About the job
At Olema Oncology, we are unwavering in our commitment to advancing innovative treatments for breast cancer and beyond. Our flagship candidate, palazestrant (OP-1250), is a groundbreaking complete estrogen receptor antagonist (CERAN) currently being developed for metastatic breast cancer. With the potential to be a market leader, it is designed for use both as a monotherapy and in combination therapies for ER+/HER2- metastatic breast cancer. Additionally, our next candidate, OP-3136, is a powerful KAT6 inhibitor that aims to set a new standard in the field.
Our success is fueled by the collaborative spirit that drives our team to support, inspire, and challenge each other. At Olema, we prioritize our people, ensuring that our endeavors yield unparalleled results. If you are eager to be part of a transformative journey, join us as we strive to make a significant difference for our patients, your career, and the future of medicine.
You can view our latest corporate deck and other presentations here.
About the Role: Senior Scientist, Medicinal Chemistry
As the Senior Scientist in Medicinal Chemistry, you will report directly to the Associate Director of Medicinal Chemistry and play a pivotal role in designing and synthesizing novel small molecules to support our hit-to-lead and lead optimization initiatives. You will collaborate closely with our internal medicinal chemistry team and oversee external resources involved in the development of new small molecule drug candidates. You may also lead the organic chemistry efforts within multidisciplinary project teams, advancing drug discovery projects from inception to clinical trials to fulfill our mission of delivering innovative medicines to cancer patients.
This position is based in our San Francisco Bay Area Laboratory and requires approximately 5% travel.
Your core responsibilities will include:
- Executing hit-to-lead and lead optimization by designing and synthesizing novel small molecules.
- Guiding external chemistry resources through the design of synthetic strategies, target prioritization, and innovative solutions to complex chemistry challenges.
- Advancing novel small molecule hits and lead compounds into clinical candidates by utilizing structure-based drug design and multi-parameter lead optimization.
