About the job
About Arc Institute
The Arc Institute is an innovative scientific organization dedicated to curiosity-driven fundamental research and technology development aimed at understanding and treating complex human diseases. Based in Palo Alto, California, we partner with prestigious institutions such as Stanford University, UCSF, and UC Berkeley to push the boundaries of scientific exploration.
At Arc, we believe in pioneering new institutional models that foster transformative research. We fully fund our Core Investigators’ research teams, freeing them from the constraints of traditional project-based grants. Our Technology Centers are at the forefront of biomedical research, enhancing experimental and computational technologies in collaboration with our scientists. We strive to provide unparalleled operational, financial, and scientific support, enabling our researchers to tackle long-term, high-risk endeavors that could lead to breakthroughs in areas like neurodegeneration, cancer, and immune dysfunction.
As an organization, we prioritize a culture of scientific inquiry, integrity, ambition, and collaborative spirit, understanding that a positive environment is crucial for sustained scientific excellence.
With nearly 300 employees and over $650 million in committed funding, Arc is expanding rapidly, equipped with a state-of-the-art laboratory facility in Palo Alto.
About the Position
We are on the lookout for a dynamic Scientist specializing in cellular engineering and stem cell biology to join our Molecular Engineering team within the Genome Engineering Technology Center. This role involves designing, generating, and characterizing engineered human pluripotent stem cell (hPSC) lines for genetic perturbation screens in complex organoid models, aimed at exploring the genetic underpinnings of neurodegenerative disorders. Key projects include creating optimized effector systems for robust gene knockdown and activation throughout differentiation, introducing rare coding variants to model disease-associated mutations, and implementing cutting-edge genome engineering technologies to enhance perturbation capabilities. Your contributions will be vital to the Institute's Alzheimer’s Disease Initiative, a comprehensive effort to advance our understanding of this critical area.
