About the job
Revolution Medicines develops targeted therapies for patients with RAS-addicted cancers. The company’s pipeline includes several RAS(ON) inhibitors currently in clinical development, such as Daraxonrasib (RMC-6236), Elironrasib (RMC-6291), Zoldonrasib (RMC-9805), and RMC-5127. The team is dedicated to advancing treatments for cancers driven by mutations in the RAS signaling pathway.
Role overview
The Senior Safety Scientist will join the Global Patient Safety Science group, supporting pharmacovigilance and safety science activities across both early and late-stage clinical programs. This position covers the full portfolio of Revolution Medicines’ investigational therapies.
Key responsibilities
- Oversee safety for clinical studies, including reviewing and authoring protocols, Investigator's Brochures (IBs), Informed Consent Forms (ICFs), and Development Safety Update Reports (DSURs).
- Conduct medical review of individual case safety reports (ICSRs) and monitor safety surveillance for assigned products.
- Proactively perform medical safety surveillance during clinical trials to identify and address safety issues.
- Prepare and present safety data summaries to internal and external stakeholders.
- Engage in risk management activities, including routine safety data analysis, medical review of ICSRs, and literature review.
- Share knowledge on drug class safety issues and competitor landscape.
- Identify potential clinical safety concerns and recommend risk mitigation strategies.
- Contribute to preparation and maintenance of clinical trial protocols, IBs (including reference safety information), ICFs, DSURs, Risk Management Plans (RMPs), Core Content Development Summaries (CCDS), and product labeling.
- Review clinical protocols, IBs, ICFs, and related documents to ensure alignment with safety strategies.
Location
This role is based in Redwood City, California, United States.
