and prioritizing patient needs. We believe in authenticity, fostering an environment of acceptance through honest leadership. With a curiosity-driven mindset, we encourage innovative thinking and adaptability. We strive for team success, supporting one another in our collective mission with urgency and excellence. Finally, we aim to enable the impossible, taking calculated risks to inspire innovation and advance scientific breakthroughs. Our core values empower us daily to make a significant impact. Position Title: Associate Director (AD), BiostatisticsDepartment: Development - Data ScienceReports To: Director, BiostatisticsLocation: South San Francisco, CA or Princeton, NJ

At Alumis Inc., we are passionate about revolutionizing the treatment landscape for individuals suffering from autoimmune diseases. Our commitment to precision medicine drives us to innovate treatments that significantly enhance patient outcomes, addressing the unmet needs of those living with immunologic conditions.We are currently in search of an experienced Associate Director of Biostatistics to lend their statistical acumen and operational support to both early-stage and late-stage clinical programs. This pivotal role will see you acting as the lead statistician for various studies, collaborating with multidisciplinary teams to facilitate clinical development and informed decision-making through data analysis. You will play an active role in critical deliverables, oversee CRO activities, and mentor junior team members, fostering a culture of excellence within our statistical team.

Calico Labs is hiring an Associate Director of External Communications based in South San Francisco, CA. This leadership role focuses on shaping and executing external communication strategies to strengthen the company’s public profile. Role overview The Associate Director will oversee how Calico Labs communicates its mission, research, and advancements to the public. The position involves working closely with teams across the organization to craft clear, compelling narratives that highlight the company’s work in biotechnology. What you will do Lead the development and execution of external communication strategies Enhance brand visibility through effective storytelling and media outreach Manage media relations to ensure accurate and broad coverage of company initiatives Collaborate with cross-functional teams to align messaging Build partnerships and engage with key stakeholders Requirements Proven experience in public relations and strategic communication Strong background in managing media relations Ability to develop and deliver clear, engaging narratives Experience collaborating with multiple teams This position offers the chance to play a central role in how Calico Labs shares its vision and progress with the world.

Join AbbVie as an Associate Director of AI Transformation, where you will play a pivotal role in driving our AI initiatives to enhance patient outcomes and operational efficiency. This leadership position requires a blend of strategic vision and technical expertise, ensuring our AI solutions align with our organizational goals.In this role, you will lead a cross-functional team, collaborate with stakeholders, and leverage cutting-edge AI technologies. Your contributions will directly impact our commitment to innovation and excellence in healthcare.

Location: South San Francisco, CA, United StatesJob Identification: 2223Job Schedule: Full timeResponsibilitiesAssist in conducting research experiments under the guidance of a Scientist.Perform laboratory experiments to support the development and optimization of products, services, and technologies, from feasibility studies to application testing and stability assessments.Develop methodologies and prepare Standard Operating Procedures (SOPs) as necessary.Acquire chemicals, materials, and reagents for experiments.Handle and prepare chemicals and biochemical reagents for experimental procedures.Ensure proper disposal of chemical and biological waste, maintaining accurate records as required.Calibrate and maintain scientific instruments and laboratory equipment.Keep organized, detailed, and precise records of all experimental processes and data.Conduct data analysis using tools such as Excel, Tableau, flow cytometry, and image analysis.Deliver project status updates and reports.Review relevant literature and apply advanced knowledge to enhance research outcomes.QualificationsBachelor's degree or higher in Biology, Chemistry, or a related scientific field, with 0-10 years of experience in a research setting (preferably at least 3 years).Experience in conducting experiments involving Next Generation Sequencing (NGS), RT-qPCR, fluorescence spectroscopy, biomolecule conjugation, immunoassays, data analysis, and image analysis.Proven ability to effectively plan, execute, analyze, and document research experiments.Skilled in the operation and maintenance of instruments for chemical and spectroscopic analysis, including fluorescence spectroscopy, flow cytometry, and UV-VIS.Highly organized, adaptable, and capable of multitasking in a fast-paced environment with strict timelines.Excellent attention to detail in making experimental observations.Proficient pipetting skills are required.Familiarity with liquid handling systems is preferred, but not mandatory.Strong verbal and written communication skills are essential, as the role requires frequent updates, reports, technical meetings, and presentations.#LI-LP1About UsMyriad Genetics Inc. is a pioneering company in personalized medicine, committed to transforming patient lives globally through innovative molecular diagnostics. We discover and commercialize tests that assess disease risk, diagnose conditions, evaluate disease progression, and inform treatment decisions across six key medical specialties. Our strategic focus is on maintaining leadership in molecular diagnostics while improving patient care and reducing healthcare costs.

