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Senior Scientist in Drug Product Development at Alumis | South San Francisco

Alumis Inc.South San Francisco
On-site Full-time $139K/yr - $169K/yr

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Experience Level

Senior

Qualifications

Key Responsibilities:Lead hands-on pre-clinical formulation development by identifying vehicles, excipients, and innovative technologies for poorly water-soluble compounds, supporting preclinical pharmacokinetics, efficacy, and toxicity studies. Execute and oversee pre-formulation activities, including the characterization of physicochemical and solid-state properties for investigational small molecules, utilizing instrumental analysis methods (HPLC/UPLC, DSC, XRPD) and method development. Collaborate effectively with external Contract Development and Manufacturing Organizations (CDMOs) to create early-stage drug products and oversee the production of clinical trial materials to meet clinical timelines. Demonstrate extensive experience in formulation development and process optimization for small molecule solid oral dosage forms, including modified-release products, by managing formulation and manufacturing process development activities. Exhibit excellent oral and written communication skills and adapt to a fast-paced team environment by delivering clear and concise updates. Assist in preparing relevant Chemistry, Manufacturing, and Controls (CMC) sections for key regulatory filings, including Investigational New Drug (IND) and New Drug Application (NDA), with experience in authoring technical reports and regulatory documents being an asset. Thrive in a dynamic small company atmosphere, proactively identifying project risks and preparing mitigation and contingency plans. Willingness to travel as necessary to support ongoing development activities. Educational Requirements:A Ph. D. in Pharmaceutical Sciences, Chemistry, Engineering, or a related field with a minimum of 8 years of relevant experience, or a B. S. or M. S. with 10+ years of related industrial experience.

About the job

At Alumis Inc., we are dedicated to revolutionizing the treatment landscape for patients suffering from autoimmune diseases. Our mission is to make a significant impact on the lives of those who have not benefited from recent medical advancements. We invite you to join us on this crucial journey.

We are in search of a highly skilled and driven Senior Scientist to join our Drug Product Development team. This role will thrive in a collaborative and dynamic setting, focusing on critical activities in the development of our innovative molecules. Your key responsibilities will include creating pre-formulation packages, selecting formulations, and developing manufacturing processes. Initially, this role will prioritize solid oral dosage form development, with potential for involvement in other dosage forms as we expand.

About Alumis Inc.

Alumis Inc. is at the forefront of precision medicine, committed to transforming the lives of patients with autoimmune diseases through innovative treatments. Our goal is to redefine outcomes for patients who have long faced challenges in managing their conditions.

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