Role overview Calico Labs is hiring a Director or Associate Director of Toxicology to lead research into the safety profiles of compounds under development. This leadership role shapes the approach to evaluating toxicological effects and plays a key part in decisions that guide the direction of health research at Calico Labs. Key responsibilities Direct research initiatives to assess the toxicological impacts of compounds in the development pipeline Guide safety and efficacy evaluations at each stage of the development process Work closely with scientific teams to inform study design and interpret results Apply toxicology expertise to advance Calico Labs' mission in health innovation Location This position is based in South San Francisco, CA.

Join AbbVie as an Associate Director in our R&D Information Research IT team, where you will play a pivotal role in driving innovation and supporting our research initiatives. In this hybrid position, you will collaborate with cross-functional teams to enhance our information systems and contribute to the advancement of groundbreaking therapies.

Calico Labs seeks an Associate Director or Director of In Vivo Physiology to join its team in South San Francisco, CA. This leadership role centers on research aimed at understanding and addressing diseases linked to aging. Role overview The Associate Director or Director will shape the scientific direction for in vivo physiology studies. This position supports Calico’s mission to advance health through research focused on age-related conditions. Key responsibilities Guide research projects that investigate the biology of aging and related diseases Direct scientific strategy and help set priorities for the in vivo physiology group Support Calico’s broader goals by fostering collaboration and scientific excellence Location This position is based in South San Francisco, CA.

The OpportunityAt the forefront of transforming drug discovery, insitro leverages the powerful intersection of multi-modal data and AI to redefine the development of medicines for complex diseases. Our mission is propelled by our capacity to attract, nurture, inspire, and retain a diverse array of exceptional talent, all while fostering a collaborative, high-performing, inclusive, and equitable culture.We are seeking an (Associate) Director, People Partner who will play a pivotal role in actualizing our people vision and strategy, setting a new benchmark for employee experience within the industry. In this influential position, you will provide coaching and support to leaders, managers, and team members across various situations, including employee relations, organizational design, and talent development.This role reports directly to the Chief People Officer and serves as a vital member of the leadership team. The position is based in South San Francisco, requiring onsite presence most days, with the flexibility to work remotely up to two days a week.ResponsibilitiesStrategic Partnership & Organizational EffectivenessAdvise executives on aligning manager and employee capabilities with mid-to-long-term business objectives.Collaborate with leaders across the organization to translate business strategies into people-centric initiatives that drive progress.Assist senior management in developing sustainable people and organizational strategies, programs, and practices that reflect our mission and goals.Identify and analyze root causes of workplace issues, team dynamics, and organizational inefficiencies.Talent Development & CoachingProvide coaching and guidance to leaders to enhance their managerial effectiveness in leadership team dynamics, organizational planning, change management, and talent management.Act as a trusted partner to managers and team members, proactively addressing obstacles that hinder optimal performance.Introduce best practices and innovative solutions for talent management, organizational design, retention, and engagement.People Operations & ComplianceCollaborate closely with the Legal team on employee relations matters.

Join AbbVie as a Scientific Director / Medical Director in the field of Medical Affairs focusing on Oncology, specifically targeting Ovarian Solid Tumor. In this pivotal role, you will lead strategic initiatives and research efforts aimed at improving patient outcomes through innovative therapies. Collaborate with cross-functional teams to develop and implement comprehensive medical strategies that align with our commitment to advancing oncology care.

Position SummaryCellares is on the lookout for a dynamic and driven Senior Scientist with a strong background in cell therapy manufacturing to become a vital member of our Process Development team. This role offers a unique opportunity to collaborate with various departments and make substantial contributions to the advancement of our innovative cell therapy manufacturing platform.In this pivotal position, you will be responsible for designing, coordinating, executing, and analyzing experiments related to cell therapy process development. Your efforts will be instrumental in enhancing and optimizing the Cellares platform. The ideal candidate will exhibit exceptional organizational skills, demonstrate technical leadership, and possess a proven track record in developing robust autologous and allogeneic cell therapy processes.We seek individuals who thrive in a fast-paced, mission-driven environment and are eager to embrace a diverse range of challenges as Cellares continues to expand.

The PositionAs the Director of Biostatistics at Maze Therapeutics, you will be pivotal in guiding the clinical advancement of our innovative therapeutic programs. This role involves close collaboration with teams in Clinical Science, Regulatory Affairs, Clinical Pharmacology, Development Science, and Translational Science, ensuring our clinical studies are methodologically sound, data-driven, and impactful.You will be responsible for the biostatistical strategy and execution, overseeing the entire process from study design to regulatory submissions, seamlessly blending hands-on expertise with strategic oversight. Your role will include representing the Biostatistics function in clinical study teams, guiding the interpretation of intricate data, and managing CRO partnerships to guarantee the delivery of high-quality statistical outputs.This position reports directly to the Vice President of Biometrics.Your ImpactLead biostatistical efforts for clinical studies, offering expert insights on study design, endpoints, and statistical methodologies.Oversee the completion of all technical and operational statistical tasks for a portfolio of clinical trials, ensuring the development and review of complex and innovative statistical analysis plans (SAPs).Work collaboratively with cross-functional teams on protocol development, study design discussions, and data interpretation.Partner with Statistical Programming to develop and validate analyses for internal purposes, publications, and regulatory submissions.Supervise CRO execution of statistical tasks, ensuring adherence to timelines, quality standards, and analytical approaches.Represent the Biostatistics department in regulatory interactions (FDA, EMA, PMDA, etc.), contributing to briefing documents, meeting preparations, and responses to agency inquiries.Contribute to clinical study reports (CSRs), integrated summaries (ISS/ISE), and regulatory submissions (NDA/BLA/MAA).Utilize advanced statistical techniques to analyze and interpret clinical, safety, biomarker, and exploratory data.Advise internal and external stakeholders on statistical methodologies, data integrity, model selection, and result interpretation.Lead the integration and analysis of diverse data sources to facilitate the delivery of special projects and statistical analysis plans for assigned products.Review and assess safety reports, biomarker analyses, and other elements of clinical trial monitoring.Enhance statistical software as needed by programming new techniques; stay updated on current and emerging trends in statistical analysis methodologies and tools.Provide biostatistical input into clinical development documentation and scientific publications.

About the RoleAs the Director of Statistics at AbbVie, you will lead a talented team of statisticians in designing and analyzing clinical trials, ensuring the highest standards of statistical rigor. You will collaborate with cross-functional teams to drive innovative solutions that impact patient outcomes.Key ResponsibilitiesOversee statistical methodology development and implementation for clinical research.Guide statistical analysis plans and ensure compliance with regulatory standards.Mentor and develop junior statisticians and promote a collaborative environment.

Join AbbVie as the Director of AI Transformation, where you will lead the charge in harnessing artificial intelligence to drive innovation and improve patient outcomes. You will be responsible for developing and implementing cutting-edge AI strategies that align with our mission to enhance the quality of life for patients around the globe. Collaborate with cross-functional teams to integrate AI technologies into our existing processes and workflows, ensuring that we stay at the forefront of healthcare advancements.

Cellares is on the lookout for a visionary and dynamic Director of Facilities Engineering to play a pivotal role in driving our mission to enhance access to transformative cell therapies.In this critical position, you will oversee the management, operations, and maintenance of our facilities and crucial support systems, ensuring adherence to GMP, quality, and Environmental Health and Safety (EHS) standards. Your responsibilities will include managing office spaces, cGMP cleanroom suites, QC laboratories, warehouses, utility systems (gases, HVAC, lab equipment), and all equipment integral to our cell therapy operations. Additionally, you will lead our maintenance and calibration programs, cleaning initiatives, and capital expansion projects (CAPEX), which involve facility buildouts.The ideal candidate will have a robust background in facilities leadership, particularly within cGMP operations in the biotech or pharmaceutical sectors. You will be instrumental in providing strategic vision and leadership to ensure the reliability of our facilities, compliance with state and federal regulations, and the continuous improvement of processes that propel our business growth.This position is multidisciplinary, requiring collaboration across various departments, including scientists, researchers, and engineers, to devise optimal solutions. We are looking for a proactive and self-sufficient individual who thrives in a fast-paced, mission-driven environment and is ready to embrace a diverse range of challenges as our company expands.